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GDF-15/MIC-1 a novel member of the TGF-ß superfamily

  • J. Strelau
  • M. Böttner
  • P. Lingor
  • C. Suter-Crazzolara
  • D. Galter
  • J. Jaszai
  • A. Sullivan
  • A. Schober
  • K. Krieglstein
  • K. Unsicker
Conference paper

Summary

We have cloned, expressed, and raised antibodies against a novel member of the TGF-ß superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-ß superfamily and does not belong to one of the known TGF-(3 subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.

Keywords

Culture Dorsal Root Ganglion Distant Member Putative Translation Start Transform Growth Factor Beta Superfamily Macrophage Inhibitory Cytokine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • J. Strelau
    • 1
  • M. Böttner
    • 1
  • P. Lingor
    • 1
  • C. Suter-Crazzolara
    • 2
  • D. Galter
    • 1
  • J. Jaszai
    • 1
  • A. Sullivan
    • 3
  • A. Schober
    • 4
  • K. Krieglstein
    • 4
  • K. Unsicker
    • 1
  1. 1.Neuroanatomy and Center for NeuroscienceUniversity of HeidelbergHeidelbergFederal Republic of Germany
  2. 2.Department of Molecular BiophysicsGerman Cancer Research Center (DKFZ)HeidelbergFederal Republic of Germany
  3. 3.Department of AnatomyUniversity CollegeCorkIreland
  4. 4.Department of AnatomyUniversity of the SaarlandHomburgFederal Republic of Germany

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