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Diagnostik

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Book cover Neuro-Psychopharmaka Ein Therapie-Handbuch

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Zusammenfassung

Verfahren zur bildhaften Darstellung des Gehirns sind Grundsteine zur Differentialdiagnostik der Demenzen. Sie veranschaulichen Struktur und Funktion des Gehirns mit einer früher nicht vorstellbaren räumlichen und zeitlichen Auflösung in einer Größenordnung von nur wenigen Millimetern, was die Kernspintomographie anbelangt. Der Größte Teil der Informationsverarbeitung im Gehirn vollzieht sich über Synapsen. Die funktionellen Methoden erfassen hauptsächlich ebenfalls synaptische Prozesse, oder solche, die direkt oder indirekt damit verbunden sind; dazu gehören vor allem Veränderungen von Durchblutung und Stoffwechsel. Bildgebende Verfahren können in drei Große Gruppen aufgeteilt wer den:

  1. a)

    die neurophysiologischen mit Elektroenzephalographie (EEG) und Magnetoenzephalographie (MEG),

  2. b)

    die nuklearmedizinischen mit Single Photon-Emission-Computer-Tomographie (SPECT) und Positronen-Emissions-Tomographie (PET) und

  3. c)

    die neuroradiologischen mit Computertomographie (CT), Kernspintomographie oder Magnetresonanztomographie (MRT), Magnetresonanzspektroskopie (MRS) und funktioneller Magnetresonanztomographie (fMRT).

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Literatur

  • Aichner F, Wagner M, Kremser C, Felber S (1996) MR-imaging of non-Alzheimer’s dementia. J Neural Transm [Suppl] 47: 143–153

    Article  CAS  Google Scholar 

  • Ambrose J (1973) Computerized transverse axial scanning (tomography). 2. Clinical application. Br J Radiol 46: 1023–1047

    Article  PubMed  CAS  Google Scholar 

  • Belliveau JW, Kennedy DNJ, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR (1991) Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254: 716–719

    Article  PubMed  CAS  Google Scholar 

  • Berger H (1929) On the electroencephalogram of man. Arch Psychiatr Nervenkr 87: 527–570

    Article  Google Scholar 

  • Bischoff C, VON Einstedel HG (1997) The significance of leukoaraiosis. A current evaluation and differential diagnosis. Nervenarzt 68: 609–619

    Article  PubMed  CAS  Google Scholar 

  • Brooks DJ (1993) PET studies on the early and differential diagnosis of Parkinson’s disease. Neurology 43: S6–16

    Google Scholar 

  • Caplan LR (1995) Binswanger’s disease-revisited. Neurology 45: 626–633

    Article  PubMed  CAS  Google Scholar 

  • Claus JJ, Dubois EA, Booij J, Habraken J, De Munck JC, VAN Herk M, Verbeeten BJ, VAN Royen EA (1997) Demonstration of a reduction in muscarinic receptor binding in early Alzheimer’s disease using iodine-123 dexetimide single-photon emission tomography. Eur J Nucl Med 24: 602–608

    PubMed  CAS  Google Scholar 

  • Davis PC, Mirra SS, Alazraki N (1994) The brain in older persons with and without dementia: findings on MR, PET, and SPECT images. AJR Am J Roentgenol 162: 1267–1278

    PubMed  CAS  Google Scholar 

  • Dhawan V, Ishikawa T, Patlak C, Chaly T, Robeson W, Belakhlef A, Margouleff C, Mandel F, Eidelberg D (1996) Combined FDOPA and 30MFD PET studies in Parkinson’s disease. J Nucl Med 37: 209–216

    PubMed  CAS  Google Scholar 

  • Dierks T, Perisic I, Froelich L, Ihl R, Maurer K (1991) Topography of quantitative EEG in dementia of Alzheimer Type: relation to severity of dementia. Psychiatry Res Neuroimaging 40 (3): 181–194

    Article  CAS  Google Scholar 

  • Dierks T, Ihl R, Frölich L, Maurer K (1993) Dementia of Alzheimer type (DAT): effects on the spontaneous EEG described by dipole sources. Psychiatry Res Neuroimaging 50: 151–162

    Article  CAS  Google Scholar 

  • Dierks T, Jelic V, Julin P, Maurer K, Wahlund LO, Almkvist O, Strik WK, Winblad B (1997) EEG-microstates in mild memory impairment and Alzheimer’s disease: possible association with disturbed information processing. J Neural Transm 104: 483–495

    Article  PubMed  CAS  Google Scholar 

  • Dierks T, Linden DE, Hertel A, Günther T, Lanfermann H, Niesen A, Frölich L, Zanella FE, Hor G, Goebel R, Maurer K (1998) Multimodal imaging of residual function and compensatory resource allocation in cortical atrophy: a case study of parietal lobe function in a patient with Huntington’s disease. Psychiatry Res 84 (1): 27–35

    Article  PubMed  CAS  Google Scholar 

  • Duara R, Barker W, Loewenstein D, Pascal S, Bowen B (1989) Sensitivity and specificity of positron emission tomography and magnetic resonance imaging studies in Alzheimer’s disease and multi-infarct dementia. Eur Neurol 29: 9–15

    Article  PubMed  Google Scholar 

  • Duffy FH, Mcanulty G, Albert MS (1995) Temporoparietal electrophysiological differences characterize patients with Alzheimer’s disease: a split-half replication study. Cerebral Cortex 3: 215–221

    Article  Google Scholar 

  • Eberling JL, Richardson BC, Reed BR, Wolfe N, Jagust WJ (1994) Cortical glucose metabolism in Parkinson’s disease without dementia. Neurobiol Aging 15: 329–335

    Article  PubMed  CAS  Google Scholar 

  • Foster NL (1994) PET imaging. In: Terry RD, Katzmann R, Bick KL (eds) Alzheimer disease. Raven Press, New York, pp 87–103

    Google Scholar 

  • Fox NC, Freeborough PA, Rossor MN (1996) Visualisation and quantification of rates of atrophy in Alzheimer’s disease. Lancet 348: 94–97

    Article  PubMed  CAS  Google Scholar 

  • Grunwald F, Pohl C, Bender H, Hartmann A, Menzel C, Ruhlmann J, Keller E, Biersack HJ (1996) 18F-fluorodeoxyglucose-PET and 99mTc-bicisate-SPECT in Creutzfeldt-Jakob disease. Ann Nucl Med 10: 131–134

    Article  PubMed  CAS  Google Scholar 

  • Hampel H, Teipel SJ, Kotter HU, Horwitz B, Pfluger T, Mager T, Moller HJ, Muller-Spahn F (1997) Structural magnetic resonance tomography in diagnosis and research of Alzheimer type dementia. Nervenarzt 68: 365–378

    Article  PubMed  CAS  Google Scholar 

  • Hauser RA, Olanow GW (1994) Magnetic resonance imaging of neurodegenerative diseases. J Neuroimaging 4: 146–158

    PubMed  CAS  Google Scholar 

  • Haxby JV, Grady CL, Duara R, Schlageter N, Berg G, Rapoport SI (1986) Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer’s-type dementia. Arch Neurol 43: 882–885

    Article  PubMed  CAS  Google Scholar 

  • Haxby JV, Grady CL, Koss E, Horwitz B, Heston L, Schapiro M, Friedland RP, Rapoport SI (1990) Longitudinal study of cerebral metabolic asymmetries and associated neuropsychological patterns in early dementia of the Alzheimer type. Arch Neurol 47: 753–760

    Article  PubMed  CAS  Google Scholar 

  • Heiss WD, Kessler J, Szelies B, Grond M, Fink G, Herholz K (1991) Positron emission tomography in the differential diagnosis of organic dementias. J Neural Transm [Suppl] 33: 13–19

    CAS  Google Scholar 

  • Hoffman JM (1997) Positron emission tomography studies in dementia. In: Krishnan KR, Doraiswamy PM (eds) Brain imaging in clinical psychiatry. Marcel Dekker, New York Basel Hong Kong, pp 553–573

    Google Scholar 

  • Hounsfield GN (1973) Computerized transverse axial scanning (tomography). 1. Description of system. Br J Radiol 46: 1016–1022

    Article  PubMed  CAS  Google Scholar 

  • Jagust WJ, Eberling JL, Reed BR, Mathis CA, Budinger TF (1997) Clinical studies of cerebral blood flow in Alzheimer’s disease. Ann NY Acad Sci 826: 254–262

    Article  PubMed  CAS  Google Scholar 

  • Kamo H, Mcgeer PL, Harrop R, Mcgeer EG, Calne DB, Martin WR, Pate BD (1987) Positron emission tomography and histopathology in Pick’s disease. Neurology 37: 439–445

    Article  PubMed  CAS  Google Scholar 

  • Keshavan MS, Kapur S, Pettegrew JW (1991) Magnetic resonance spectroscopy in psychiatry: potential, pitfalls, and promise. Am J Psychiatry 148: 976–985

    PubMed  CAS  Google Scholar 

  • Kushner M, Alavi A, Reivich M, Dann R, Burke A, Robinson G (1984) Contralateral cerebellar hypometabolism following cerebral insult: a positron emission tomographic study. Ann Neurol 15: 425–434

    Article  PubMed  CAS  Google Scholar 

  • Kuwabara H, Cumming P, Yasuhara Y, Leger GC, Guttman M, Diksic M, Evans AC, Gjedde A (1995) Regional striatal DOPA transport and decarboxylase activity in Parkinson’s disease. J Nucl Med 36: 1226–1231

    PubMed  CAS  Google Scholar 

  • Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89: 5675–5679

    Article  PubMed  CAS  Google Scholar 

  • Laakso MP, Soininen H, Partanen K, Helkala EL, Hartikainen P, Vainio P, Hallikainen M, Hanninen T, Riekkinen PJS (1995) Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer’s disease: correlation with memory functions. J Neural Transm [PD-Sect] 9: 73–86

    Article  CAS  Google Scholar 

  • Lang C, Herholz K, Huk W, Feistel H (1990) Diagnostic differentiation of dementia diseases by modern imaging procedures. Fortschr Neurol Psychiatr 58: 380–398

    Article  PubMed  CAS  Google Scholar 

  • Lauterbur PC (1973) Image formation by induced local interactions: examples employing nuclear magnetic resonance. Nature 242: 190–191

    Article  CAS  Google Scholar 

  • Loeb C, Meyer JS (1996) Vascular dementia: still a debatable entity? J Neurol Sci 143: 31–40

    Article  PubMed  CAS  Google Scholar 

  • Mielke R, Pietrzyk U, Jacobs A, Fink GR, Ichimiya A, Kessler J, Herholz K, Heiss WD (1994) HMPAO SPET and FDG PET in Alzheimer’s disease and vascular dementia: comparison of perfusion and metabolic pattern. Eur J Nucl Med 21: 1052–1060

    Article  PubMed  CAS  Google Scholar 

  • Mielke R, Kessler J, Szelies B, Herholz K, Wienhard K, Heiss WD (1996) Vascular dementia: perfusional and metabolic disturbances and effects of therapy. J Neural Transm [Suppl] 47: 183–191

    Article  CAS  Google Scholar 

  • Morrish PK, Sawle GV, Brooks DJ (1996) An [18F]dopa-PET and clinical study of the rate of progression in Parkinson’s disease. Brain 119: 585–591

    Article  PubMed  Google Scholar 

  • Nordberg A (1996) Functional studies of new drugs for the treatment of Alzheimer’s disease. Acta Neurol Scand [Suppl] 165: 137–144

    Article  CAS  Google Scholar 

  • Nordberg A, Lilja A, Lundqvist H, Hartvtg P, Amberla K, Viitanen M, Warpman U, Johansson M, Hellstrom-Lindahl E, Bjurling P (1992) Tacrine restores cholinergic nicotinic receptors and glucose metabolism in Alzheimer patients as visualized by positron emission tomography. Neurobiol Aging 13: 747–758

    Article  PubMed  CAS  Google Scholar 

  • Nordberg A, Lundqvist H, Hartvig P, Andersson J, Johansson M, Hellstrom-Lindahl E, Langstrom B (1997) Imaging of nicotinic and muscarinic receptors in Alzheimer’s disease: effect of tacrine treatment. Dement Geriatr Cogn Disord 8: 78–84

    Article  PubMed  CAS  Google Scholar 

  • Pantoni L, Garcia JH (1995) The significance of cerebral white matter abnormalities 100 years after Binswanger’s report. A review. Stroke 26: 1293–1301

    Article  CAS  Google Scholar 

  • Rapoport SI (1991) Positron emission tomography in Alzheimer’s disease in relation to disease pathogenesis: a critical review. Cerebrovasc Brain Metab Rev 3: 297–335

    PubMed  CAS  Google Scholar 

  • Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D (1996) Preclinical evidence of Alzheimer’s disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 334: 752–758

    Article  PubMed  CAS  Google Scholar 

  • Renshaw PF, Levin JM, Kaufman MJ, Ross MH, Lewis RF, Harris GJ (1997) Dynamic susceptibility contrast magnetic resonance imaging in neuropsychiatry: present utility and future promise. Eur Radiol 7: 216–221

    Article  PubMed  Google Scholar 

  • Riekkinen PJ, Riekkinen PJJR, Soininen H, Reinikainen K, Laulumaa V, Partanen J, Halonen T, Paljärvi L (1990) Regulation of EEG delta activity by the cholinergic nucleus basalis. In: Maurer K, Riederer P, Beckmann H (eds) Alzheimer’s disease. Epidemiology, neuropathology, neurochemistry, and clinics. Springer, Wien New York, pp 437–445

    Google Scholar 

  • Ryding E (1996) SPECT measurements of brain function in dementia; a review. Acta Neurol Scand [Suppl] 168: 54–58

    Article  CAS  Google Scholar 

  • Saha GB, Macintyre WJ, Go RT (1994) Radiopharmaceuticals for brain imaging. Semin Nucl Med 24: 324–349

    Article  PubMed  CAS  Google Scholar 

  • Schlegel S, Kretzschmar K (1997) Value of computerized tomography and magnetic resonance tomography in psychiatric diagnosis. Nervenarzt 68: 1–10

    Article  PubMed  CAS  Google Scholar 

  • Slansky I, Herholz K, Pietrzyk U, Kessler J, Grond M, Mielke R, Heiss WD (1995) Cognitive impairment in Alzheimer’s disease correlates with ventricular width and atrophy-corrected cortical glucose metabolism. Neuroradiology 37: 270–277

    Article  PubMed  CAS  Google Scholar 

  • Smith AD, Jobst KA (1996) Use of structural imaging to study the progression of Alzheimer’s disease. Br Med Bull 52: 575–586

    Article  PubMed  CAS  Google Scholar 

  • Smith GS, De Leon MJ, George AB, Kluger A, Volkow ND, Mcrae T, Golomb J, Ferris SH, Reisberg B, Ciaravino J (1992) Topography of cross sectional and longitudinal glucose metabolic deficits in Alzheimer’s disease. Pathophysiologic implications. Arch Neurol 49: 1142–1150

    Article  PubMed  CAS  Google Scholar 

  • Soininen H, Partanen J, Paakonen A, Koivisto E, Riekkinen PJ (1991) Changes in absolute power values of EEG spectra in the follow-up of Alzheimer’s disease. Acta Neurol Scand 83: 133–136

    Article  PubMed  CAS  Google Scholar 

  • Steffens DC (1997) MRI and MRS in dementia. In: Krishnan KR, Doraiswamy PM (eds) Brain imaging in clinical psychiatry. Marcel Dekker, New York Basel Hong Kong, pp 503–532

    Google Scholar 

  • Stewart DJ, Macfabe DF, Vanderwolf CH (1984) Cholinergic activation of the electrocorticogram role of the substantia innomiata and effects of atropine and quinuclidinyl benzilate. Brain Res 322: 219–232

    Article  PubMed  CAS  Google Scholar 

  • Strik W, Lehmann D (1993) Data-determined window size and space-oriented segmentation of spontaneous EEG map series. Electroencephalogr Clin Neurophysiol 87: 169–174

    Article  PubMed  CAS  Google Scholar 

  • Szelies B, Mielke R, Herholz K, Heiss WD (1994) Quantitative topographical EEG compared to FDG PET for classification of vascular and degenerative dementia. Electroencephalogr Clin Neurophysiol 91: 131–139

    Article  PubMed  CAS  Google Scholar 

  • Vander BT, Minoshima S, Giordani B, Foster NL, Frey KA, Berent S, Albin RE, Koeppe RA, Kuhl DE (1997) Cerebral metabolic differences in Parkinson’s and Alzheimer’s diseases matched for dementia severity. J Nucl Med 38: 797–802

    Google Scholar 

  • Waldemar G, Hogh P, Paulson OB (1997) Functional brain imaging with single-photon emission computed tomography in the diagnosis of Alzheimer’s disease. Int Psychogeriatr 9: 223–227

    Article  PubMed  Google Scholar 

  • Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, Delong MR (1982) Alzheimer’s disease and senile dementia: loss of neurons in the basal forebrain. Science 215: 1237–1239

    Article  PubMed  CAS  Google Scholar 

  • Young SW (1984) Nuclear magnetic resonance imaging: basic principles. Raven Press, New York

    Google Scholar 

Literatur

  • Alzheimer A (1907) über eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiatr 64: 146–148

    Google Scholar 

  • Baddeley A, Dalla Sala S, Spinnler H (1991) The two-component hypothesis of memory deficit in Alzheimer’s disease. J Clin Exp Neuropsychol 13: 327–380

    Article  Google Scholar 

  • Bakchine S, Lacomblez L, Palisson E et al. (1989) Relationship between primitive reflexes, extrapyramidal signs, reflective apraxia and severity of cognitive impairment in dementia of the Alzheimer type. Acta Neurol Scand 79: 38–46

    Article  PubMed  CAS  Google Scholar 

  • Bayles KA (1984) Language and dementia. In: Holland A (ed) Language disorders in adults. College Hill Press, Diego, pp 209–244

    Google Scholar 

  • Bayles KA (1991) Age at onset of Alzheimer’s disease. Relation to language dysfunction. Arch Neurol 48: 155–159

    Article  PubMed  CAS  Google Scholar 

  • Benson DF, Cummings JL, Tsai SY (1982) Angular gyrus syndrome simulating Alzheimer’s disease. Arch Neurol 39: 616–620

    Article  PubMed  CAS  Google Scholar 

  • Bergeron C, Ranalli PJ, Miceli PN (1987) Amyloid angiopathy in Alzheimer’s disease. Can J Neurol Sci 14: 564–569

    PubMed  CAS  Google Scholar 

  • Blessed G, Tomlinson BE, Roth M (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 114: 797–811

    Article  PubMed  CAS  Google Scholar 

  • Brandt J, Rich JB (1995) Memory disorders in the dementias. In: Baddeley AD, Wilson BA, Watts FN (eds) Handbook of memory disorders. Wiley, Chichester, pp 243–270

    Google Scholar 

  • Brun A, Englund E (1981) Regional pattern of degeneration in Alzheimer’s disease: neuronal loss and histopathological grading. Histopathology 5: 549–564

    Article  PubMed  CAS  Google Scholar 

  • Chandra V, Bharucha NE, Schoenberg BS (1986) Conditions associated with Alzheimer’s disease at death: case-control study. Neurology 19: 68–74

    Google Scholar 

  • Chatterjee A, Strauss ME, Smyth KA, Whitehouse PJ (1992) Personality changes in Alzheimer’s disease. Arch Neurol 49: 486–491

    Article  PubMed  CAS  Google Scholar 

  • Chawluk JB, Mesulam MM, Hurtig H et al. (1986) Slowly progressive aphasia without generalized dementia: studies with positron emission tomography. Ann Neurol 19: 68–74

    Article  PubMed  CAS  Google Scholar 

  • Cummings JL, Benson DF, Hill MA, Read S (1985) Aphasia in dementia of the Alzheimer type. Neurology 35: 394–397

    Article  PubMed  CAS  Google Scholar 

  • Cummings JH, Houlian JP, Hill MA (1986) The pattern of reading deterioration in dementia of the Alzheimer type: observations and implications. Brain Lang 29: 315–323

    Article  PubMed  CAS  Google Scholar 

  • De Ajuriaguerra J, Gauthier G (1964) Etude de la désorganisation motorice dans un groupe de déments seniles alzheimerisés. Med Hyg 22: 409–410

    Google Scholar 

  • De Ajuriaguerra J, Kluser JP, Velghe J, Tissot R (1965) Praxies idéatoires et permanence de l’object. Quelques aspects de leur desintégration conjointe dans les syndromes démentiels du grand age. Psychiat Neurol (Basel) 150: 306–319

    Article  Google Scholar 

  • Della Sala S, Lucchelli F, Spinnler H (1987) Ide-omotor apraxia in patients with dementia of Alzheimer type. J Neurol 234: 91–93

    Article  PubMed  CAS  Google Scholar 

  • Diesfeldt HFA (1989) Semantic impairment in senile dementia of the Alzheimer type. Aphasiology 3: 41–54

    Article  Google Scholar 

  • Duara R, Lopez-Alberola RF, Barker WW, Loewenstein DA, Zatinsky M, Eisdorfer CE, Weinberg GB (1993) A comparison off amilial and sporadic Alzheimer’s disease. Neurology 43: 1377–1384

    Article  PubMed  CAS  Google Scholar 

  • Edwards DF, Deuel RK, Baum CM, Morris JC (1991) A quantitative analysis of apraxia in senile dementia of the Alzheimer-type: stage-related differences in prevalence and type. Dementia 2: 142–149

    Google Scholar 

  • Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, Chown MJ, Hebert LE, Hennekens CH, Taylor JO (1989) Prevalence of Alzheimer’s disease in a community population of older persons: higher than previously reported. J Am Med Assoc 262: 2551–2556

    Article  CAS  Google Scholar 

  • Fitch N, Becker R, Heller A (1988) The inheritance of Alzheimer’s disease: a new interpretation. Ann Neurol 23: 14–19

    Article  PubMed  CAS  Google Scholar 

  • Franssen EH, Reisberg B, Kluger A, Sinaiko E, Boja C (1991) Cognition-independent neurologic symptoms in normal aging and probable Alzheimer’s disease. Arch Neurol 48: 148–154

    Article  PubMed  CAS  Google Scholar 

  • Gabrieli JDE, Keane MM, Stanger BZ, Kjelgaard MM, Corkin S, Growdon JH (1994) Dissociations among structural-perceptual, lexical-semantic, and event-fact memory systems in Alzheimer, amnesic, and normal subjects. Cortex 30: 75–103

    PubMed  CAS  Google Scholar 

  • Goudsmit JAAP, White BJ, Weitkamp LR, Keats BJB, Morrow CH, Gajdusek DC (1981) Familial Alzheimer’s disease in two kindreds of the same geographic and ethnic origin: a clinical and genetic study. J Neurol Sci 49: 79–89

    Article  PubMed  CAS  Google Scholar 

  • Hauser WA, Morris ML, Heston LL, Anderson VE (1986) Seizures and myoclonus in patients with Alzheimer’s disease. Neurology 36: 1226–1230

    Article  PubMed  CAS  Google Scholar 

  • Haxby JV (1990) Cognitive deficits and local metabolic changes in dementia of Alzheimer type. In: Rapoport SR, Petit H, Leys D, Christen Y (eds) Imaging, cerebral topography and Alzheimer’s disease. Springer, Berlin Heidelberg New York Tokyo, pp 109–119

    Chapter  Google Scholar 

  • Henderson VW, Mack W, Williams BW (1989) Spatial disorientation in Alzheimer’s disease. Arch Neurol 46: 391–394

    Article  PubMed  CAS  Google Scholar 

  • Hier B, Hagenlocker K, Shindler AG (1985) Language disintegration in dementia: effects of etiology and severity. Brain Lang 25: 117–133

    Article  PubMed  CAS  Google Scholar 

  • Homer J, Heyman A, Dawson D, Rogers H (1988) The relationship of agraphia to the severity of dementia in Alzheimer’s disease. Arch Neurol 45: 760–763

    Article  Google Scholar 

  • Huff FJ, Corkin S (1984) Recent advances in the neuropsychology of Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiatry 8: 643–648

    Article  PubMed  CAS  Google Scholar 

  • Joachim CL, Morris HJ, Selkoe DJ (1988) Clinically diagnosed Alzheimer’s disease: autopsy results in 150 cases. Ann Neurol 24: 50–56

    Article  PubMed  CAS  Google Scholar 

  • Kaszniak AW, Wilson RS, Foy JH, Stebbins GT (1986) Cognitive assessment in Alzheimer’s disease: cross-sectional and longitudinal perspectives. Can J Neurol Sci 13 [Suppl 4]: 420–423

    PubMed  CAS  Google Scholar 

  • Kaye JA, May C, Daly E, Atack JR, Sweeney BS, Luxenberg JS, Kat AD, Kaufman S, Milstein S, Friedland RP, Rapoport SI (1988) Cerebrospinal fluid monoamine markers are decreased in dementia of the Alzheimer type with extrapyramidal features. Neurology 38: 554–557

    Article  PubMed  CAS  Google Scholar 

  • Kertesz A, Appell J, Fisman M (1986) The dissolution of language in Alzheimer’s disease. Can J Neurol Sci 13 [Suppl 4]: 415–418

    PubMed  CAS  Google Scholar 

  • Kopelman MD (1991) Frontal dysfunction and memory deficits in the alcoholic Korsakoff syndrome and Alzheimer-type dementia. Brain 114: 117–137

    PubMed  Google Scholar 

  • Lange KW, Sahakian BJ, Quinn NP, Marsden CD, Robbins TW (1995) Comparison of executive and visuospatial memory function in Huntington’s disease and dementia of Alzheimer type matched for degree of dementia. J Neurol Neurosurg Psychiatry 58: 598–606

    Article  PubMed  CAS  Google Scholar 

  • Martin A, Fedio P (1983) Word production and comprehension in Alzheimer’s disease: the breakdown of semantic knowledge. Brain Language 19: 124–141

    Article  CAS  Google Scholar 

  • Mckhann G, Drachman D, Folstein M, Katzman R, Price D, Stadian E (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 34: 939–944

    Article  PubMed  CAS  Google Scholar 

  • Mendez MF, Zander BA (1991) Dementia presenting with aphasia: clinical characteristics. J Neurol Neurosurg Psychiatry 54: 542–545

    Article  PubMed  CAS  Google Scholar 

  • Mendez MF, Mendez MA, Martin R, Smyth KA, Whitehouse FJ (1990) Complex visual disturbances in Alzheimer’s disease. Neurology 40: 439–443

    Article  PubMed  CAS  Google Scholar 

  • Mesulam M (1982) Slowly progressive aphasia without generalized dementia. Ann Neurol 11: 592–598

    Article  PubMed  CAS  Google Scholar 

  • Miller E (1971) On the nature of memory disorder in presenile dementia. Neuropsychologia 9: 75–81

    Article  PubMed  CAS  Google Scholar 

  • Molsa PK, Maritila RJ, Rinne UK (1984) Extrapyramidal signs in Alzheimer’s disease. Neurology 34: 1114–1116

    Article  PubMed  CAS  Google Scholar 

  • Morris JC, Mckeel DW, Storandt M, Rubin EH, Price JL, Grant EA, Ball MJ, Berg L (1991) Very mild Alzheimer’s disease: informant-based clinical, psychometric, and pathologic distinction from normal aging. Neurology 41: 469–478

    Article  PubMed  CAS  Google Scholar 

  • Moscovitch M, Vriezen E, Goshen-Gottstein Y (1993) Implicit tests of memory in patients with focal lesions or degenerative brain disorders. In: Boller F, Grafman J (eds) Handbook of neuropsychology, vol 8. Elsevier, Amsterdam, pp 133–173

    Google Scholar 

  • Muramoto O (1984) Selective reminding in normal and demented aged people: auditory verbal versus visual spatial task. Cortex 20: 461–478

    PubMed  CAS  Google Scholar 

  • Nebes RD, Brady CB (1989) Focused and divided attention in Alzheimer’s disease. Cortex 25: 305–315

    PubMed  CAS  Google Scholar 

  • Nebes RD, Brady CB (1993) Phasic and tonic alertness in Alzheimer’s disease. Cortex 29: 77–90

    PubMed  CAS  Google Scholar 

  • Nestor PG, Parasuraman R, Haxby JV (1991) Speed of information processing and attention in early Alzheimer’s dementia. Dev Neuropsychol 7: 243–256

    Article  Google Scholar 

  • Ober BA, Dronkers NF, Koss E, Delis DC, Friedland RP (1986) Retrieval from semantic memory in Alzheimer-type dementia. J Clin Exp Neuropsychol 8: 75–92

    Article  PubMed  CAS  Google Scholar 

  • O’Conner KP (1980a) Slow potential correlates of attention dysfunction in senile dementia, I. Biol Psychol 11: 193–202

    Article  PubMed  Google Scholar 

  • O’Conner KP (1980b) Slow potential correlates of attention dysfunction in senile dementia, II. Biol Psychol 11: 203–216

    Article  Google Scholar 

  • Pearce J, Miller E (1973) Clinical aspects of dementia. Baillière Tindall, London

    Google Scholar 

  • Petry S, Cummings JL, Hill MA, Shapira J (1988) Personality alterations in dementia of the Alzheimer type. Arch Neurol 45: 1187–1190

    Article  PubMed  CAS  Google Scholar 

  • Pirozzolo FJ, Christensen KJ, Ogl KM, Hansch EC, Thompson WE (1981) Simple and choice reaction time in dementia: clinical implications. Neurobiol Aging 2: 113–117

    Article  PubMed  CAS  Google Scholar 

  • Poeck K, Luzzati C (1988) Slowly progressive aphasia in three patients. The problem of accompanying neurological deficit. Brain 111: 151–168

    Article  PubMed  Google Scholar 

  • Rapcsak SZ, Croswell SC, Rubens AB (1989) Apraxia in Alzheimer’s disease. Neurology 39: 664–668

    Article  PubMed  CAS  Google Scholar 

  • Reding M, Haycox J, Blass J (1985) Depression in patients refferred to a dementia clinic: a three-year prospective study. Arch Neurol 42: 894–896

    Article  PubMed  CAS  Google Scholar 

  • Reifler BV, Larson E, Hanley R (1982) Coexistence of cognitive impairment and depression in geriatric outpatients. Am J Psychiatry 139: 623–626

    PubMed  CAS  Google Scholar 

  • Ripich DN, Vertes D, Whitehouse P, Fulton S, Ekelman B (1991) Turn-taking and speech act patterns in the discourse of senile dementia of’ the Alzheimer’s type patients. Brain Lang 40: 330–342

    Article  PubMed  CAS  Google Scholar 

  • Rissenberg M, Glanzer M (1987) Free recall and word finding ability in normal aging and senile dementia of the Alzheimer’s type: the effect of item concreteness. J Gerontol 42: 318–322

    Article  PubMed  CAS  Google Scholar 

  • Rubin EH, Morris JC, Storandt M, Berg L (1987) Behavioural changes in patients with mild senile dementia of the Alzheimer type. Psychiatry Res 21: 55–62

    Article  PubMed  CAS  Google Scholar 

  • Sagar HJ, Cohen NJ, Sullivan EG, Corkin S, Growdon JH (1988) Remote memory function in Alzheimer’s disease and Parkinson’s disease. Brain 111: 185–206

    Article  PubMed  Google Scholar 

  • Sim M, Turner E, Smith WT (1966) Cerebral biopsy in the investigation of presenile dementia. 1. Clinical aspects. Br J Psychiatry 112: 119–125

    Article  PubMed  CAS  Google Scholar 

  • Sjögren T, Sjögren H, Lindgren AGH (1952) Morbus Alzheimer and morbus Pick. A genetic, clinical and pathoanatomical study. Acta Psychiatr Neurol Scand [Suppl] 82: 1–152

    Google Scholar 

  • Terry RD, Katzman R (1983) Senile dementia of the Alzheimer type. Ann Neurol 14: 497–506

    Article  PubMed  CAS  Google Scholar 

  • Thal LJ, Grundman M, Klauber MR (1988) Dementia: characteristics of a referral population and factors associated with progression. Neurology 38: 1083–1090

    Article  PubMed  CAS  Google Scholar 

  • Tierney MC, Fisher RH, Lewis AJ, Zorzitto ML, Snow WG, Reid DW, Nieuwstraten P (1988) The NINCDS-ADRDA work group criteria for the clinical diagnosis of probable Alzheimer’s disease: a clinicopathologic study of 57 cases. Neurology 38: 359–364

    Article  PubMed  CAS  Google Scholar 

  • Weingartner H, Kaye W, Smallberg SA, Ebert MH, Gillin JCC, Sitaran N (1981) Memory failures in progressive idiopathic dementia. J Abnorm Psychol 90: 187–196

    Article  PubMed  CAS  Google Scholar 

  • Weingartner H, Grafman J, Boutelle W, Kaye W, Martin PR (1983) Forms of memory failure. Science 221: 380–382

    Article  PubMed  CAS  Google Scholar 

  • Wilson RS, Kaszniak AW, Fox JH (1981) Remote memory in senile dementia. Cortex 17: 41–48

    PubMed  CAS  Google Scholar 

  • Wilson RS, Kaszniak AW, Bacon LD, Fox JH, Kelly MP (1982) Facial recognition memory in dementia. Cortex 18: 329–336

    PubMed  CAS  Google Scholar 

  • Wilson RS, Bacon LD, Fox JH (1983a) Primary and secondary memory in dementia of the Alzheimer type. J Clin Neuropsychol 5: 337–344

    Article  PubMed  CAS  Google Scholar 

  • Wilson RS, Bacon LD, Kramer RL, Fox JH, Kaszniak AW (1983b) Word frequency effect and recognition memory in dementia of the Alzheimer type. J Clin Neuropsychol 5: 97–104

    Article  PubMed  CAS  Google Scholar 

  • Wolf-Klein GP, Silverstone FA, Levy AP, Brod MS (1989) Screening for Alzheimer’s disease by clock dranging. J Am Geriatr Soc 37: 730–734

    PubMed  CAS  Google Scholar 

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Authors
  1. T. Dierks
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  2. K. Maurer
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  3. K. W. Lange
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  4. O. Tucha
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  5. T. Becker
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Editor information

Editors and Affiliations

  1. Klinische Neurochemie, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Würzburg, Bundesrepublik Deutschland

    Peter Riederer

  2. Bezirkskrankenhaus Gabersee, Wasserburg/Inn, Bundesrepublik Deutschland

    Gerd Laux

  3. Wien, Österreich

    Walter Pöldinger

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© 1999 Springer-Verlag Wien

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Dierks, T., Maurer, K., Lange, K.W., Tucha, O., Becker, T. (1999). Diagnostik. In: Riederer, P., Laux, G., Pöldinger, W. (eds) Neuro-Psychopharmaka Ein Therapie-Handbuch. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6400-6_49

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  • DOI: https://doi.org/10.1007/978-3-7091-6400-6_49

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7315-2

  • Online ISBN: 978-3-7091-6400-6

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