Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment

  • N. Stefanova
  • K. Seppi
  • C. Scherfler
  • Z. Puschban
  • G. K. Wenning
Conference paper


Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) are increasingly recognized as alphasynucleinopathies, i.e. neurodegenerative disorders that share a common sub-cellular pathology characterized by alpha-synuclein abnormal aggregation. In the present review we focus on depression in alpha-synucleinopathies, discussing epidemiological, pathophysiological and treatment aspects of this frequently disabling clinical feature which may occur in PD, DLB and MSA alike.


Multiple System Atrophy Locus Coeruleus Dementia With Lewy Body Dorsal Raphe Nucleus Multiple System Atrophy Patient 
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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • N. Stefanova
    • 1
    • 2
  • K. Seppi
    • 1
  • C. Scherfler
    • 1
  • Z. Puschban
    • 1
  • G. K. Wenning
    • 1
  1. 1.Department of NeurologyUniversity HospitalInnsbruckAustria
  2. 2.Department of Anatomy and HistologyMedical UniversitySofiaBulgaria

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