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T cell subsets and expression of integrins in peripheral blood of patients with migraine and chronic tension type headache

  • M. Empl
  • P. Sostak
  • M. Breckner
  • M. Riedel
  • N. Müller
  • R. Gruber
  • S. Förderreuther
  • A. Straube
Conference paper
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Neurogenic inflammation of durai vessels has been hypothesised to be an essential part of migraine physiopathology. Analysis of lymphocyte subpopulations and integrin expression in the peripheral blood of headache patients (migraine and chronic tension type headache) showed an elevated proportion of T-helper cells and T-helper memory cells as well as a higher expression of LFA-1 on T-helper and T-suppressor cells. This could be a sign of enhanced endothelium and lymphocyte interaction as it would be expected in an inflammatory process of cranial vessels.

Keywords

Neurogenic Inflammation Chronic Tension Type Headache Plasma Protein Extravasation Cranial Vessel Lymphocyte Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Buzzi MG, Sakas DE, Moskowitz MA (1989) Indomethacin and acetylic acid block plasma protein extravasation in rat dura mater following electrical stimulation of the rat trigeminal ganglia. Eur J Pharmacol 165: 151–258CrossRefGoogle Scholar
  2. Buzzi MG, Dimitriadou V, Theoharides TC, Moskowitz MA (1992) 5-Hydroxytryptamine receptor agonist for the abortive treatment of vascular headaches block mast cell, endothelial and platelet activation within the rat dura mater after trigeminal stimulation. Brain Res 583: 137–149PubMedCrossRefGoogle Scholar
  3. Dimitriadou V, Buzzi MG, Theoharides TC, Moskowitz MA (199D) Ultrastructural evidence for neurogenically mediated changes in blood vessels of the rat dura mater and tongue following antidromic trigeminal stimulation. Neuroscience 44: 97–112Google Scholar
  4. Goadsby PJ, Edvinsson L (1993) The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 33: 48–56PubMedCrossRefGoogle Scholar
  5. Goadsby PJ, Edvinsson L, Ekman R (1990) Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 29: 183–187CrossRefGoogle Scholar
  6. Laffón A, García-Vicuña R, Humbría A, Postigo AA, Corbí AL, de Landázuri MO, Sánchez-Madrid F (1991) Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis. J Clin Invest 88: 546–552PubMedCrossRefGoogle Scholar
  7. Lub M, van Kooyk Y, Figdor CG (1995) Ins and outs of LFA-1. Immunol Today 16: 479–483PubMedCrossRefGoogle Scholar
  8. Pryce G, Male D, Campbell I, Greenwood J (1997) Factors controlling T-cell migration across rat cerebral endothelium in vitro. J Neuroimmunol 75: 84–94PubMedCrossRefGoogle Scholar
  9. Roitt I, Brostoff J, Male D (1998) Immunology, 5th ed. Mosby, LondonGoogle Scholar
  10. Van Schooten WC, Quan J (1993) The influence of LFA-1 on human T cells stimulated by solid phase immobilized HLA class II-peptide complexes. Scand J Immunol 38: 375–380PubMedCrossRefGoogle Scholar
  11. Vermot Desroches C, Rigal D, Andréoni C (1991) Regulation and functional involvement of distinct determinants of leucocyte Function-associated Antigen 1 (LFA-1) in T-cell activation in vitro. Scand J Immunol 33: 277–286PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • M. Empl
    • 1
  • P. Sostak
    • 1
  • M. Breckner
    • 2
  • M. Riedel
    • 2
  • N. Müller
    • 2
  • R. Gruber
    • 3
  • S. Förderreuther
    • 1
  • A. Straube
    • 1
  1. 1.Departments of NeurologyLudwig-Maximilians-UniversityMunichFederal Republic of Germany
  2. 2.Departments of PsychiatryLudwig-Maximilians-UniversityMunichFederal Republic of Germany
  3. 3.Departments of ImmunologyLudwig-Maximilians-UniversityMunichFederal Republic of Germany

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