Varicella-zoster virus with a lost gE epitope: evidence for immunological pressure by the human antibody response

  • J. A. Padilla
  • C. Grose
Conference paper


The varicella-zoster virus (VZV) genome contains about 70 open reading frames (ORF). ORF 68 codes for glycoprotein gE, formerly called gp1, which is the predominant VZV glycoprotein; gE is a typical type 1 transmembrane protein with 623 amino acids. Recently, a variant virus was discovered which has a mutation in gE codon 150; this mutation converts an aspartic acid into an asparagine residue.


Herpes Zoster Cell Epitope Variant Virus Antibody Dependent Cellular Cytotoxicity Varicella Vaccine 
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Copyright information

© Springer-Verlag Wien 2001

Authors and Affiliations

  • J. A. Padilla
    • 1
    • 2
  • C. Grose
    • 1
  1. 1.Departments of Microbiology & PediatricsUniversity of IowaIowa CityUSA
  2. 2.Department of PediatricsUniversity of Iowa HospitalIowa CityUSA

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