Dombrock System

  • Helmut Schenkel-Brunner


The Dombrock blood group system originally comprised two antithetical antigens, Do a [11] and Dob [5]. More recent reports, however, showed that the Dombrock characters and the antigens Jo a (Joseph) [4], Hy (Holley) [7], and Gy a (Gregory) [10] are phenotypically closely related [6,13] for the following reasons:
  • all these antigens are absent on Gy(a-) cells, suggesting that Gy(a-) is the null phenotype for these blood group characters. Lack of Dombrock, Joseph, or Holley antigens has a varying but nonetheless significant influence on the expression of the other antigens;

  • the characters Do a, Hy, and Gy a are destroyed in situ by pronase and trypsin, and to a lesser extent by α-chymotrypsin [9]; they are resistant, however, to digestion by papain. Further, the antigens are sensitive to treatment with reducing agents;

  • biochemical studies have provided evidence that all these characters reside on the same erythrocyte membrane glycoprotein [1,2,9].


Blood Group Erythrocyte Membrane Paroxysmal Nocturnal Haemoglobinuria Antigenic Determinant Working Party 
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  1. 1.
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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für Medizinische BiochemieUniversität WienViennaAustria

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