Interaction of the serotonergic and the immune systems: 5HT-Moduline
The serotonergic system is known as a neuromodulatory system present in the brain and participating to the homeostasis of the brain. Its major morphological and anatomical features are favoring this role. Accordingly it is involved in many physiological functions and a number of psychiatric dysfunctions. Amongst the numerous receptors involved in its functions, 5HT1B receptors constitute a particular subtype located on neuron terminals and regulating the release of the corresponding neurotransmitter. These receptors are specifically the target of an endogenous tetrapeptide (5HT-Moduline) characterized in mammalian brain and regulating the functional activity of the receptor as an allosteric modulator.
Immunocompetent cells were shown to also contain 5HT1B receptors using molecular biology, immunocytochemistry and pharmacology. These receptors participate to the control of transcriptional activity of immediate early genes, and stimulate the proliferation of cells. 5HT-Moduline also interacts with the function of 5HT1B receptor at this level, playing an antagonistic role. The observed results indicate that the serotonergic system not only exerts a neuromodulatory role in central nervous tissue but presumably also controls the activity of immunocompetent cells. The serotonergic system may be involved in the reciprocal neuroimmune relationships via mechanisms which implicate 5HT1B receptors and their allosteric modulator 5HT-Moduline.
KeywordsSerotonergic System 5HT1B Receptor Immunocompetent Cell Allosteric Modulator Immediate Early Gene
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