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Timely Research Perspectives in Carbohydrate Chemistry pp 191–204Cite as

The Chameleon of Retaining Glycoside Hydrolases and Retaining Glycosyl Transferases: The Catalytic Nucleophile

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Summary

This paper addresses the existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyl transferases. Although the former has now been established beyond doubt, such is not the case with the latter. We report reliable procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogues for the study of the mechanism of action of retaining glycosyl transferases.

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Author information

Authors and Affiliations

  1. Department of Chemistry, The University of Western Australia, 6009, Crawley, WA, Australia

    Robert V. Stick & Andrew G. Watts

Authors
  1. Robert V. Stick
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  2. Andrew G. Watts
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Editor information

Editors and Affiliations

  1. Institute of Organic Chemistry, University of Vienna, Vienna, Austria

    Walther Schmid

  2. Institute of Organic Chemistry, Technical University of Graz, Graz, Austria

    Arnold E. Stütz

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© 2002 Springer-Verlag Wien

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Stick, R.V., Watts, A.G. (2002). The Chameleon of Retaining Glycoside Hydrolases and Retaining Glycosyl Transferases: The Catalytic Nucleophile. In: Schmid, W., Stütz, A.E. (eds) Timely Research Perspectives in Carbohydrate Chemistry. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6130-2_13

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  • DOI: https://doi.org/10.1007/978-3-7091-6130-2_13

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7289-6

  • Online ISBN: 978-3-7091-6130-2

  • eBook Packages: Springer Book Archive

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