Neurobiology of Epileptogenesis in the Temporal Lobe

  • L. Jutila
  • A. Immonen
  • K. Partanen
  • J. Partanen
  • E. Mervaala
  • A. Ylinen
  • I. Alafuzoff
  • L. Paljärvi
  • K. Karkola
  • M. Vapalahti
  • A. Pitkänen
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 27)


Molecular and network changes that are proposed to underlie the development of spontaneous seizures are best understood in subjects with symptomatic aetiology for temporal lobe epilepsy (TLE). Symptomatic TLE typically develops in three phases (Fig. 1): brain damage → latency phase or epileptogenesis → appearance of spontaneous seizures or epilepsy which can be easy to control or turn out to be drug-refractory over the time. According to some authors, the primary epileptogenesis is followed by a secondary epileptogenesis; that is, activity of primary focus leads to the appearance of an independent secondary focus over the time [61]. It is still controversial, however, whether and at which conditions secondary epileptogenesis can occur in the human brain.


Granule Cell Status Epilepticus Dentate Gyrus Temporal Lobe Epilepsy Entorhinal Cortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag/Wien 2002

Authors and Affiliations

  • L. Jutila
    • 1
    • 2
  • A. Immonen
    • 3
  • K. Partanen
    • 4
  • J. Partanen
    • 5
  • E. Mervaala
    • 5
  • A. Ylinen
    • 1
    • 2
  • I. Alafuzoff
    • 1
    • 6
  • L. Paljärvi
    • 6
  • K. Karkola
    • 7
  • M. Vapalahti
    • 3
  • A. Pitkänen
    • 1
    • 8
  1. 1.Department of Neuroscience and NeurologyUniversity of KuopioKuopioFinland
  2. 2.Department of NeurologyKuopio University HospitalKuopioFinland
  3. 3.Department of NeurosurgeryKuopio University HospitalKuopioFinland
  4. 4.Department of Clinical RadiologyKuopio University HospitalKuopioFinland
  5. 5.Department of Clinical NeurophysiologyKuopio University HospitalKuopioFinland
  6. 6.Department of PathologyKuopio University HospitalKuopioFinland
  7. 7.Department of Forensic MedicineKuopio University HospitalKuopioFinland
  8. 8.Epilepsy Research LaboratoryA.I. Virtanen Institute for Molecular SciencesKuopioFinland

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