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Sialic Acid-Containing Receptors for Cold Agglutinins

  • Helmut Schenkel-Brunner

Abstract

Various cold agglutinins which react with sialic acid-dependent antigens of the red cell membrane have been described in human sera. Seven specificities have been defined to date: Pr [49], Gd (Sia-lb1) [48], Sa [47], FI (Sia-b1) [30], Lud [31], Vo (Sia- l1) [46], and Li [34].

Keywords

Sialic Acid Erythrocyte Membrane Mycoplasma Pneumoniae Autoimmune Hemolytic Anemia Oligosaccharide Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Anstee, D. J. (1980): Blood group MNSs-active sialogiycoproteins of the human erythrocyte membrane. In: Immunobiobgy of the Erythrocyte (S.G. Sandler, J. Nusbacher, and M. S. Schanfield, eds.). Alan R. Liss Inc., New York, pp. 67–98.Google Scholar
  2. 2.
    Anstee, D. J. & Edwards, P. A. W. (1982): Monoclonal antibodies to human erythrocytes. Eur. J. Immunol. 12, 228–232.PubMedCrossRefGoogle Scholar
  3. 3.
    Dahr, W., Lichthardt, D. & Roelcke, D. (1981): Studies on the receptor sites of the monoclonal anti-Pr and-Sa cold agglutinins. Protides Biol. Fluids 29, 365–368.Google Scholar
  4. 4.
    Dellagi, K., Brouet, J. C., Schenmetzler, C. & Praloran, V. (1981): Chronic hemolytic anemia due to a monoclonal IgG cold agglutinin with anti-Pr specificity. Blood 57, 189–191.PubMedGoogle Scholar
  5. 5.
    Ebert, W., Fey, J., Gärtner, C., Geisen, H. P., Rautenberg, U., Roelcke, D. & Weicker, H. (1979): Isolation and partial characterization of the Pr autoantigen determinants. Molec. Immunol. 16, 413–419.CrossRefGoogle Scholar
  6. 6.
    Ebert, W., Metz, J. & Roelcke, D. (1972): Modifications of N-acetylneuraminic acid and their influence on the antigen activity of erythrocyte glycoproteins. Eur. J. Biochem. 27, 470–472.PubMedCrossRefGoogle Scholar
  7. 7.
    Gallart, T., Roelcke, D., Blay, M., Pereira, A., Martinez, A., Massö, O., Vinas, O., Cid, M., Esparza, J., Molina, R. & Barceló, J. (1997): Anti-Sia-lb (anti-Gd) cold agglutinins bind the domain NeuNAcα2-3Gal in sialyl Lewisx, sialyl Lewisa, and related carbohydrates on nucleated cells and in soluble cancer-associated mucins. Blood 90, 1576–1587.PubMedGoogle Scholar
  8. 8.
    Garratty, G., Petz, L. D., Brodsky, I. & Fudenberg, H. H. (1973): An IgA high-titer cold agglutinin with an unusual blood group specificity within the Pr complex. Vox Sang. 25, 32–38.PubMedCrossRefGoogle Scholar
  9. 9.
    Geisen, H. P., Roelcke, D., Rhen, K. & Konrad, G. (1975): Hochtitrige Kälteagglutinine der Spezifität Anti-Pr nach Rötelinfektion. Klin. Wschr. 53, 767–772.PubMedCrossRefGoogle Scholar
  10. 10.
    Göttsche, B., Salama, A. & Mueller-Eckhardt, C. (1990): Autoimmune hemolytic anemia caused by a cold agglutinin with a new specificity (anti-Ju). Transfus. 30, 261–262.CrossRefGoogle Scholar
  11. 11.
    Hengge, U. R., Kirschfink, M., König, A. L., Nicklas, W. & Roelcke, D. (1992): Characterization of I/FI glycoprotein as a receptor for Mycoplasma pneumoniae. Infect. Immun. 60, 79–83.PubMedGoogle Scholar
  12. 12.
    Herron, B., Roelcke, D., Orson, G., Myint, H. & Boulton, F. E. (1993): Cold autoagglutinins with anti-Pr specificity associated with fresh Varicella infection. Vox Sang. 65, 239–242.PubMedCrossRefGoogle Scholar
  13. 13.
    Hoare, D. G. & Koshland, D. E. (1967): A method for the quantitative modification and estimation of carboxylic acid groups in proteins. J. Biol. Chem. 242, 2447–2453.PubMedGoogle Scholar
  14. 14.
    Kajii, E. & Ikemoto, S. (1989): A cold agglutinin: Om. Vox Sang. 56, 104–106.PubMedCrossRefGoogle Scholar
  15. 15.
    Kajii, E., Ikemoto, S. & Miura, Y. (1988): Localization of the Lud antigen by immunoblotting. Vox Sang. 54, 248.PubMedCrossRefGoogle Scholar
  16. 16.
    Kannagi, R., Roelcke, D., Peterson, K. A., Okada, Y., Levery, S. B. & Hakomori, S. I. (1983): Characterization of epitope (determinant) structure in a developmentally regulated glycolipid antigen defined by a cold agglutinin Fl, Recognition of α-sialosyl and α-L-fucosyl groups in a branched structure. Carbohydr. Res. 120, 143–157.PubMedCrossRefGoogle Scholar
  17. 17.
    Kewitz, S., Grob, H. J., Kosa, R. & Roelcke, D. (1995): Anti-Pr cold agglutinins recognize immunodominant α2,3-or α2,6-sialyl groups on glycophorins. Glycocon. J. 12, 714–720.CrossRefGoogle Scholar
  18. 18.
    König, A. L., Kather, H. & Roelcke, D. (1984): Autoimmune hemolytic anemia by coexisting anti-l and anti-FI cold agglutinins. Blut 49, 363–368.PubMedCrossRefGoogle Scholar
  19. 19.
    König, A. L., Keller, H. E., Braun, R. W. & Roelcke, D. (1992): Cold agglutinins of anti-Pr specificity in Rubella embryopathy. Ann. Hematol. 64, 277–280.PubMedCrossRefGoogle Scholar
  20. 20.
    König, A. L., Kreft, H., Hengge, U., Braun, R. W. & Roelcke, D. (1988): Coexisting anti-l and anti-Fl/Gd cold agglutinins in infections by Mycoplasma pneumoniae. Vox Sang. 55, 176–180.PubMedCrossRefGoogle Scholar
  21. 21.
    Kundu, S. K., Marcus, D. M. & Roelcke, D. (1982): Glycosphingolipid receptors for anti-Gd and anti-p cold agglutinins. Immunol. Lett. 4, 263–267.PubMedCrossRefGoogle Scholar
  22. 22.
    Lenhard, V., Seelig, H. P., Geisen, H. P. & Roelcke, D. (1978): Identification of I, i, Pr1-3 and Gd antigens in the human kidney: possible relevance to hyperacute graft rejection induced by cold agglutinins. Clin. Exp. Immunol. 33, 276–282.PubMedGoogle Scholar
  23. 23.
    Lisowska, E. & Roelcke, D. (1973): Differentiation of anti-Pr1, and anti-Pr2 — sera with periodate-oxidized erythrocyte glycoproteins. Blut 26, 339–341.PubMedCrossRefGoogle Scholar
  24. 24.
    Marsh, W. L. & Jenkins, W. J. (1968): Anti-Sp,: the recognition of a new cold auto-antibody. Vox Sang. 15, 177–186.PubMedCrossRefGoogle Scholar
  25. 25.
    Pruzanski, W., Armstrong, M. & Roelcke, D. (1981): New antigenic determinant (Sa) on human lymphocytes and phagocytes. Blut 43, 307–313.PubMedCrossRefGoogle Scholar
  26. 26.
    Pruzanski, W., Roelcke, D., Armstrong, M. & Manly, M. S. (1980): Pr and Gd antigens on human B and T lymphocytes and phagocytes. Clin. Immunol. Immunopathol. 15, 631–641.PubMedCrossRefGoogle Scholar
  27. 27.
    Roelcke, D. (1969): A new serological specificity in cold antibodies of high titre: anti-HD. Vox Sang. 16, 76–79.PubMedCrossRefGoogle Scholar
  28. 28.
    Roelcke, D. (1973): Serological studies on the Pr1/Pr2 antigens using dog erythrocytes. Differentiation of Pr2 from Pr1 and detection of a Pr1 heterogeneity: Pr1h / Pr1d. Vox Sang. 24, 354–361.PubMedCrossRefGoogle Scholar
  29. 29.
    Roelcke, D. (1973): Specificity of IgA cold agglutinins: anti-Pr1. Eur. J. Immunol. 3, 206–212.PubMedCrossRefGoogle Scholar
  30. 30.
    Roelcke, D. (1981): A further cold agglutinin, Fl, recognizing a N-acetylneuraminic acid-determined antigen. Vox Sang. 41, 98–101.PubMedCrossRefGoogle Scholar
  31. 31.
    Roelcke, D. (1981): The Lud cold agglutinin: a further antibody recognizing N-acetylneuraminic acid-determined antigens not fully expressed at birth. Vox Sang. 41, 316–318.PubMedCrossRefGoogle Scholar
  32. 32.
    Roelcke, D. (1981): Pr and Gd antigens. Blood Transfus. Immunohaematol. 24, 27–36.CrossRefGoogle Scholar
  33. 33.
    Roelcke, D. (1984): Reaction of anti-Gd, anti-FI, and anti-Sa cold agglutinins with p erythrocytes. Vox Sang. 46, 161–164.PubMedCrossRefGoogle Scholar
  34. 34.
    Roelcke, D. (1985): Li cold agglutinin: a further antibody recognizing sialic acid-dependent antigens fully expressed on newborn erythrocytes. Vox Sang. 48, 181–183.PubMedCrossRefGoogle Scholar
  35. 35.
    Roelcke, D., Anstee, D. J., Jungfer, H., Nutzenadel, W. & Webb, A. J. (1971): IgG-type cold agglutinins in children and corresponding antigens. Detection of a new Pr antigen: Pra. Vox Sang. 20, 218–229.PubMedCrossRefGoogle Scholar
  36. 36.
    Roelcke, D. & Brossmer, R. (1984): Different fine specificities of human monoclonal anti-Gd cold agglutinins. Protides Biol. Fluids 31, 1075–1082.Google Scholar
  37. 37.
    Roelcke, D., Brossmer, R. & Ebert, W. (1982): Anti-P1,-Gd, and related cold agglutinins: human monoclonal antibodies against neuraminyl groups. Protides Biol. Fluids 29, 619–622.Google Scholar
  38. 38.
    Roelcke, D., Dahr, W. & Kalden, J. R. (1986): A human monoclonal IgMk cold agglutinin recognizing oligosaccharides with immunodominant sialyl groups preferentially at the blood group M-specific peptide backbone of glycophorins: anti-Prm. Vox Sang. 51, 207–211.PubMedCrossRefGoogle Scholar
  39. 39.
    Roelcke, D., Ebert, W. & Geisen, H. P. (1976): Anti-Pr3: serological and immunochemical identification of a new anti-Pr subspecificity. Vox Sang. 30, 122–133.PubMedCrossRefGoogle Scholar
  40. 40.
    Roelcke, D., Ebert, W., Metz, J. & Weicker, H. (1971): I-, MN-, and Pr1/Pr2-activity of human erythrocyte glycoprotein fractions obtained by ficin treatment. Vox Sang. 21, 352–361.PubMedCrossRefGoogle Scholar
  41. 41.
    Roelcke, D., Hack, H., Kreft, H. & Gross, H. J. (1998): α2,3-specific desialylation of human red cells: effect on the autoantigens of the Pr, Sa and Sia-l1,-b1,-Ib1 series. Vox Sang. 74, 109–112.PubMedCrossRefGoogle Scholar
  42. 42.
    Roelcke, D., Hack, H., Kreft, H., Macdonald, B., Pereira, A. & Habibi, B. (1993): IgA cold agglutinins recognize Pr and Sa antigens expressed on glycophorins. Transfus. 33, 472–475.CrossRefGoogle Scholar
  43. 43.
    Roelcke, D., Hengge, U. & Kirschfink, M. (1990): Neolacto (type-2 chain) sialoautoantigens recognized by human cold agglutinins. Vox Sang. 59, 235–239.PubMedCrossRefGoogle Scholar
  44. 44.
    Roelcke, D. & Kreft, H. (1984): Characterization of various anti-Pr cold agglutinins. Transfus. 24, 210–213.CrossRefGoogle Scholar
  45. 45.
    Roelcke, D., Kreft, H., Northoff, H. & Gallasch, E. (1991): Sia-b1 and I antigens recognized by Mycoplasma pneumoniae-induced cold agglutinins. Transfus. 31, 627–631.CrossRefGoogle Scholar
  46. 46.
    Roelcke, D., Kreft, H. & Pfister, A. M. (1984): Cold agglutinin Vo. An IgMA. monoclonal human antibody recognizing a sialic acid determined antigen fully expressed on newborn erythrocytes. Vox Sang. 47, 236–241.PubMedCrossRefGoogle Scholar
  47. 47.
    Roelcke, D., Pruzanski, W., Ebert, W., Römer, W., Fischer, E., Lenhard, V. & Rauterberg, E. (1980): A new human monoclonal cold agglutinin Sa recognizing terminal N-acetylneuraminyl groups on the cell surface. Blood 55, 677–681.PubMedGoogle Scholar
  48. 48.
    Roelcke, D., Riesen, W., Geisen, H. P. & Ebert, W. (1977): Serological identification of the new cold agglutinin specificity anti-Gd. Vox Sang. 33, 304–306.PubMedCrossRefGoogle Scholar
  49. 49.
    Roelcke, D. & Uhlenbruck, G. (1970): Letter to the editor. Vox Sang. 18, 478–479.PubMedCrossRefGoogle Scholar
  50. 50.
    Roelcke, D. & Weber, M. T. (1984): Simultaneous occurrence of anti-FI and anti-l cold agglutinins in a patient’s serum. Vox Sang. 47, 122–124.PubMedCrossRefGoogle Scholar
  51. 51.
    Römer, W., Seelig, H. P., Lenhard, V. & Roelcke, D. (1979): The distribution of l/i, Pr, and Gd antigens in mammalian tissues. Invest. Cell Pathol. 2, 157–165.PubMedGoogle Scholar
  52. 52.
    Salama, A., Pralle, H. & Mueller-Eckhardt, C. (1985): A new red blood cell cold autoantibody (anti-Me). Vox Sang. 49, 277–284.PubMedCrossRefGoogle Scholar
  53. 53.
    Schwarting, G. A., Marcus, D. M. & Metaxas, M. (1977): Identification of sialosylparagloboside as an erythrocyte receptor for an ‘anti-p’ antibody. Vox Sang. 32, 257–261.PubMedCrossRefGoogle Scholar
  54. 54.
    Suttajit, M. & Winzler, R. J. (1971): Effect of modification of N-acetylneuraminic acid on the binding of glycoproteins to influenza virus and on susceptibility to cleavage by neuraminidase. J. Biol. Chem. 246, 3398–3404.PubMedGoogle Scholar
  55. 55.
    Tonthat, H., Rochant, H., Henry, A., Leporrier, M. & Dreyfus, B. (1976): A new case of monoclonal IgA kappa cold agglutinin with anti-Pr1d specificity in a patient with persistent HB antigen cirrosis. Vox Sang. 30, 464–468.PubMedCrossRefGoogle Scholar
  56. 56.
    Uemura, K. I., Roelcke, D., Nagai, Y. & Feizi, T. (1984): The reactivities of human erythrocyte autoantibodies anti-Pr2, anti-Gd, Fl, and Sa with gangliosides in a chromatogram binding assay. Biochem. J. 219, 865–874.PubMedGoogle Scholar
  57. 57.
    Watanabe, K., Powell, M. & Hakomori, S. I. (1978): Isolation and characterization of a novel fucoganglioside of human erythrocyte membranes. J. Biol. Chem. 253, 8962–8967.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für Medizinische BiochemieUniversität WienViennaAustria

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