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Der plötzliche Asthmatod des Jugendlichen

  • Conference paper
Das therapieresistente Asthma
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Zusammenfassung

Der Asthmatod ist selten und bleibt noch immer in vielen Aspekten unverstanden. Klinisch kann bei tödlichen Erkrankungsexazerbationen zwischen dem langsam über Tage hinweg sich entwickelnden „Crescendotyp“ und dem plötzlichen asphyxierenden Asthma unterschieden werden. Für letztere Form des Asthmatodes weisen klinische, pathologisch-anatomische und pathophysiologische Beobachtungen darauf hin, daß massiver Bronchospasmus eine Schlüsselrolle innehat. Exzessiv gesteigerte bronchiale Reagibilität, reduzierte Chemorezeptorensensitivität auf Hypoxie sowie subjektive Unterperzeption der Luftwegsobstruktion scheinen als begünstigende Faktoren wirksam zu werden. Schlechte psychosoziale Verhältnisse und Adoleszenz sind Risikofaktoren auf seiten des Patienten; mangelhafte Dauertherapie, nicht ausreichend energische Akutversorgung und fehlende Erkennung des Risikopatienten werden auf seiten der Medizin risikosteigernd wirksam.

Summary

Fatal asthma is rare and remains an ill-understood entity. From a clinical perspective, one can distinguish between slowly developing fatal or near fatal exacerbations and sudden asphyxiating asthma. Some clinical, pathologic and pathophysiologic evidence suggests that sudden death from asthma might frequently be the consequence of excessive bronchoconstriction. Exaggerated bronchial hyperresponsiveness, reduced chemoreceptor sensitivity to hypoxia, and underperception of airflow obstruction seem to function as pathophysiologic cofactors. Psychosocial problems and adolescence are special patient-related risk factors, while faulty longterm asthma management, insufficient emergency treatment, and lacking identification of patients at risk seem to be medical shortcomings that facilitate a fatal outcome of bronchial asthma.

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Literatur

  1. Beasley CRW, Pearce NE, Crane J (1998) Worldwide trends in asthma mortality during the twentieth century. In: Sheffer AL (ed) Fatal asthma. New York, Marcel Dekker, pp 13–27

    Google Scholar 

  2. Woolcock AJ (1998) Natural history of fatal asthma. In: Sheffer AL (ed) Fatal asthma. New York, Marcel Dekker, pp 179–196

    Google Scholar 

  3. Fletcher HJ, Ibrahim SA, Speight N (1990) Survey of asthma deaths in the northern region, 1970–1985. Arch Dis Child 65: 1970–1985

    Article  PubMed  CAS  Google Scholar 

  4. Benatar SR (1986) Fatal asthma. N Engl J Med 314: 423–429

    Article  PubMed  CAS  Google Scholar 

  5. Roe PF (1965) Sudden death in asthma. Br J Dis Chest 59: 158–163

    Article  PubMed  CAS  Google Scholar 

  6. Stableforth D (1983) Death from asthma. Thorax 38: 801–805

    Article  PubMed  CAS  Google Scholar 

  7. Wasserfallen JB, Schaller MD, Feinl F, Perret CH (1990) Sudden asphyxic asthma: a distinct entity? Am Rev Respir Dis 142: 108–111

    PubMed  CAS  Google Scholar 

  8. Strunk RC (1993) Death due to asthma. New insights into sudden unexpected deaths, but the focus remains on prevention. Am Rev Respir Dis 148: 550–552

    Article  PubMed  CAS  Google Scholar 

  9. Mark EJ (1998) Pathology of fatal asthma. In: Sheffer AL (ed) Fatal asthma. New York, Marcel Dekker, pp 127–138

    Google Scholar 

  10. Ried LM (1987) The presence or absence of bronchial mucus in fatal asthma. J Allergy Clin Immunol 80: 415–416

    Article  Google Scholar 

  11. Synek M, Beasley R, Frew AJ, Goulding D, Holloway L, Lampe FC, Roche WR Holgate ST (1996) Cellular infiltration of the airways in asthma of varying severity. Am J Respir Crit Care Med 154: 224–230

    PubMed  CAS  Google Scholar 

  12. Sur S, Crotty TB, Kephart GM, Hyma BA, Colby TV, Reed CE, Hunt LW, Gleich GJ (1993) Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am Rev Respir Dis 148: 713–719

    Article  PubMed  CAS  Google Scholar 

  13. Carroll N, Carello S, Cooke C, James A (1996) Airway structure and inflammatory cells in fatal attacks of asthma. Eur Respir J 9: 709–715

    Article  PubMed  CAS  Google Scholar 

  14. Saetta M, DiStefano A, Rosina C, Thiene G, Fabbri LM (1991) Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 143: 138–143

    PubMed  CAS  Google Scholar 

  15. Bai TB (1990) Abnormalities in airway smooth muscle in fatal asthma. Am Rev Respir Dis 141: 552–557

    Article  PubMed  CAS  Google Scholar 

  16. Pouw EM, Koeter GH, deMonchy JGR, Homan AJ, Sluiter HJ (1990) Clinical assessment after a life-threatening attack of asthma: the role of bronchial hyperreactivity. Eur Respir J 3: 861–866

    PubMed  CAS  Google Scholar 

  17. Zach MS, Karner U (1989) Sudden death in asthma. Arch Dis Child 64: 1446–1451

    Article  PubMed  CAS  Google Scholar 

  18. Warner JO, Nikolaizik WH, Besley CR, Warner JA (1998) A childhood asthma death in a clinical trial: potential indicators of risk. Eur Respir J 11: 229–233

    Article  PubMed  CAS  Google Scholar 

  19. O’Hollaren MT, Yunginger JW, Offord KP, Somers MJ, O’Connell EJ, Ballard DJ, Sachs MJ (1991) Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med 324: 359–363

    Article  PubMed  Google Scholar 

  20. Nguyen MT, Patterson K, Sly RM (1985) Causes of death from asthma in children. Ann Allergy 55: 448–453

    PubMed  CAS  Google Scholar 

  21. Molfino NA, Nannini LJ, Martelli AN, Slutsky AS (1991) Respiratory arrest in near fatal asthma. N Engl J Med 324: 285–288

    Article  PubMed  CAS  Google Scholar 

  22. Rubinstein S, Hindi RD, Moss RB, Blessig-Moore J, Lewiston NJ (1984) Sudden death in adolescent asthma. Ann Allergy 53: 311–318

    PubMed  CAS  Google Scholar 

  23. Kikuchi Y, Okabe S, Tamura G, Hida W, Homma M, Shirato K, Takishima T (1994) Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma. N Engl J Med 330: 1329–34

    Article  PubMed  CAS  Google Scholar 

  24. Mellis CM, Phelan PD (1977) Asthma deaths in children ¡ª a continuing problem. Thorax 32: 29–34

    Article  PubMed  CAS  Google Scholar 

  25. Carswell F (1985) Thirty deaths from asthma. Arch Dis Child 60: 25–28

    Article  PubMed  CAS  Google Scholar 

  26. Lieu TA, Quesenberry CP, Sorel ME, Mendoza GR, Leong AB (1998) Computer-based models to identify high-risk children with asthma. Am J Respir Crit Care Med 157: 1173–1180

    PubMed  CAS  Google Scholar 

  27. McFadden ER (1991) Fatal and near-fatal asthma. N Engl J Med 324: 409–411

    Article  PubMed  Google Scholar 

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© 2000 Springer-Verlag Wien

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Zach, M. (2000). Der plötzliche Asthmatod des Jugendlichen. In: Kummer, F., Kneußl, M. (eds) Das therapieresistente Asthma. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6335-1_4

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  • DOI: https://doi.org/10.1007/978-3-7091-6335-1_4

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83401-5

  • Online ISBN: 978-3-7091-6335-1

  • eBook Packages: Springer Book Archive

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