Immune evasion mechanisms of varicella-zoster virus

  • A. Abendroth
  • A. Arvin
Conference paper


Varicella-zoster virus can to modulate the expression of class I and class II major histocompatibility (MHC) molecules. MHC class I expression is downregulated in VZV-infected T cells as well as in fibroblasts. VZV-infected cells do not respond to exposure to interferon-γ (IFN-γ) by upregulation of MHC class II expression. However, MHC class II expression is induced when cells are treated with IFN-y before VZV infection. These effects on MHC class I and class II expression can be expected to interfere transiently with adaptive immune responses of the host, mediated by CD4 and CD8 T cells, ensuring that the virus has sufficient opportunity for transmission to susceptible contracts.


Major Histocompatibility Complex Class Varicella Zoster Virus Transporter Associate With Antigen Process Varicella Zoster Virus Infection Immune Evasion Mechanism 
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Copyright information

© Springer-Verlag Wien 2001

Authors and Affiliations

  • A. Abendroth
    • 1
    • 2
  • A. Arvin
    • 1
    • 3
  1. 1.Stanford University School of MedicineStanfordUSA
  2. 2.Centre for Virus Research, Westmead Millennium, Institute of Health ResearchUniversity of SydneyWestmeadAustralia
  3. 3.Stanford University School of MedicineStanfordUSA

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