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Dombrock System

  • Helmut Schenkel-Brunner

Abstract

The Dombrock blood group system originally comprised two antithetical antigens, Do a [11] and Dob [5]. More recent reports, however, showed that the Dombrock characters and the antigens Jo a (Joseph) [4], Hy (Holley) [7], and Gy a (Gregory) [10] are phenotypically closely related [6,13] for the following reasons:
  • all these antigens are absent on Gy(a-) cells, suggesting that Gy(a-) is the null phenotype for these blood group characters. Lack of Dombrock, Joseph, or Holley antigens has a varying but nonetheless significant influence on the expression of the other antigens;

  • the characters Do a, Hy, and Gy a are destroyed in situ by pronase and trypsin, and to a lesser extent by α-chymotrypsin [9]; they are resistant, however, to digestion by papain. Further, the antigens are sensitive to treatment with reducing agents;

  • biochemical studies have provided evidence that all these characters reside on the same erythrocyte membrane glycoprotein [1,2,9].

Keywords

Blood Group Erythrocyte Membrane Paroxysmal Nocturnal Haemoglobinuria Antigenic Determinant Working Party 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für Medizinische BiochemieUniversität WienViennaAustria

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