Donepezil (Donepezil Hydrochlorid) ist der zweite Acetylcholinesterase-Hemmer, der in Deutschland für die Behandlung von leichten und mittelschweren Demenzen vom Alzheimer-Typ zugelassen worden ist. Es handelt sich um einen Acetylcholinesterase-Hemmer vom Piperidin-Typ, der sich hinsichtlich seiner chemischen Struktur von anderen Cholinesterase-Hemmern wie Tacrin, einer Acridin-Verbindung oder Physostigmin, einem Carbamat, unterscheidet. Die Strukturformel ist der Abb. 12.3.1 zu entnehmen.


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© Springer-Verlag Wien 1999

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  • U. Hegerl

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