Monitoring neuroprotection and restorative therapies in Parkinson’s disease with PET

  • D. J. Brooks
Conference paper


In this article the role of functional imaging (PET and SPECT) as a surrogate marker for following the progression of Parkinson’s disease (PD) is discussed. The potential value of PET and SPECT for assessing the efficacy of putative neuroprotective agents in PD is considered and a review of 18F-dopa PET findings in transplantation trials involving implantation of human and procine fetal mesencephalic tissue is presented. It is concluded that functional imaging provides a valuable adjunct to clinical assessment when judging the efficacy of neuroprotective and restorative approaches to PD.


Positron Emission Tomography Multiple System Atrophy Restorative Therapy Dopa Positron Emission Tomography Nigral Cell Loss 
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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • D. J. Brooks
    • 1
  1. 1.MRC Clinical Sciences Centre, Imperial College School of MedicineHammersmith HospitalLondonUK

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