Anatomy of the BBB
The central nervous system (CNS) takes its origin from the ectodermal tissue. In the blastula, those cells, which will form the CNS, invaginate to create a depression: the tips of this structure fuse in order to develop a tube. During the early stages, a single cell layer constitutes this tube. During the developmental stages, the differentiation phenomena determine the creation of flexures, folds, depressions, invaginations, and thickening of the different cerebral regions, to create the complexity of the adult CNS.
KeywordsTight Junction Ependymal Cell Brain Capillary Adult Central Nervous System Paracellular Transport
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