Abstract
Fasudil HCl (HA1077, AT877, Eril) was first introduced as a unique vasodilator and intracellular calcium antagonist. It dilated spastic basilar artery by the intravenous injection on day 7 in a two-hemorrhage canine model of chronic cerebral vasospasm. Effectiveness of Fasudil on symptomatic and angiographic vasospasm, cerebral infarction by spasm and clinical outcome had been shown by a double blind trial in patients. Now, it is widely used in Japan in patients with aneurysmal subarachnoid hemorrhage. Current and approved use of Fasudil (30 mg iv 3 times a day for 14 days) ameliorates risk of spasm by about 50%.
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© 2001 Springer-Verlag
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Shibuya, M., Asano, T., Sasaki, Y. (2001). Effect of Fasudil HCl, a Protein Kinase Inhibitor, on Cerebral Vasospasm. In: Seiler, R.W., Steiger, HJ. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 77. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6232-3_42
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DOI: https://doi.org/10.1007/978-3-7091-6232-3_42
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83650-7
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