Duffy System

  • Helmut Schenkel-Brunner


Duffy is a polymorphic blood group system of which six characters are defined to date (Table 16.1) (1):
  • the two principal antigens, Fya (= FY1) [16,17] and Fyb (= FY2) [26]. Based on the presence or absence of these antigens four phenotypes have been defined — Fy(a+b-), Fy(a-b+), Fy(a+b+) (with frequencies in Europids of 0.195, 0.33, and 0.475, respectively), and Fy(a-b-). This last phenotype is the predominant phenotype in Negrids but exceedingly rare outside the black population;

  • the characters Fy3 (= FY3) [2], Fy5 (= FY5) [14], and Fy6 (= FY6) [45,51], being linked to the expression of Fya and Fyb antigens, are present on the red cells of all persons except those of the Fy(a-b-) phenotype. These antigens thus represent epitopes localised on discrete domains of the Duffy blood group substance;

  • Fy4 (= FY4) [4] is present on almost all samples of Fy(a-b-) erythrocytes and some Fy(a+b-) and Fy(a-b+) cells from Negrids; the status of this antigenic character within the Duffy system is not yet clear.


Blood Group Blood Group Antigen Plasmodium Knowlesi Blood Group System Human Blood Group 
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© Springer-Verlag Wien 2000

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für Medizinische BiochemieUniversität WienViennaAustria

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