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Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma

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Local Therapies for Glioma Present Status and Future Developments

Abstract

Purpose. This was an open-label, dose-escalation trial of intratumoral administration of IL-4 Pseudomonas Exotoxin (NBI-3001) in patients with recurrent malignant glioma.

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References

  1. Bobo RH, Laske DW, Akbasak A et al (1994) Convectionenhanced delivery of macromolecules in the brain. Proc Nat! Acad Sci USA 91: 2076–2080

    Article  CAS  Google Scholar 

  2. Brem H, Piantadosi S, Burger PC et al (1995) Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group. Lancet 345: 1008–1012

    Article  PubMed  CAS  Google Scholar 

  3. DeAngelis LM (2001) Brain tumors. N Engl J Med 344: 114–124

    Article  PubMed  CAS  Google Scholar 

  4. Di Massimo AM, Di Loreto M, Pacilli A et al (1997) Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata. Br J Cancer 75: 822–828

    Article  PubMed  Google Scholar 

  5. Frankel AE, Kreitman RJ, Sausville EA (2000) Targeted toxins. Clin Cancer Res 6: 326–334

    PubMed  CAS  Google Scholar 

  6. Guyotat J, Signorelli F, Frappaz D et al (2000) Is reoperation for recurrence of glioblastoma justified? Oncol Rep 7(4): 899–904

    PubMed  CAS  Google Scholar 

  7. Husain SR, Behari N, Kreitman RJ et al (1998) Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy. Cancer Res 58: 3649–3653

    PubMed  CAS  Google Scholar 

  8. Husain SR, Joshi BH, Puri RK (2001) Interleukin-13 receptor as a unique target for anti-glioblastoma therapy. Int J Cancer 92: 168–175

    Article  PubMed  CAS  Google Scholar 

  9. Jin W, Bi W, Huang ES et al (1999) Glioblastoma cell-specific expression offibroblast growth factor receptor-1 beta requires an intronic repressor ofRNA splicing. Cancer Res 59: 316–519

    PubMed  CAS  Google Scholar 

  10. Joshi BH, Leland P, Asher A et al (2001) In situ expression of interleukin-4 receptors in human brain tumors and cytotoxicity of a recombinant interleukin-4 (IL-4) cytotoxin in primary glioblastoma cell cultures. Cancer Res 61: 8058–8061

    PubMed  CAS  Google Scholar 

  11. Joshi BH, Plautz GE, Puri RK (2001) Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas. Cancer Res 60: 1168–1172

    Google Scholar 

  12. Kreitman RJ, Puri RK, Pastan I (1994) A circularly permuted recombinant interleukin 4 toxin with increased activity. Proc Nat! Acad Sci USA 91: 6889–6893

    Article  CAS  Google Scholar 

  13. Kreitman RJ, Puri RK, Pastan I (1995) Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma. Cancer Res 55: 3357–3363

    PubMed  CAS  Google Scholar 

  14. Kurpad SN, Zhao XG, Wikstrand CJ et al (1995) Tumor antigens in astrocytic gliomas. Glia 15: 244–256

    Article  PubMed  CAS  Google Scholar 

  15. Laske DW, Ilercil O, Akbasak A et al (1994) Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice. J Neurosurg 80: 520–526

    Article  PubMed  CAS  Google Scholar 

  16. Laske DW, Youle RJ, Oldfield EH (1997) Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nat Med 3: 1362–1368

    Article  PubMed  CAS  Google Scholar 

  17. LeMaistre CF, Meneghetti C, Howes L et al (1994) Targeting the EGF receptor in breast cancer treatment. Breast Cancer Res Treat 32: 97–103

    Article  PubMed  CAS  Google Scholar 

  18. Lieberman DM, Laske DW, Morrison PF et al (1995) Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion. J Neurosurg 82: 1021–1029

    Article  PubMed  CAS  Google Scholar 

  19. Liu H, Prayson RA, Estes ML et al (2000) In vivo expression of the interleukin 4 receptor alpha by astrocytes in epilepsy cerebral cortex. Cytokine 12: 1656–1661

    Article  PubMed  CAS  Google Scholar 

  20. Puri RK, Hoon DS, Leland P et al (1996) Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma. Cancer Res 56: 5631–5637

    PubMed  CAS  Google Scholar 

  21. Puri RK, Leland P, Kreitman RJ et al (1994) Human neurological cancer cells Express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein. Int J Cancer 58: 574–581

    Article  PubMed  CAS  Google Scholar 

  22. Puri RK, Leland P, Obiri NI et al (1996) An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity. Cell Immunol 171: 80–86

    Article  PubMed  CAS  Google Scholar 

  23. Rahaman SO, Shrama P, Harbor PC et al (2002) Il-13Ralpha2, a decoy receptor for IL-13 acts as an inhibitor ofIL-4-dependent signal transudation in glioblastoma cells. Cancer Res 62: 1103–1109

    PubMed  CAS  Google Scholar 

  24. Rand RW, Kreitman RJ, Patronas N et al (2000) Intratumoral administration of recombinant circularly permuted interleukin4-Pseudomonas exotoxin in patients with high-grade glioma. Clin Cancer Res 6: 2157–2165

    PubMed  CAS  Google Scholar 

  25. Surawicz TS et al (1999) Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990–1994. Neurooncology 1: 1990–1994

    CAS  Google Scholar 

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© 2003 Springer-Verlag/Wien

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Weber, F.W. et al. (2003). Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma. In: Westphal, M., Tonn, JC., Ram, Z. (eds) Local Therapies for Glioma Present Status and Future Developments. Acta Neurochirurgica Supplements, vol 88. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6090-9_15

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  • DOI: https://doi.org/10.1007/978-3-7091-6090-9_15

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-40355-6

  • Online ISBN: 978-3-7091-6090-9

  • eBook Packages: Springer Book Archive

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