T cell subsets and expression of integrins in peripheral blood of patients with migraine and chronic tension type headache
Neurogenic inflammation of durai vessels has been hypothesised to be an essential part of migraine physiopathology. Analysis of lymphocyte subpopulations and integrin expression in the peripheral blood of headache patients (migraine and chronic tension type headache) showed an elevated proportion of T-helper cells and T-helper memory cells as well as a higher expression of LFA-1 on T-helper and T-suppressor cells. This could be a sign of enhanced endothelium and lymphocyte interaction as it would be expected in an inflammatory process of cranial vessels.
KeywordsNeurogenic Inflammation Chronic Tension Type Headache Plasma Protein Extravasation Cranial Vessel Lymphocyte Interaction
Unable to display preview. Download preview PDF.
- Buzzi MG, Dimitriadou V, Theoharides TC, Moskowitz MA (1992) 5-Hydroxytryptamine receptor agonist for the abortive treatment of vascular headaches block mast cell, endothelial and platelet activation within the rat dura mater after trigeminal stimulation. Brain Res 583: 137–149PubMedCrossRefGoogle Scholar
- Dimitriadou V, Buzzi MG, Theoharides TC, Moskowitz MA (199D) Ultrastructural evidence for neurogenically mediated changes in blood vessels of the rat dura mater and tongue following antidromic trigeminal stimulation. Neuroscience 44: 97–112Google Scholar
- Roitt I, Brostoff J, Male D (1998) Immunology, 5th ed. Mosby, LondonGoogle Scholar