Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics

  • R. A. Floyd
  • K. Hensley
  • G. Bing
Conference paper


Our attempts to explain the serendipitous observations made on the neuroprotective action of a-phenyl-tert-butyl-nitrone (PBN) several years ago provided a challenge, which lead us to postulate the occurrence of neuroinflammatory processes in the stroked and the aging brain to help explain the results. Surprising observations made earlier by other investigators also forced them to conclude that enhanced neuro-inflammatory processes occur in the Alzheimer’s Disease (AD) brain. Observations we made recently, combined with the early seminal findings and the many others made since, overwhelmingly support the notion that neuro-inflammatory processes occur in the AD brain. Results obtained in our attempts to explain the mechanistic basis of the neuroprotective action of PBN provide strong support for the notion that this compound acts, not by trapping free radicals in a mass-action


Kainic Acid Signal Transduction Process Neuroinflammatory Process Gerbil Brain Kainic Acid Treatment 


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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • R. A. Floyd
    • 1
    • 2
  • K. Hensley
    • 2
  • G. Bing
    • 2
  1. 1.Free Radical Biology and Aging Research ProgramOklahoma Medical Research FoundationOklahoma CityUSA
  2. 2.Department of Biochemistry and Molecular BiologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA

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