Abstract
Many investigators have tried to clarify the pathogenesis of vasospasm and to treat or to prevent vasospasm by its reversal [4]. However, the mechanism of spontaneous resolution, one of the crucial features of vasospasm, has not been sufficiently investigated [10]. We studied the intrinsic mechanism of spasmolysis and report the possible role of heme oxygenase (HO)-1 gene induction against vasospasm.
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References
Choi AMK, Alam J (1996) Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 15: 9–19
Everse J, Hsia N (1997) The toxicities of native and modified hemoglobins. Free Radic Biol Med 22: 1075–1099
Kuroki M, Kanamaru K, Suzuki H, Waga S, Semba R (1998) Effect of vasospasm on heme oxygenases in a rat model of subarachnoid hemorrhage. Stroke 29: 683–689
Macdonald RL, Weir BKA (1991) A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke 22: 971–982
Maines MD (1997) The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37: 517–554
Mccoubrey Jr. WK, Huang TJ, Maines MD (1997) Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem 247: 725–732
Morita T, Kourembanas S (1995) Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J Clin Invest 96: 2676–2682
Ono S, Zhang ZD, Marton LS, Yamini B, Windmeyer E, Johns L, Kowalczuk A, Lin G, Macdonald RL (2000) Heme oxygenase-1 and ferritin are increased in cerebral arteries after subarachnoid hemorrhage in monkeys. J Cereb Blood Flow Metab 20: 1066–1076
Pluta RM, Afshar JKB, Boock RJ, Oldfield EH (1998) Temporal changes in perivascular concentration of oxyhemoglobin, deoxyhemoglobin, and methemoglobin after subarachnoid hemorrhage. J Neurosurg 88: 557–561
Suzuki H, Kanamaru K, Tsunoda H, Inada H, Kuroki M, Sun H, Waga S, Tanaka T (1999) Heme oxygenase-1 gene induction as an intrinsic regulation against delayed cerebral vasospasm in rats. J Clin Invest 104: 59–66
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Suzuki, H. et al. (2001). The Functional Significance of Heme Oxygenase-1 Gene Induction in a Rat Vasospasm Model. In: Seiler, R.W., Steiger, HJ. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 77. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6232-3_19
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DOI: https://doi.org/10.1007/978-3-7091-6232-3_19
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83650-7
Online ISBN: 978-3-7091-6232-3
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