Abstract
Vasospasm is believed to be primarily due to the release of substances from the subarachnoid clot that act upon the arterial wall to contract the artery initially and then produce pharmacological and morphological changes in the artery [2]. Numerous questions remain. For example, hemoglobin is an important spasmogen but how it causes vasospasm is not clearly understood. Whether other interactions between the brain and cerebral arteries are involved for the complete manifestations of vasospasm to occur is also unknown. In this experiment dialysis membranes of differing molecular weight cutoffs were placed between subarachnoid blood clot and the middle cerebral artery and brain of cynomolgus monkeys in order to study the molecular weight of the interaction required between clot and brain/artery to produce vasospasm.
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References
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© 2001 Springer-Verlag
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Macdonald, R.L. et al. (2001). Molecular Weight Interactions in Experimental Vasospasm. In: Seiler, R.W., Steiger, HJ. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 77. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6232-3_25
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DOI: https://doi.org/10.1007/978-3-7091-6232-3_25
Publisher Name: Springer, Vienna
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