Homocysteine and alcoholism

  • S. Bleich
  • D. Degner
  • K. Javaheripour
  • C. Kurth
  • J. Kornhuber
Conference paper


Chronic alcohol consumption can induce alterations in the function and morphology of most if not all brain systems and structures. However, the exact mechanism of brain damage in alcoholics remains unknown. Partial recovery of brain function with abstinence suggests that a proportion of the deficits must be functional in origin (i.e. plastic changes of nerve cells) while neuronal loss from selected brain regions indicates permanent and irreversible damage. There is rowing evidence that chronic alcoholism is associated with a derangement in the sulfur amino acid metabolism. Recently, it has been shown that excitatory amino acid (EAA) neurotransmitters and homocysteine levels are elevated in patients who underwent withdrawal from alcohol. Furthermore, it has been found that homocysteine induces neuronal cell damage by timulating NMDA receptors as well as by producing free radicals. Homocysteine neurotoxicity via overstimulation of N- ethyl-D-aspartate receptors may contribute to the pathogenesis of both brain shrinkage and withdrawal seizures linked to alcoholism.


NMDA Receptor Excitatory Amino Acid Alcohol Withdrawal Fatty Acid Ethyl Ester Excitatory Amino Acid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • S. Bleich
    • 1
  • D. Degner
    • 1
  • K. Javaheripour
    • 2
  • C. Kurth
    • 1
  • J. Kornhuber
    • 1
  1. 1.Department of PsychiatryGeorg-August-University of GöttingenGöttingenFederal Republic of Germany
  2. 2.Department of NeuroradiologyGeorg-August-University of GöttingenGöttingenFederal Republic of Germany

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