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Rh System

  • Helmut Schenkel-Brunner

Abstract

In 1939, Levine and Stetson [160] first assumed that serological incompatibility between mother and child was the cause of erythroblastosis fetalis, also known as haemolytic disease of the newborn (HDN). The authors found that a maternal antibody entering the foetal circulation led to destruction of fetal erythrocytes. One year later, Wiener and Peters [277] were able to identify the same antibody in the serum of individuals showing transfusion reactions after ABO-compatible blood transfusions. In 1941, Levine et al. [156] reported that the antibody responsible for this disease had the same specificity as the anti-Rhesus antibody obtained by Landsteiner and Wiener [147,148] after injecting rabbits and guinea pigs with erythrocytes of rhesus monkeys.

Keywords

Blood Group Erythrocyte Membrane Blood Group Antigen Blood Group System Molecular Biological Investigation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Wien 2000

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für Medizinische BiochemieUniversität WienViennaAustria

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