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Human Blood Groups pp 398–408Cite as

Sialic Acid-Containing Receptors for Cold Agglutinins

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Abstract

Various cold agglutinins which react with sialic acid-dependent antigens of the red cell membrane have been described in human sera. Seven specificities have been defined to date: Pr [49], Gd (Sia-lb1) [48], Sa [47], FI (Sia-b1) [30], Lud [31], Vo (Sia- l1) [46], and Li [34].

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References

  1. Anstee, D. J. (1980): Blood group MNSs-active sialogiycoproteins of the human erythrocyte membrane. In: Immunobiobgy of the Erythrocyte (S.G. Sandler, J. Nusbacher, and M. S. Schanfield, eds.). Alan R. Liss Inc., New York, pp. 67–98.

    Google Scholar 

  2. Anstee, D. J. & Edwards, P. A. W. (1982): Monoclonal antibodies to human erythrocytes. Eur. J. Immunol. 12, 228–232.

    Article  PubMed  CAS  Google Scholar 

  3. Dahr, W., Lichthardt, D. & Roelcke, D. (1981): Studies on the receptor sites of the monoclonal anti-Pr and-Sa cold agglutinins. Protides Biol. Fluids 29, 365–368.

    Google Scholar 

  4. Dellagi, K., Brouet, J. C., Schenmetzler, C. & Praloran, V. (1981): Chronic hemolytic anemia due to a monoclonal IgG cold agglutinin with anti-Pr specificity. Blood 57, 189–191.

    PubMed  CAS  Google Scholar 

  5. Ebert, W., Fey, J., Gärtner, C., Geisen, H. P., Rautenberg, U., Roelcke, D. & Weicker, H. (1979): Isolation and partial characterization of the Pr autoantigen determinants. Molec. Immunol. 16, 413–419.

    Article  CAS  Google Scholar 

  6. Ebert, W., Metz, J. & Roelcke, D. (1972): Modifications of N-acetylneuraminic acid and their influence on the antigen activity of erythrocyte glycoproteins. Eur. J. Biochem. 27, 470–472.

    Article  PubMed  CAS  Google Scholar 

  7. Gallart, T., Roelcke, D., Blay, M., Pereira, A., Martinez, A., Massö, O., Vinas, O., Cid, M., Esparza, J., Molina, R. & Barceló, J. (1997): Anti-Sia-lb (anti-Gd) cold agglutinins bind the domain NeuNAcα2-3Gal in sialyl Lewisx, sialyl Lewisa, and related carbohydrates on nucleated cells and in soluble cancer-associated mucins. Blood 90, 1576–1587.

    PubMed  CAS  Google Scholar 

  8. Garratty, G., Petz, L. D., Brodsky, I. & Fudenberg, H. H. (1973): An IgA high-titer cold agglutinin with an unusual blood group specificity within the Pr complex. Vox Sang. 25, 32–38.

    Article  PubMed  CAS  Google Scholar 

  9. Geisen, H. P., Roelcke, D., Rhen, K. & Konrad, G. (1975): Hochtitrige Kälteagglutinine der Spezifität Anti-Pr nach Rötelinfektion. Klin. Wschr. 53, 767–772.

    Article  PubMed  CAS  Google Scholar 

  10. Göttsche, B., Salama, A. & Mueller-Eckhardt, C. (1990): Autoimmune hemolytic anemia caused by a cold agglutinin with a new specificity (anti-Ju). Transfus. 30, 261–262.

    Article  Google Scholar 

  11. Hengge, U. R., Kirschfink, M., König, A. L., Nicklas, W. & Roelcke, D. (1992): Characterization of I/FI glycoprotein as a receptor for Mycoplasma pneumoniae. Infect. Immun. 60, 79–83.

    PubMed  CAS  Google Scholar 

  12. Herron, B., Roelcke, D., Orson, G., Myint, H. & Boulton, F. E. (1993): Cold autoagglutinins with anti-Pr specificity associated with fresh Varicella infection. Vox Sang. 65, 239–242.

    Article  PubMed  CAS  Google Scholar 

  13. Hoare, D. G. & Koshland, D. E. (1967): A method for the quantitative modification and estimation of carboxylic acid groups in proteins. J. Biol. Chem. 242, 2447–2453.

    PubMed  CAS  Google Scholar 

  14. Kajii, E. & Ikemoto, S. (1989): A cold agglutinin: Om. Vox Sang. 56, 104–106.

    Article  PubMed  CAS  Google Scholar 

  15. Kajii, E., Ikemoto, S. & Miura, Y. (1988): Localization of the Lud antigen by immunoblotting. Vox Sang. 54, 248.

    Article  PubMed  CAS  Google Scholar 

  16. Kannagi, R., Roelcke, D., Peterson, K. A., Okada, Y., Levery, S. B. & Hakomori, S. I. (1983): Characterization of epitope (determinant) structure in a developmentally regulated glycolipid antigen defined by a cold agglutinin Fl, Recognition of α-sialosyl and α-L-fucosyl groups in a branched structure. Carbohydr. Res. 120, 143–157.

    Article  PubMed  CAS  Google Scholar 

  17. Kewitz, S., Grob, H. J., Kosa, R. & Roelcke, D. (1995): Anti-Pr cold agglutinins recognize immunodominant α2,3-or α2,6-sialyl groups on glycophorins. Glycocon. J. 12, 714–720.

    Article  CAS  Google Scholar 

  18. König, A. L., Kather, H. & Roelcke, D. (1984): Autoimmune hemolytic anemia by coexisting anti-l and anti-FI cold agglutinins. Blut 49, 363–368.

    Article  PubMed  Google Scholar 

  19. König, A. L., Keller, H. E., Braun, R. W. & Roelcke, D. (1992): Cold agglutinins of anti-Pr specificity in Rubella embryopathy. Ann. Hematol. 64, 277–280.

    Article  PubMed  Google Scholar 

  20. König, A. L., Kreft, H., Hengge, U., Braun, R. W. & Roelcke, D. (1988): Coexisting anti-l and anti-Fl/Gd cold agglutinins in infections by Mycoplasma pneumoniae. Vox Sang. 55, 176–180.

    Article  PubMed  Google Scholar 

  21. Kundu, S. K., Marcus, D. M. & Roelcke, D. (1982): Glycosphingolipid receptors for anti-Gd and anti-p cold agglutinins. Immunol. Lett. 4, 263–267.

    Article  PubMed  CAS  Google Scholar 

  22. Lenhard, V., Seelig, H. P., Geisen, H. P. & Roelcke, D. (1978): Identification of I, i, Pr1-3 and Gd antigens in the human kidney: possible relevance to hyperacute graft rejection induced by cold agglutinins. Clin. Exp. Immunol. 33, 276–282.

    PubMed  CAS  Google Scholar 

  23. Lisowska, E. & Roelcke, D. (1973): Differentiation of anti-Pr1, and anti-Pr2 — sera with periodate-oxidized erythrocyte glycoproteins. Blut 26, 339–341.

    Article  PubMed  CAS  Google Scholar 

  24. Marsh, W. L. & Jenkins, W. J. (1968): Anti-Sp,: the recognition of a new cold auto-antibody. Vox Sang. 15, 177–186.

    Article  PubMed  CAS  Google Scholar 

  25. Pruzanski, W., Armstrong, M. & Roelcke, D. (1981): New antigenic determinant (Sa) on human lymphocytes and phagocytes. Blut 43, 307–313.

    Article  PubMed  CAS  Google Scholar 

  26. Pruzanski, W., Roelcke, D., Armstrong, M. & Manly, M. S. (1980): Pr and Gd antigens on human B and T lymphocytes and phagocytes. Clin. Immunol. Immunopathol. 15, 631–641.

    Article  PubMed  CAS  Google Scholar 

  27. Roelcke, D. (1969): A new serological specificity in cold antibodies of high titre: anti-HD. Vox Sang. 16, 76–79.

    Article  PubMed  CAS  Google Scholar 

  28. Roelcke, D. (1973): Serological studies on the Pr1/Pr2 antigens using dog erythrocytes. Differentiation of Pr2 from Pr1 and detection of a Pr1 heterogeneity: Pr1h / Pr1d. Vox Sang. 24, 354–361.

    Article  PubMed  CAS  Google Scholar 

  29. Roelcke, D. (1973): Specificity of IgA cold agglutinins: anti-Pr1. Eur. J. Immunol. 3, 206–212.

    Article  PubMed  CAS  Google Scholar 

  30. Roelcke, D. (1981): A further cold agglutinin, Fl, recognizing a N-acetylneuraminic acid-determined antigen. Vox Sang. 41, 98–101.

    Article  PubMed  CAS  Google Scholar 

  31. Roelcke, D. (1981): The Lud cold agglutinin: a further antibody recognizing N-acetylneuraminic acid-determined antigens not fully expressed at birth. Vox Sang. 41, 316–318.

    Article  PubMed  CAS  Google Scholar 

  32. Roelcke, D. (1981): Pr and Gd antigens. Blood Transfus. Immunohaematol. 24, 27–36.

    Article  CAS  Google Scholar 

  33. Roelcke, D. (1984): Reaction of anti-Gd, anti-FI, and anti-Sa cold agglutinins with p erythrocytes. Vox Sang. 46, 161–164.

    Article  PubMed  CAS  Google Scholar 

  34. Roelcke, D. (1985): Li cold agglutinin: a further antibody recognizing sialic acid-dependent antigens fully expressed on newborn erythrocytes. Vox Sang. 48, 181–183.

    Article  PubMed  CAS  Google Scholar 

  35. Roelcke, D., Anstee, D. J., Jungfer, H., Nutzenadel, W. & Webb, A. J. (1971): IgG-type cold agglutinins in children and corresponding antigens. Detection of a new Pr antigen: Pra. Vox Sang. 20, 218–229.

    Article  PubMed  CAS  Google Scholar 

  36. Roelcke, D. & Brossmer, R. (1984): Different fine specificities of human monoclonal anti-Gd cold agglutinins. Protides Biol. Fluids 31, 1075–1082.

    Google Scholar 

  37. Roelcke, D., Brossmer, R. & Ebert, W. (1982): Anti-P1,-Gd, and related cold agglutinins: human monoclonal antibodies against neuraminyl groups. Protides Biol. Fluids 29, 619–622.

    Google Scholar 

  38. Roelcke, D., Dahr, W. & Kalden, J. R. (1986): A human monoclonal IgMk cold agglutinin recognizing oligosaccharides with immunodominant sialyl groups preferentially at the blood group M-specific peptide backbone of glycophorins: anti-Prm. Vox Sang. 51, 207–211.

    Article  PubMed  CAS  Google Scholar 

  39. Roelcke, D., Ebert, W. & Geisen, H. P. (1976): Anti-Pr3: serological and immunochemical identification of a new anti-Pr subspecificity. Vox Sang. 30, 122–133.

    Article  PubMed  CAS  Google Scholar 

  40. Roelcke, D., Ebert, W., Metz, J. & Weicker, H. (1971): I-, MN-, and Pr1/Pr2-activity of human erythrocyte glycoprotein fractions obtained by ficin treatment. Vox Sang. 21, 352–361.

    Article  PubMed  CAS  Google Scholar 

  41. Roelcke, D., Hack, H., Kreft, H. & Gross, H. J. (1998): α2,3-specific desialylation of human red cells: effect on the autoantigens of the Pr, Sa and Sia-l1,-b1,-Ib1 series. Vox Sang. 74, 109–112.

    Article  PubMed  CAS  Google Scholar 

  42. Roelcke, D., Hack, H., Kreft, H., Macdonald, B., Pereira, A. & Habibi, B. (1993): IgA cold agglutinins recognize Pr and Sa antigens expressed on glycophorins. Transfus. 33, 472–475.

    Article  CAS  Google Scholar 

  43. Roelcke, D., Hengge, U. & Kirschfink, M. (1990): Neolacto (type-2 chain) sialoautoantigens recognized by human cold agglutinins. Vox Sang. 59, 235–239.

    Article  PubMed  CAS  Google Scholar 

  44. Roelcke, D. & Kreft, H. (1984): Characterization of various anti-Pr cold agglutinins. Transfus. 24, 210–213.

    Article  CAS  Google Scholar 

  45. Roelcke, D., Kreft, H., Northoff, H. & Gallasch, E. (1991): Sia-b1 and I antigens recognized by Mycoplasma pneumoniae-induced cold agglutinins. Transfus. 31, 627–631.

    Article  CAS  Google Scholar 

  46. Roelcke, D., Kreft, H. & Pfister, A. M. (1984): Cold agglutinin Vo. An IgMA. monoclonal human antibody recognizing a sialic acid determined antigen fully expressed on newborn erythrocytes. Vox Sang. 47, 236–241.

    Article  PubMed  CAS  Google Scholar 

  47. Roelcke, D., Pruzanski, W., Ebert, W., Römer, W., Fischer, E., Lenhard, V. & Rauterberg, E. (1980): A new human monoclonal cold agglutinin Sa recognizing terminal N-acetylneuraminyl groups on the cell surface. Blood 55, 677–681.

    PubMed  CAS  Google Scholar 

  48. Roelcke, D., Riesen, W., Geisen, H. P. & Ebert, W. (1977): Serological identification of the new cold agglutinin specificity anti-Gd. Vox Sang. 33, 304–306.

    Article  PubMed  CAS  Google Scholar 

  49. Roelcke, D. & Uhlenbruck, G. (1970): Letter to the editor. Vox Sang. 18, 478–479.

    Article  PubMed  CAS  Google Scholar 

  50. Roelcke, D. & Weber, M. T. (1984): Simultaneous occurrence of anti-FI and anti-l cold agglutinins in a patient’s serum. Vox Sang. 47, 122–124.

    Article  PubMed  CAS  Google Scholar 

  51. Römer, W., Seelig, H. P., Lenhard, V. & Roelcke, D. (1979): The distribution of l/i, Pr, and Gd antigens in mammalian tissues. Invest. Cell Pathol. 2, 157–165.

    PubMed  Google Scholar 

  52. Salama, A., Pralle, H. & Mueller-Eckhardt, C. (1985): A new red blood cell cold autoantibody (anti-Me). Vox Sang. 49, 277–284.

    Article  PubMed  CAS  Google Scholar 

  53. Schwarting, G. A., Marcus, D. M. & Metaxas, M. (1977): Identification of sialosylparagloboside as an erythrocyte receptor for an ‘anti-p’ antibody. Vox Sang. 32, 257–261.

    Article  PubMed  CAS  Google Scholar 

  54. Suttajit, M. & Winzler, R. J. (1971): Effect of modification of N-acetylneuraminic acid on the binding of glycoproteins to influenza virus and on susceptibility to cleavage by neuraminidase. J. Biol. Chem. 246, 3398–3404.

    PubMed  CAS  Google Scholar 

  55. Tonthat, H., Rochant, H., Henry, A., Leporrier, M. & Dreyfus, B. (1976): A new case of monoclonal IgA kappa cold agglutinin with anti-Pr1d specificity in a patient with persistent HB antigen cirrosis. Vox Sang. 30, 464–468.

    Article  PubMed  CAS  Google Scholar 

  56. Uemura, K. I., Roelcke, D., Nagai, Y. & Feizi, T. (1984): The reactivities of human erythrocyte autoantibodies anti-Pr2, anti-Gd, Fl, and Sa with gangliosides in a chromatogram binding assay. Biochem. J. 219, 865–874.

    PubMed  CAS  Google Scholar 

  57. Watanabe, K., Powell, M. & Hakomori, S. I. (1978): Isolation and characterization of a novel fucoganglioside of human erythrocyte membranes. J. Biol. Chem. 253, 8962–8967.

    PubMed  CAS  Google Scholar 

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  1. Institut für Medizinische Biochemie, Universität Wien, Vienna, Austria

    Dr. Helmut Schenkel-Brunner

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© 2000 Springer-Verlag Wien

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Schenkel-Brunner, H. (2000). Sialic Acid-Containing Receptors for Cold Agglutinins. In: Human Blood Groups. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6294-1_12

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  • DOI: https://doi.org/10.1007/978-3-7091-6294-1_12

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7244-5

  • Online ISBN: 978-3-7091-6294-1

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