A broader horizon of Alzheimer pathogenesis: ALZAS — an early serum biomarker?
Recently, a novel risk gene protein expressed in elderly patientswith the diagnosis of Alzheimer disease (AD) was discovered on chromosome 21 within the APP (amyloid precursor protein) region. This 79 amino acidprotein, ALZAS (Alzheimer Associated Protein) contains the β-amyloid peptide 1–42 fragment, the APP transmembrane signal, and a unique 12 aminoacid c-terminal which is not present in any known allele of the APP gene.Reverse transcription-peR revealed that the transcript of ALZAS was ex-pressed in cortical and hippocampal regions of human Alzheimer diseasebrain as well as in leukocytes derived from AD patients. Most specifically, anendogenous antibody was found in patients with confirmed AD, in patientswith depression, and in subjects suggested to have presymptomatic AD,where it was directed against epitopes within the intron encoded amino acidc-terminal sequence.
KeywordsAlzheimer Disease Amyloid Precursor Protein Alzheimer Disease Patient Amyloid Beta Protein Alzheimer Disease Brain
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