Free radical scavengers: chemical concepts and clinical relevance

  • Michael Gassen
  • M. B. H. Youdim
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 56)


Free radicals are involved in the pathology of many CNS disorders, like Parkinson’s disease, Alzheimer’s disease, or stroke. This discovery lead to the development of many radical scavengers for the clinical treatment of neurodegenerative diseases. In this review, the different chemical concepts for free radical scavenging will be discussed: nitrons, thiols, iron chelators, phenols, and catechols. Especially catechols, like the naturally occurring flavonols, the synthetic drug nitecapone, or the endogenous catacholamines and their metabolites, are of great interest, as they combine iron chelating with radical scavenging activity. We present data on the radical scvenging activity of dopamine and apomorphine, which prevent lipid peroxidation in rat brain mitochondria and protect PC12 cells against H2O2-toxicity.


PC12 Cell Free Radical Scavenger Iron Chelator Semiquinone Radical Protect PC12 Cell 


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Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • Michael Gassen
    • 1
  • M. B. H. Youdim
    • 2
  1. 1.Biomedical Research CNSMerck KGaADarmstadtFederal Republic of Germany
  2. 2.Department of Pharmacology, Eve Topf and National Parkinson’s Foundation Centers for Neurodegenerative DiseasesBruce Rappaport Family Research Institute, Faculty of MedicineTechnionIsrael

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