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On the myth of antibrain antibodies in schizophrenia — a critical overview

  • K. Schott
  • A. Batra
  • E. Richartz
  • R. Sarkar
  • M. Bartels
  • G. Buchkremer
Conference paper
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Antibrain antibodies are regarded as a hallmark of an autoimmune process in schizophrenia. The literature, however, is contradictory to a large extent. Furthermore, the older studies used now outdated methodology. The modern studies using Western and Immunoblot technique were greatly negative. Our own results on the occurrence of antibrain antibodies in schizophrenia were disappointing over the last years. In the present study we investigated antibody binding in serum from schizophrenic patients to the nuclear, membrane and water soluble protein fractions from human brain by Western and Immunoblot. There were no specific results. Therefore, we conclude that there is at present no proof of antibrain antibodies in schizophrenia.

Keywords

Schizophrenic Patient Water Soluble Protein Paranoid Schizophrenia Critical Overview BioI Psychiatry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Batra A, Wegerer C, Bartels M, Günthner A, Mann K, Schott K (1995) Antibody reactivity in serum against neuropeptides in mental disorder. A dot — ELISA analysis. Neurol Psychiatry Brain Res 3: 91–94Google Scholar
  2. DeLisi LE, Weber RJ, Pert CB (1985) Are their antibodies against brain in sera from schizophrenic patients? Review and prospectus. Biol Psychiatry 20: 110–115CrossRefGoogle Scholar
  3. Ehrnst A, Wiesel FA, Bjerkenstedt FB, Tribukait B, Jonsson J (1982) Failure to detect immunological stigmata in schizophrenia. Neuropsychobiol 8: 169–171CrossRefGoogle Scholar
  4. Heath RG, Krupp IM, Byers LW, Lijekvist JI (1967a) Schizophrenia as an immunological disorder. II. Effects of serum protein fractions on brain function. Arch Gen Psychiatry 16: 10–23PubMedCrossRefGoogle Scholar
  5. Heath RG, Krupp IM, Byers LW, Lijekvist JI (1967b) Schizophrenia as an immunological disorder. III. Effects of antimonkey and antihuman brain antibody on brain function. Arch Gen Psychiatry 16: 24–33PubMedCrossRefGoogle Scholar
  6. Henneberg AE, Hotter S, Ruffert S (1994) Increased prevalence of antibrain antibodies in the sera from schizophrenic patients. Schizophr Res 14: 15–22PubMedCrossRefGoogle Scholar
  7. Jankovic BD, Djodjijevic D (1991) Differential appearance of autoantibodies to human brain S 100 protein, neuron specific enolase, and myelin basic protein in psychiatric patients. Int J Neur Sci 60: 119–127CrossRefGoogle Scholar
  8. Keller A, Schott K, Batra A, Bartels M, Buchkremer G (1995) Brain antibodies in mental disorders. Neurol Psychiatry Brain Res 3: 225–228Google Scholar
  9. Knight JG, Knight A, Menkes DB, Muller PE (1990) Antibodies against brain septal region antigens specific to unmedicated schizophrenia? Biol Psychiatry 28: 467–474PubMedCrossRefGoogle Scholar
  10. Lehmann-Facius H (1937) Über die Liquordiagnose der Schizophrenien. Klin Wochenschr 16: 1646–1648CrossRefGoogle Scholar
  11. Lehmann-Facius H (1939) Serologisch — analytische Versuche mit Liquoren und Seren von schizophrenen bzw. atypischen Psychosen. Allg 2 Psychiatr Grenzgeb 110: 232–243Google Scholar
  12. Neuhoff V, Stamm R, Eible H (1985) Clear background and highly sensitive protein staining with Coomassie blue dyes in polyacrylamide gels: a systematic analysis. Electrophoresis 6: 427–448CrossRefGoogle Scholar
  13. Plioplys AV, Thibault S, Bouchard JP, Cockburn C, Hawkes R (1987) Anti-CNS antibodies in neurological and psychiatric disorders. J Neurol Neurosurg Psychiatr 50: 1514–1521PubMedCrossRefGoogle Scholar
  14. Poehling HM, Neuhoff V (1980) One — and two — dimensional electrophoresis in microslab gels. Electrophoresis 1: 90–102CrossRefGoogle Scholar
  15. Schott K, Batra A (1995) No antibody binding to serotonin in serum of patients with paranoid schizophrenia and major depressive disorder. Eur Psychiatry 10: 372PubMedCrossRefGoogle Scholar
  16. Schott K, Jenner A, Wiethölter H, Schabet M, Stevens A (1988) Demyelination of sciatic nerve in acute experimental allergic neuritis of the rat. J Neuroimmunol 20: 53–61PubMedCrossRefGoogle Scholar
  17. Schott K, Batra A, Richartz E, Sarkar R, Bartels M, Buchkremer G (1997) Serumantibodies to brain lipids in mental disorder. Neurol Psychiatry Brain Res 5: 31–34Google Scholar
  18. Schott K, Batra A, Richartz E, Sarkar R, Günthner A, Bartels M, Buchkremer G (1998) Antibrain antibodies in mental disorder: no evidence for antibodies against synaptic membranes. Neural Transm 105: 517–524CrossRefGoogle Scholar
  19. Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria. Arch Gen Psychiatry 35: 773–782PubMedCrossRefGoogle Scholar
  20. Sundin U, Thelander S (1989) Antibody reactivity to brain membrane proteins in serum from psychiatric patients. Brain Behav Immun 3: 345–358PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • K. Schott
    • 1
  • A. Batra
    • 1
  • E. Richartz
    • 1
  • R. Sarkar
    • 1
  • M. Bartels
    • 1
  • G. Buchkremer
    • 1
  1. 1.Universitätsklinik für Psychiatrie und PsychotherapieTübingenFederal Republic of Germany

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