GDF-15/MIC-1 a novel member of the TGF-ß superfamily
We have cloned, expressed, and raised antibodies against a novel member of the TGF-ß superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-ß superfamily and does not belong to one of the known TGF-(3 subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.
KeywordsCulture Dorsal Root Ganglion Distant Member Putative Translation Start Transform Growth Factor Beta Superfamily Macrophage Inhibitory Cytokine
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