Neurochemie, Wirkmechanismus

  • Th. Müller
  • W. Kuhn
  • H. Przuntek


Acetylcholin als zerebraler Neurotransmitter kommt vor allem im Nucleus caudatus, Putamen, Nucleus interpeduncularis, Tuber-culum olfactorium, Nucleus accumbens, Nucleus basalis Meynert, in der Amygdala und in den motorischen Hirnnervenkernen vor. Peripher erscheint Acetylcholin in der glatten Muskulatur im Bereich der motorischen Endplatte, in den Drüsen und hier insbesondere in der Speicheldrüse und im Bereich des Auges (Clarke 1995). Da es schwierig ist, Acetylcholin selbst nachzuweisen, wird meist die Aktivität der Acetylcholintransferase des Cholin acetylierenden Enzyms bestimmt. Die Aktivität der Acetylcholintransferase korreliert in der Regel mit dem Acetylcholingehalt der einzelnen Hirnabschnitte.


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© Springer-Verlag Wien 1999

Authors and Affiliations

  • Th. Müller
  • W. Kuhn
  • H. Przuntek

There are no affiliations available

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