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Anmerkungen zu den atypischen Neuroleptika

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Fortschritte in Psychiatrie und Psychotherapie
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Zusammenfassung

Es war das Ziel dieser Anmerkungen, auf einige methodologische Mängel publizierter Studien aufmerksam zu machen, die Bedeutung der Äquivalenzdosen zu unterstreichen, zwei seltene, aber gravierende Nebenwirkungen (hyperglykämische Reaktionen und Entzugssymptome) zu erwähnen, die zu beobachtenden Gewichtszunahmen näher zu beleuchten und ein sehr vorläufiges Statement zu den Spätdyskinesien unter atypischen Neuroleptika abzugeben.

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Literatur

  1. Allison D B, Mentore J L, Heo M, Chandler L P, Cappelleri J C, Infante M C, Weiden P J (1999) Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156: 1686–1696

    PubMed  CAS  Google Scholar 

  2. Bandelow B, Rüther E (Hrsg) (1998) Therapie mit klassischen und neuen Neuroleptika. Springer: Berlin etc.

    Book  Google Scholar 

  3. Barnes T R E, McPhillips M A (1999) Critical analysis and comparison of the side-effect and safety profiles of the new antipsychotics. Br J Psychiatry 174(Suppl 38): 34–43

    Google Scholar 

  4. Beasley C M, Dellva M A, Tamura R N, Morgenstern H, Glazer W M, Ferguson K, Tollefson G D (1999) Randomised double-blind comparison of the incidence of tardive dyskinesia in patients with schizophrenia during long-term treatment with olanzapine or haloperidol. Br J Psychiatry 174: 23–30

    Article  PubMed  CAS  Google Scholar 

  5. Beasley C M, Tollefson G, Tran P, Satterlee W,Sanger T, Hamilton S, and The Olanzapine HGAD Study Group (1996) Olanzapine versus placebo and haloperidol. Acute phase results of the North American double-blind olanzapine trial. Neuropsychopharmacology 14(2): 111–123

    Article  PubMed  CAS  Google Scholar 

  6. Chouinard G, Bradwejn J, Annable L, Jones B D, Ross-Chouinard A (1984) Withdrawal symptoms after long-term treatment with low-potency neuroleptics. J Clin Psychiatry 45: 500–502

    PubMed  CAS  Google Scholar 

  7. Deiser R, Schindler R (1980) Das Verlaufsbild langjähriger Behandlungen mit Fluphenazindekanoat (Dapotum D). Psychiatria Clin 13:193–205

    CAS  Google Scholar 

  8. Dieterle D M, Müller-Spahn F, Ackenheil M (1991) Wirksamkeit und Verträglichkeit von Zotepin im Doppelblindvergleich mit Perazin bei schizophrenen Patienten. Fortschr Neurol Psychiatr 59(Suppl 1): 18–22

    Article  PubMed  Google Scholar 

  9. Editorial (2000) Neuroleptikum Olanzapin (ZYPREXA): Agranulozytose und malignes neuroleptisches Syndrom. arznei-telegramm 31(3): 31–32

    Google Scholar 

  10. Eerdekens M, Rasmussen M, Vermeulen A, Lowenthal R, Van Peer A (2000) Kinetics and safety of a novel risperidone depot fomulation (poster) 10th Biennial Winter Workshop on Schizphrenia. Davos, Febr. 5–11, 2000

    Google Scholar 

  11. Ekblom B, Eriksson K, Lindström L H (1984) Supersensitivity psychosis in schizophrenic patients after sudden clozapine withdrawal. Psychopharmacology 83:293–294

    Article  PubMed  CAS  Google Scholar 

  12. Esquirol J E D (1968) Von den Geisteskrankheiten. Hans Huber: Bern etc.: 84 (Übersetzung und Nachdruck von 1816)

    Google Scholar 

  13. Hayek D von, Hüttl, V Reiss J, Schweiger H-D, Füessl H S (1999) Hyperglykämie und Ketoazidose unter Olanzapin. Nervenarzt 70: 836–837

    Google Scholar 

  14. Heim M, Morgner J (1997) Feinmotorische Untersuchungen: Risperidon-Dosierung bei schizophrenen Patienten. TW Neurologie Psychiatrie 11: 587–589

    Google Scholar 

  15. Johnson A L, Johnson D A W (1995) Peer review of „Risperidone in the treatment of patients with chronic schizophrenia: a multi-national, multi-centre, double-blind, parallel-group study versus haloperidol“. Br J Psychiatry 166: 727–733

    Google Scholar 

  16. Kane J, Ingenito G, Ali M (2000) Efficacy of aripiprazole in psychotic disorders: comparison with haloperidol and placebo (abstract). Schizophr Res 41(1, special issue): 39

    Article  Google Scholar 

  17. Kasper S, Hale A, Azorin J-M, Möller H-J (1999) Benefit-risk evaluation of olanzapine, risperidone and sertindole in the treatment of schizophrenia. Eur Arch Psychiatry Clin Neurosci 249(Suppl 2): II/2–1I/14

    Article  Google Scholar 

  18. Kraus T, Haack M, Schuld A, Hinze-Selch D, Kuhn M, Uhr M, Pollmächer T (1999) Body weight and leptin plasma levels during treatment with antipsychotic drugs. Am J Psychiatry 156: 312–314

    PubMed  CAS  Google Scholar 

  19. Kulhanek F (1994) Was wissen wir über die Beziehung der neuroleptischen Therapie zur Prävalenz, Inzidenz und Persistenz der Spätdyskinesien. In: Lange E, Hoffmann W (Hrsg) 6. Dresdner Symposium zu aktuellen Aspekten der Psychopharmakotherapie. Gustav Fischer: Jena etc.: 156–180

    Google Scholar 

  20. Kulhanek F (1995) Über die Bedeutung neuroleptischer Äquivalenzdosen, In: Hinterhuber H, Fleischhacker W W, Meise U (Hrsg) Die Behandlung der Schizophrenie. State of the Art. Integrative Psychiatrie: Innsbruck etc.: 229–239

    Google Scholar 

  21. Laux G, König W Jones M (2000) Inpatient treatment of schizophrenia: a study of two leading atypical neuroleptics (abstract). Schizophr Res 41 (1, special issue): 38

    Article  Google Scholar 

  22. Leucht S, Pitschel-Walz G, Abraham D, Kissling W (1999) Efficacy and extrapyramidal side effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials. Schizophr Res 35: 51–68

    Article  PubMed  CAS  Google Scholar 

  23. Lucey J V, Brook S, Daniel D G, Reeves K R, Harrigan E P (2000) Intramuscular (im) ziprasidone: a novel treatment for the short-term management of agitated psychotic patients (abstract). Schizophr Res 41(1, special issue): 208

    Article  Google Scholar 

  24. Marder S R, Meibach R C (1994) Risperidone in the treatment of schizophrenia. Am J Psychiatry 151(6): 825–835

    PubMed  CAS  Google Scholar 

  25. McEvoy J P, Hogarty G E, Steingard S (1991) Optimal dose of neuroleptic in acute schizophrenia. A controlled study of the neuroleptic threshold and higher haloperidol dose. Arch Gen Psychiatry 48: 739–745

    Article  PubMed  CAS  Google Scholar 

  26. Möller H-J, Müller N (Hrsg) (1999) Atypische Neuroleptika: der Stellenwert in der Therapie schizophrener Psychosen. Dr. Dietrich Steinkopff: Darmstadt

    Google Scholar 

  27. Naher D, Lambert M, Krausz M (1999) Atypische Neuroleptika in der Behandlung schizophrener Patienten. Uni-Med: Bremen

    Google Scholar 

  28. Peuskens J, on behalf of the Risperidone Study Group (1995) Risperidone in the treatment of patients with chronic schizophrenia: a multi-national, multi-centre, double-blind, parallel-group study versus haloperidol. Br J Psychiatry 166: 712–726

    Google Scholar 

  29. Pickar D, Lieberman J A (1996) New strategies for treating psychosis: general discussion. J Clin Psychiatry 57(Suppl): 93

    Google Scholar 

  30. Richelson E (1996) Preclinical pharmacology of neuroleptics: focus on new generation compounds. J Clin Psychiatry 57(Suppl 11): 4–11

    PubMed  CAS  Google Scholar 

  31. Sacks O (1991) Awakenings-Zeit des Erwachens. Rowohlt Taschenbuch Verlag: Reinbek bei Hamburg

    Google Scholar 

  32. Saletu B, Küfferle B, Grünberger J, Földes P Topitz A, Anderer P (1994) Clinical, EEG mapping and psychometric studies in negative schizophrenia: comparative trials with amisulpride and fluphenazine. Neuropsychobiology 29: 125–135

    Google Scholar 

  33. Simpson G M, Lee J H, Shrivastava R K (1978) Clozapine in tardive dyskinesia. Psychopharmacology 56: 75–80

    Article  PubMed  CAS  Google Scholar 

  34. Tollefson G D, Beasley C M, Tamura R N, Tran P V, Potvin J H (1997) Blind, controlled, long-term study of the comparative incidence of treatment-emergent tardive dyskinesia with olanzapine or haloperidol. Am J Psychiatry 154(9): 1248–1254

    PubMed  CAS  Google Scholar 

  35. Weiden P, Aquila R, Standard J (1996) Atypical antipsychotic drugs and long-term outcome in schizophrenia. J Clin Psychiatry 57(Suppl 11): 53–60

    PubMed  CAS  Google Scholar 

  36. Wetzel H, Bardeleben U von, Holsboer F, Benkert O (1991) Zotepin versus Perazin bei Patienten mit paranoider Schizophrenie: eine doppelblind-kontrollierte Wirksamkeitsprüfung. Fortschr Neurol Psychiatr 59(Suppl 1): 23–29

    Article  PubMed  Google Scholar 

  37. Zimbroff D L, Kane J M, Tamminga C A, Daniel D G, Mack R N, Wozniak P J, Sebree T B, Wallin B A, Kashkin K B, The Sertindole Study Group (1997) Controlled, dose-response study of sertindole and haloperidol in the treatment of schizophrenia. Am J Psychiatry 154: 82–91

    Google Scholar 

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© 2002 Springer-Verlag Wien

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Kulhanek, F. (2002). Anmerkungen zu den atypischen Neuroleptika. In: Peter, K. (eds) Fortschritte in Psychiatrie und Psychotherapie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6169-2_4

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  • DOI: https://doi.org/10.1007/978-3-7091-6169-2_4

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83557-9

  • Online ISBN: 978-3-7091-6169-2

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