Skip to main content
SpringerLink
Log in

Sequential Changes of Oxyhemoglobin in Drained Fluid of Cisternal Irrigation Therapy — Reference to the Effect of Ascorbic Acid

  • Conference paper
Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 77))

Abstract

We have been using cisternal irrigation therapy with urokinase (UK) and ascorbic acid (AsA) for prevention of symptomatic vasospasm after aneurysmal subarachnoid hemorrhage (SAH), and excellent results were obtained [3]. In this therapy, UK is used to dissolve the residual clot and AsA is added to degenerate oxyhemoglobin (Oxy-Hb), one of the strongest spasmogenic substances [4]. Previous experimental studies [1, 5] revealed the effect of AsA in degenerating Oxy-Hb. The present study intends to evaluate the effect of AsA in clinical cases by measuring Oxy-Hb concentration of drained fluid sequentially.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kawakami M, Kodama N, Toda N (1991) Suppression of the cerebral vasospastic actions of oxyhemoglobin by ascorbic acid. Neurosurgery 28: 33–40

    Article  PubMed  CAS  Google Scholar 

  2. Kodama N, Mizoi K, Sakurai Y, Suzuki J (1980) Incidence and onset of vasospasm. In: Wilkins RH (ed) Cerebral arterial vasospasm. Williams and Wilkins, Baltimore, p 361–365

    Google Scholar 

  3. Kodama N, Sasaki T, Kawakami M, Sato M, Asari J (2000) Cisternal irrigation therapy with urokinase and ascorbic acid for prevention of vasospasm after aneurysmal subarachnoid hemorrhage: outcome in 217 patients. Surg Neurol 53: 110–118

    Article  PubMed  CAS  Google Scholar 

  4. Osaka K (1977) Prolonged vasospasm by the breakdown products of erythrocytes. J Neurosurg 47: 403–411

    Article  PubMed  CAS  Google Scholar 

  5. Sato M (1987) Prevention of cerebral vasospasm: experimental studies on the degradation of oxyhemoglobin by ascorbic acid. Fukushima J Med Sei 33: 55–70

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Fukushima Medical School, Fukushima, Japan

    Y. Konno M.D., T. Sato, K. Suzuki, M. Matsumoto, T. Sasaki & N. Kodama

Authors
  1. Y. Konno M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. Kodama
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Inselspital, Neurochirurgische Univ.-Klinik, Bern, Switzerland

    R. W. Seiler

  2. Klinikum Großhadern, Neurochirurgische Univ.-Klinik, München, Germany

    H.-J. Steiger

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag

About this paper

Cite this paper

Konno, Y., Sato, T., Suzuki, K., Matsumoto, M., Sasaki, T., Kodama, N. (2001). Sequential Changes of Oxyhemoglobin in Drained Fluid of Cisternal Irrigation Therapy — Reference to the Effect of Ascorbic Acid. In: Seiler, R.W., Steiger, HJ. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 77. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6232-3_35

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6232-3_35

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83650-7

  • Online ISBN: 978-3-7091-6232-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation