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Advances in Research on Neurodegeneration pp 131–147Cite as

Somatic gene therapy in animal models of Parkinson’s disease

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Part of the book series: 6th International Winter Conference on N eurodegeneration ((NEURAL SUPPL,volume 55))

Summary

Gene therapy in Parkinson’s disease (PD) emerged about 10 years ago but until now, no clinical trials are under way, because most approaches have failed to show long-term therapeutic effects in PD animal models and because safety concerns precluded the use in humans so far. This review tries to give an overview on the development of different strategies in gene therapy in PD animal models and point out new and possibly more successful directions, including the transplantation of neural precursor cells and pig tissue.

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Authors and Affiliations

  1. Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Federal Republic of Germany

    M. Bauer & PD Dr. med. T. Gasser

  2. Department of Medical Genetics, Ludwig-Maximilians-University, Munich, Federal Republic of Germany

    M. Ueffing & T. Meitinger

  3. Institute for Molecular Biology and Tumour Genetics, GSF, Munich, Federal Republic of Germany

    M. Ueffing

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  1. Universitätsklinik für Neurologie, Innsbruck, Österreich

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Bauer, M., Ueffing, M., Meitinger, T., Gasser, T. (1999). Somatic gene therapy in animal models of Parkinson’s disease. In: Poewe, W., Ransmayr, G. (eds) Advances in Research on Neurodegeneration. 6th International Winter Conference on N eurodegeneration, vol 55. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6369-6_12

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  • DOI: https://doi.org/10.1007/978-3-7091-6369-6_12

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83261-5

  • Online ISBN: 978-3-7091-6369-6

  • eBook Packages: Springer Book Archive

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