Neuroprotective effect of chronic inactivation of the subthalamic nucleus in a rat model of Parkinson’s disease

  • B. Piallat
  • A. Benazzouz
  • A. L. Benabid
Conference paper
Part of the 6th International Winter Conference on N eurodegeneration book series (NEURAL SUPPL, volume 55)


Several evidences showed that glutamate can be implicated in the degenerative process of dopaminergic neurons in Parkinson’s disease. The treatment with NMDA antagonists have been shown to induce a neuroprotective effect in animal models of this disease. As subthalamic nucleus neurons send direct glutamatergic projections to the substantia nigra, we studied the effects of kainic acid lesion of this nucleus on the degeneration of dopaminergic neurons induced by microinjection of 6-hydroxydopamine in the striatum of rat done one week after the first lesion. Animals were killed 15 days after the injection of 6-hydroxydopamine. Immunohistochemical study showed that lesion of the subthalamic nucleus can prevent the degeneration of substantia nigra dopaminergic somata when carried out one week prior to 6-hydroxydopamine injection in the striatum. Nevertheless neurochemical results showed that this lesion did not antagonize the striatal 6-hydroxydopamine-induced dopamine depletion in the striatum 15 days after 6-hydroxydopamine injection.


Kainic Acid Subthalamic Nucleus NMDA Antagonist High Frequency Stimulation Lesion Side 
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Copyright information

© Springer-Verlag/Wien 1999

Authors and Affiliations

  • B. Piallat
    • 1
  • A. Benazzouz
    • 1
  • A. L. Benabid
    • 1
  1. 1.Laboratoire de Neurobiologie Préclinique, INSERM U.318CHUGrenoble Cedex 09France

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