Tremorlytic activity of budipine in Parkinson’s disease
In order to objectively quantify the tremorlytic activity of budipine in Parkinson’s disease (PD) we performed longterm tremor recordings in a subset of patients enrolled in two clinical trials.
Eleven PD patients with marked tremor participating in an open-label study underwent longterm recording before and during medication. Nine patients completed the study. Tremor occurrence was reduced from 52 ± 18.6% to 34.7 ± 19.3% (p < 0.05); tremor intensity decreased from 15.3 ± 4.8 (SNR)to 11.3 ± 4.8 (p < 0.01). UPDRS tremor subscores were also significantly improved.
Fourteen patients who enrolled in a multicenter, double-blind, placebo-controlled study underwent longterm tremor analysis in addition to the Columbia University Rating Scale (CURS). Tremor occurrence was improved in the budipine group (n = 7) from 24.7 ± 15.5% to 14.8 ± 14.5% (p < 0.05). Tremor intensity decreased from 9.1 ± 2.5 (SNR) to 7.2 ± 1.6. However, the latter result was statistically not significant, probably due to the small patient number. In the placebo-group (n = 7) there was no reduction of tremor occurrence or of tremor intensity. The CURS sum score was improved from 5.7 to 3.0 in the budipine group, whereas there was only a smaller improvement in the placebo group (from 7.1 to 5.5).
These data suggest that budipine is an effective tremorlytic agent in PD, which may by used as an alternative to anticholinergics.
KeywordsPostural Tremor Levodopa Equivalance Dose Tremor Intensity Study Adverse Effect Tremor Recording
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- Duvoisin RC (1971) The evaluation of extrapyramidal disease. In: Ajuriaguerra J, Gauthier G (eds) Monoamines noyaux gris centraux et syndrome de Parkinson. Georg & Cie, Genf, pp 313–325Google Scholar
- Fahn S, Tolosa E, Marin C (1988) Clinical rating scale for tremor. In: Jankovic J, Tolosa E (eds) Parkinson’s disease and movement disorders. Urban & Schwarzenberg, Baltimore, pp 225–234Google Scholar