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Myelin dysfunction/degradation in the central nervous system: why are myelin sheaths susceptible to damage?

  • Monika Bradl
Conference paper
Part of the 6th International Winter Conference on N eurodegeneration book series (NEURAL SUPPL, volume 55)

Summary

In the central nervous system, myelin sheaths are produced to electrically insulate axons and to increase the velocity of axonal conduction. They are highly complex structures, which are often destructed in neurological disorders. One possible reason for the vulnerability of myelin sheaths to damage became apparent from analyses of animals with altered amounts of otherwise normal myelin components: Due to limited redundance in function between different myelin proteins, dysfunction or loss of one protein may cause loss of function and instability of the entire myelin sheath.

Keywords

Myelin Basic Protein Myelin Sheath Myelin Protein Proteolipid Protein Axonal Conduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1999

Authors and Affiliations

  • Monika Bradl
    • 1
  1. 1.Abteilung NeuroimmunologieMax-Planck-Institut für NeurobiologieMartinsriedFederal Republic of Germany

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