On the myth of antibrain antibodies in schizophrenia — a critical overview
Antibrain antibodies are regarded as a hallmark of an autoimmune process in schizophrenia. The literature, however, is contradictory to a large extent. Furthermore, the older studies used now outdated methodology. The modern studies using Western and Immunoblot technique were greatly negative. Our own results on the occurrence of antibrain antibodies in schizophrenia were disappointing over the last years. In the present study we investigated antibody binding in serum from schizophrenic patients to the nuclear, membrane and water soluble protein fractions from human brain by Western and Immunoblot. There were no specific results. Therefore, we conclude that there is at present no proof of antibrain antibodies in schizophrenia.
KeywordsSchizophrenic Patient Water Soluble Protein Paranoid Schizophrenia Critical Overview BioI Psychiatry
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