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Biologic and geographic differences between vaccine and clinical varicella-zoster virus isolates

  • Conference paper
Immunity to and Prevention of Herpes Zoster

Summary

Vaccine and wild-type strains of varicella-zoster virus differ both in their biologic characteristics and in the clinical manifestations of infection caused by each strain. The biologic differences described for the vaccine strain (temper­ature sensitivity and host cell preference) probably reflect the methods used to adapt the wild-type strain to the in vitro growth conditions imposed during the at­tenuation process in cell culture. In addition, restriction fragment polymorphisms have been described that reflect geographic strain variations between the parental virus used to develop the vaccine strain and other wild-type strains. These poly­morphisms have been exploited as tools for the identification and differentiation of vaccine and wild-type strains in clinical studies. Infection with the wild-type strain results in the typical extensive rash of varicella, frequent transmission to other susceptible contacts, establishment of latency, and in some individuals, re­activation with the clinical picture of zoster. Infection with the vaccine strain results in the development of a protective immune response, minimal rash in a minority of individuals, rare transmission to other susceptible contacts, and a greatly reduced risk of zoster.

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Authors and Affiliations

  1. Columbia University, New York, New York, USA

    P. S. LaRussa & A. A. Gershon

  2. Division of Pediatric Infectious Diseases, College of Physicians & Surgeons, PH 4 West-462, 622 West 168th St, New York, New York, 10032, USA

    P. S. LaRussa

Authors
  1. P. S. LaRussa
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  2. A. A. Gershon
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Editors and Affiliations

  1. Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, USA

    Anne A. Gershon

  2. Department of Microbiology and Immunology, Stanford University, Stanford, USA

    Ann M. Arvin

  3. Arthropod-borne and Infectious Diseases Laboratory, Colorado State University, Fort Collins, USA

    Charles H. Calisher

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© 2001 Springer-Verlag Wien

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LaRussa, P.S., Gershon, A.A. (2001). Biologic and geographic differences between vaccine and clinical varicella-zoster virus isolates. In: Gershon, A.A., Arvin, A.M., Calisher, C.H. (eds) Immunity to and Prevention of Herpes Zoster. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6259-0_5

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  • DOI: https://doi.org/10.1007/978-3-7091-6259-0_5

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83555-5

  • Online ISBN: 978-3-7091-6259-0

  • eBook Packages: Springer Book Archive

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