The myelin oligodendrocyte glycoprotein (MOG): a model for antibody-mediated demyelination in experimental autoimmune encephalomyelitis and multiple sclerosis

  • A. Stefferl
  • U. Brehm
  • C. Linington
Conference paper


The myelin oligodendrocyte glycoprotein (MOG) is a major target for autoantibody mediated demyelination in experimental autoimmune encephalomyelitis (EAE). In the current review we discuss the epitope specificity of this antibody response, in particular evidence suggesting that pathogenic anti-MOG antibodies are preferentially directed against conformationdependent epitopes present on the extracellular immunoglobulin domain of the protein. Surprisingly, recent data suggest that this autoimmune response is in part regulated by polymorphisms in the MOG gene itself, an observation that may have important implications for the genetic and immunological stratification of patients with multiple sclerosis.


Multiple Sclerosis Experimental Autoimmune Encephalomyelitis Experimental Allergic Encephalomyelitis Brown Norway Myelin Debris 


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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • A. Stefferl
    • 1
  • U. Brehm
    • 1
  • C. Linington
    • 1
  1. 1.Department of NeuroimmunologyMax-Planck-Institute for NeurobiologyPlanegg-MartinsriedFederal Republic of Germany

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