The Concept of the BBB: A Historical Perspective
The concept of a vascular barrier arose at the turn of the century. The discovery of the BBB, which is generally attributed to Goldmann, fell within the early years of neurosurgery, when neurosurgeons tried to cope with a multitude of life-threatening complications, such as brain oedema, the relation of which to the BBB was not yet recognised. The attitude of neurosurgeons toward the barrier may since then be characterised as an aifair of love and hate; love and the fear to cause it any harm, and hate when it frustrates our therapeutic efforts or behaves in an unexpected way.
KeywordsBrain Oedema Lipid Solubility Cerebral Blood Vessel Cerebral Endothelial Cell Vascular Barrier
Unable to display preview. Download preview PDF.