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Advances in Research on Neurodegeneration pp 123–133Cite as

The myelin oligodendrocyte glycoprotein (MOG): a model for antibody-mediated demyelination in experimental autoimmune encephalomyelitis and multiple sclerosis

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Summary

The myelin oligodendrocyte glycoprotein (MOG) is a major target for autoantibody mediated demyelination in experimental autoimmune encephalomyelitis (EAE). In the current review we discuss the epitope specificity of this antibody response, in particular evidence suggesting that pathogenic anti-MOG antibodies are preferentially directed against conformationdependent epitopes present on the extracellular immunoglobulin domain of the protein. Surprisingly, recent data suggest that this autoimmune response is in part regulated by polymorphisms in the MOG gene itself, an observation that may have important implications for the genetic and immunological stratification of patients with multiple sclerosis.

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Authors and Affiliations

  1. Department of Neuroimmunology, Max-Planck-Institute for Neurobiology, Am Klopferspitz 18a, D-82152, Planegg-Martinsried, Federal Republic of Germany

    A. Stefferl, U. Brehm & Dr. C. Linington

Authors
  1. A. Stefferl
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  2. U. Brehm
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  3. Dr. C. Linington
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Editor information

Editors and Affiliations

  1. Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan

    Y. Mizuno

  2. Neurodegenerative Disorders Centre, Faculty of Medicine, University Hospital, Vancouver, B.C., Canada

    D. B. Calne

  3. Clinical Research, Schering AG, Berlin, Federal Republic of Germany

    R. Horowski

  4. Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  5. Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    P. Riederer

  6. Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel

    M. B. H. Youdim

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© 2000 Springer-Verlag Wien

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Stefferl, A., Brehm, U., Linington, C. (2000). The myelin oligodendrocyte glycoprotein (MOG): a model for antibody-mediated demyelination in experimental autoimmune encephalomyelitis and multiple sclerosis. In: Mizuno, Y., Calne, D.B., Horowski, R., Poewe, W., Riederer, P., Youdim, M.B.H. (eds) Advances in Research on Neurodegeneration. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6284-2_10

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  • DOI: https://doi.org/10.1007/978-3-7091-6284-2_10

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7246-9

  • Online ISBN: 978-3-7091-6284-2

  • eBook Packages: Springer Book Archive

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