Borna disease virus in patients with psychiatric disorders or fibromyalgia — demonstration of antibodies is highly dependent on the detection method

  • A. Batra
  • A. Batra
  • K. Schott
  • L. Stitz
Conference paper
Part of the Key Topics in Brain Research book series (KEYTOPICS)


In the past a possible association between Borna disease vims (BDV)-infection and psychiatric disorders in man was proposed. We investigated sera from patients with schizophrenia, major depression and fibromyalgia for the presence of BDV-specific antibodies and examined the sensitivity of different detection methods for virus specific antibodies. Performing Western blot analysis, immunofluorescence assay and virus neutralisation assay we received inconsistent results. We found a high prevalence (10%) of BDV-specific antibodies in the sera of schizophrenic patients using Western blot, but could not confirme these data by immunofluorescence or virus neutralisation assay. These inconsistent results indicate the need for a critical review of all reported results of significantly enhanced seroprevalence of BDV antibodies in neuropsychiatric patients.


Chronic Fatigue Syndrome Psychiatric Patient Lymphocytic Choriomeningitis CRL1405 Cell Neuropsychiatric Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • A. Batra
    • 2
  • A. Batra
    • 1
  • K. Schott
    • 1
  • L. Stitz
    • 2
  1. 1.Department of Psychiatry and PsychotherapyUniversity of TübingenTübingenGermany
  2. 2.Federal Research Center for Virus Diseases of AnimalsTübingenFederal Republic of Germany

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