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Nerve growth factor and cholinergic CNS neurons studied in organotypic brain slices

Implication in Alzheimer's disease?

  • Conference paper

Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL,volume 62)

Abstract

Nerve growth factor (NGF) is a potent growth factor for cholinergic neurons. The aim of the present study was to investigate if NGF affects cholinergic neurons of the basal nucleus of Meynert (nBM) in organotypic brain slices. In single nBM slices cholinergic neurons rapidly degenerated when incubated without NGF. The number of remaining neurons was rescued by NGF application at any time point. When nBM slices were co-cultured with a cortex slice the number of cholinergic neurons was significantly increased pointing to a trophic influence of the cortex. Incubation with acetylcholine precursors did not affect the survival of cholinergic neurons. There was no significant difference when postnatal day 3 or day 10nBM slices were cultured. In conclusion, NGF is the most potent growth factor for cholinergic neurons and is a promising candidate for treating Alzheimers disease, however the delivery of NGF to the brain must the solved.

Keywords

  • Nerve Growth Factor
  • Cholinergic Neuron
  • Choline Acetyltransferase
  • Nerve Fiber Density
  • Ergic Neuron

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 2002 Springer-Verlag Wien

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Humpel, C., Weis, C. (2002). Nerve growth factor and cholinergic CNS neurons studied in organotypic brain slices. In: Jellinger, K.A., Schmidt, R., Windisch, M. (eds) Ageing and Dementia Current and Future Concepts. Journal of Neural Transmission. Supplementa, vol 62. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6139-5_23

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  • DOI: https://doi.org/10.1007/978-3-7091-6139-5_23

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83796-2

  • Online ISBN: 978-3-7091-6139-5

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