In 1940 Landsteiner and Wiener  immunized rabbits and guinea pigs with the red cells of rhesus monkeys. The immune sera (’anti-Rh’) obtained by this stimulus reacted with 85% of adult human blood samples. At that time the ’Rhesus’ antigen has been considered the animal equivalent of the human antigen responsible for erythroblastosis foetalis (HDN), because the frequency of reactivity of rabbit sera with human erythrocytes matched that of a human antibody. This antibody had been obtained from a woman who had delivered a stillborn fetus which had died in utero of HDN . Later investigations, however, proved conclusively that the human and animal antibodies described two different specificities (cf. ), and the ’Rh’ antigen was subsequently renamed LW in honor of Landsteiner and Wiener.
KeywordsBlood Group Immune Seron Human Erythrocyte Membrane Congenital Dyserythropoietic Anemia Stillborn Fetus
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