Pathophysiology of BBB
The CNS macro-and micro-vessels occupy a significant 25 to 30% of the total brain volume. Continuous tight-junctioned cerebral capillary endothelium comprising the BBB needs to be viewed as two separate impermeable cellular membranes, one on the inside of the vessel wall (luminal side) and the other on the outside (abluminal side) separated by 300-to 500-nm thick cytoplasm. The surface area of cerebral capillary endothelium is approximately 100 cm2 per gram of brain tissue. In the adult human brain, the total surface area of micro vasculature is 12 m2, the total length of capillaries is 650 km, the diameter of a capillary lumen is approximately 6 μm, and the capillaries are 40 μm apart.
KeywordsArachidonic Acid Brain Oedema Cerebral Oedema Capillary Endothelial Cell Vasogenic Oedema
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