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Prions: from neurografts to neuroinvasion

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Prion Diseases

Part of the book series: Archives of Virology. Supplementa ((ARCHIVES SUPPL,volume 16))

Summary

Spongiform encephalopathies are infectious neurodegenerative diseases caused by pathogens that seem to be devoid of any informational nucleic acids. Histopathologically, these diseases are characterized by spongiform degeneration of the central nervous system. Although the main pathological changes during the course of the disease occur in the brain, the infectious agent accumulates early in lymphoid tissue. The consecutive development of clinical disease depends on the presence of an intact immune system including mature B-cells and follicular dendritic cells. In this article we review the state of knowledge on the routes of neuroinvasion used by the infectious agent in order to gain access to the central nervous system upon entry into extracerebral sites.

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Author information

Authors and Affiliations

  1. Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland

    M. Glatzel, M. A. Klein, S. Brandner & A. Aguzzi

Authors
  1. M. Glatzel
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  2. M. A. Klein
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  3. S. Brandner
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  4. A. Aguzzi
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Editor information

Editors and Affiliations

  1. Institut für Immunologie, Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen, Germany

    Martin H. Groschup

  2. Institut für Neuropathologie, Ludwig-Maximilians-Universität, München, Germany

    Hans A. Kretzschmar

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© 2000 Springer-Verlag Wien

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Glatzel, M., Klein, M.A., Brandner, S., Aguzzi, A. (2000). Prions: from neurografts to neuroinvasion. In: Groschup, M.H., Kretzschmar, H.A. (eds) Prion Diseases. Archives of Virology. Supplementa, vol 16. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6308-5_1

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  • DOI: https://doi.org/10.1007/978-3-7091-6308-5_1

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83529-6

  • Online ISBN: 978-3-7091-6308-5

  • eBook Packages: Springer Book Archive

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