Advertisement

Yt System

  • Helmut Schenkel-Brunner

Abstract

The Yt blood group system(1) includes two antithetical antigens, Yt a [4] and Yt b [6](2) with the respective gene-frequencies of 0.96 and 0.04 [8].

Keywords

Blood Group Human Erythrocyte Paroxysmal Nocturnal Haemoglobinuria Blood Group Antigen Erythrocyte Membrane Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bartels, C. F., Zelinski, T. & Lockridge, O. (1993): Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism. Amer. J. Hum. Genet. 52, 928–936.PubMedGoogle Scholar
  2. 2.
    Branch, D. R., Muensch, H. A., Sy Siok Han, A. L. & Petz, L. D. (1983): Disulfide bonds are a requirement for Kell and Cartwright (YP) blood group antigen integrity. Brit. J. Haematol. 54, 573–578.CrossRefGoogle Scholar
  3. 3.
    Daniels, G. (1992): Effect of enzymes on and chemical modifications of high-frequency red cells antigens. Immunohaematology 8, 53–57.Google Scholar
  4. 4.
    Eaton, B. R., Morton, J. A., Pickles, M. M. & White, K. E. (1956): A new antibody, anti-Yta, characterising a blood group antigen of high incidence. Brit. J. Haematol. 2, 333–335.CrossRefGoogle Scholar
  5. 5.
    Getman, D. K., Eubanks, J. H., Camp, S., Evans, G. A. & Taylor, P. (1992): The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7. Amer. J. Hum. Genet. 51, 170–177.PubMedGoogle Scholar
  6. 6.
    Giles, C. M. & Metaxas, M. N. (1964): Identification of the predicted blood group antibody anti-Ytb. Nature 202, 1122–1123.PubMedCrossRefGoogle Scholar
  7. 7.
    Ott, P. (1985): Membrane acetylcholinesterases: purification, molecular properties, and interactions with amphiphilic environments. Biochim. Biophys. Acta 822, 375–392.PubMedCrossRefGoogle Scholar
  8. 8.
    Race, R. R. & Sanger, R. (1975): The Yt blood groups. In: Blood Groups in Man. Blackwell Scientific Publications, Oxford, pp. 379–382.Google Scholar
  9. 9.
    Rao, N., Whitsett, C. F., Oxendine, S. M. & Telen, M. J. (1993): Human erythrocyte acetylcholinesterase bears the Yta blood group antigen and is reduced or absent in the Yt(a-b-) phenotype. Blood 81, 815–819.PubMedGoogle Scholar
  10. 10.
    Shulman, I. A., Nelson, J. M. & Lam, H. T. (1986): Loss of Ytb antigen activity after treatment of red cells with either dithiothreitol or 2-mercaptoethanol. Transfusion 26, 214.PubMedCrossRefGoogle Scholar
  11. 11.
    Spring, F. A., Gardner, B. & Anstee, D. J. (1992): Evidence that the antigens of the Yt blood group system are located on human erythrocyte acetylcholinesterase. Blood 80, 2136–2141.PubMedGoogle Scholar
  12. 12.
    Telen, M. J., Rosse, W. F., Parker, C. J., Moulds, M. K. & Moulds, J. J. (1990): Evidence that several high-frequency human blood group antigens reside on phosphatidylinositol-linked erythrocyte membrane proteins. Blood 75, 1404–1407.PubMedGoogle Scholar
  13. 13.
    Telen, M. J. & Whitsett, C. F. (1992): Erythrocyte acetylcholinesterase bears the Cartwright blood group antigens. Clin. Res. 40, 170A.Google Scholar
  14. 14.
    Zelinski, T., White, L., Coghlan, G. & Philipps, S. (1991): Assigment of the YT blood group locus to chromosome 7q. Genomics 11, 165–167.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für Medizinische BiochemieUniversität WienViennaAustria

Personalised recommendations