Abstract
It has been suggested that tyrosine kinases are involved in smooth muscle contraction [1] induced by hemolysate or other spasmogens and might be involved in cerebral vasospasm. Mitogen-activated protein kinase (MAPK), a tyrosine kinase substrate, was activated by oxyhemoglobin (OxyHb) [5] and hemolysate [9] and contributed to cerebral arterial contraction. MAPK inhibitor PD98059 reduced the contraction of a rabbit basilar artery by hemolysate [9] and endothelin-1 [8].
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Zubkov, A.Y., Rollins, K.S., McGehee, B., Parent, A.D., Zhang, J.H. (2001). Role of Mitogen-Activated Protein Kinase in the Contractions of Rabbit Basilar Artery Induced by Hemolysate, Oxyhemoglobin, and Bloody CSF. In: Seiler, R.W., Steiger, HJ. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 77. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6232-3_6
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DOI: https://doi.org/10.1007/978-3-7091-6232-3_6
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