Tumors originating in the central skull base

  • Vinko V. Dolenc


Tumors of the parasellar space (PS) and adjacent regions in the central skull base (CSB) occur most frequently among the middle-aged, but they are also common in the elderly. They also appear in children. Approximately one-half of all histologically benign CSB tumors are meningiomas. Females with meningiomas outnumber their male counterparts by nearly 2: 1. Other benign tumors common at the CSB are neoplasms of the pituitary gland, which may invade one or the other or both PS(s). Craniopharyngiomas, the third most frequent benign CSB tumor, generally occur in the midline, growing upward and posteriorly, only occasionally lateralward into the PS(s). Trigeminal neurinomas, fourth in incidence among benign lesions, are most often unilateral, while chordomas, chondrosarcomas and even chondromas may be unilateral but more commonly extend across the midline. Parasellar tumors in children most commonly are neurinomas of nerve V. Malignant CSB tumors include direct invasion by sarcomas and carcinomas arising from adjacent structures. Even distant metastases appear within the CSB.


Optic Canal Petrous Apex Superior Orbital Fissure Anterior Clinoid Process Petroclival Meningioma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Cushing H. (1922) The meningiomas (dural endotheliomas): their source and favoured seats of origin. Brain 45: 282–316Google Scholar
  2. 2.
    Cushing H., Eisenhardt L. (1938) The meningiomas. Charles C. Thomas, SpringfieldGoogle Scholar
  3. 3.
    Ghim T.T., Seo J.J., O’Brien M., Meacham L., Crocker I., Krawiecki N. (1993) Childhood intracranial meningiomas after high-dose irradiation. Cancer 71: 4091–4095PubMedGoogle Scholar
  4. 4.
    Granick M.S., Martuza R.L., Parker S.W., Ojemann R.G., Montgomery W.W. (1985) Cerebellopontine angle meningiomas: clinical manifestations and diagnosis. Ann Otol, Rhinol Laryngol 94: 34–38Google Scholar
  5. 5.
    Grunberg S.M. (1994) Role of anti progestational therapy meningiomas. Human Reproduction [Suppl]9: 202–207PubMedGoogle Scholar
  6. 6.
    Grunberg S.M., Weiss M.H., Spitz I.M., Ahmadi J., Sadun A., Russell C.A., Lucci L., Stevenson L.L. (1991) Treatment of unresectable meningiomas with the anti progesterone agent mifepristone. J Neurosurg 74: 861–866PubMedGoogle Scholar
  7. 7.
    Harrison M.J., Wolfe D.E., Lau T.S., Mitnick R.J., Sachdev V.P. (1991) Radiation-induced meningiomas: experience at the Mount Sinai Hospital and review of the literature. J Neurosurg 75: 564–574PubMedGoogle Scholar
  8. 8.
    Helseth A., Mork S.J., Johansen A., Tretli S. (1989) Neoplasms of the central nervous system in Norway. IV. A populationbased epidemiological study of meningiomas. APMIS 97: 646–654PubMedGoogle Scholar
  9. 9.
    Kepes J.J. (1982) Meningiomas: biology, pathology and differential diagnosis. Masson, New YorkGoogle Scholar
  10. 10.
    Kepes J.J., Dunlap M.D., O’Boynick P., Terreros D. (1986) Meningioma with multiple rheumatoid nodules. Acta Neuropathologica 70: 314–319PubMedGoogle Scholar
  11. 11.
    Kleihues P., Burger P.C., Scheitauer B.W. (1993) Histological typing of tumours of the central nervous system. Second edition. WHO international histological classification of tumors. Springer, Berlin HeidelbergGoogle Scholar
  12. 12.
    Longstreth W.T. Jr., Dennis L.K., McGuire V.M., Drangsholt M.T., Koepsell T.D. (1993) Epidemiology of intracranial meningioma. Cancer 72: 639–648PubMedGoogle Scholar
  13. 13.
    Mack E.E., Wilson C.B. (1993) Meningiomas induced by high-dose cranial irradiation. J Neurosurg 79: 28–31PubMedGoogle Scholar
  14. 14.
    Nakasu S., Hirano A., Shimura T., Llena J.F. (1987) Incidental meningiomas in autopsy study. Surg Neurol 27: 319–322PubMedGoogle Scholar
  15. 15.
    Preston-Martin S. (1989) Descriptive epidemiology of primary tumors of the brain, cranial nerves and cranial meninges in Los Angeles County. Neuroepidemiology 8: 283–295PubMedGoogle Scholar
  16. 16.
    Rachlin J.R., Rosenblum M.L. (1991) Etiology and biology of meningiomas. In: AI-Mefty O (ed) Meningiomas. Raven, New York, pp 22–37Google Scholar
  17. 17.
    Russell D.S., Rubinstein L.J. (1989) Pathology of tumorurs of the nervous system, 5th edn. Edward Arnold, LondonGoogle Scholar
  18. 18.
    Sedzimir C.B., Frazer A.K., Roberts J.R. (1973) Cranial and spinal meningiomas in a pair of incidental twin boys. J Neurol Neurosurg Psychiatry 36: 368–376PubMedGoogle Scholar
  19. 19.
    Van Buren J.M., Poppen J.L., Horrax G. (1957) Unilateral exophthalmos: a consideration of symptom pathogenesis. Brain 80: 139–175Google Scholar
  20. 20.
    Wood M.W., White R.J., Kernohan J.W. (1957) One hundred intracranial meningiomas found incidentally at necropsy. J Neuropathol Exp Neurol 16: 337–340PubMedGoogle Scholar
  21. 1.
    Ahmadi J., North C.M., Segall H.D., Zee C-S, Weiss M.H. (1986) Cavernous sinus invasion by pituitary adenomas. AJR Am J Roentgenol 146: 257–262PubMedGoogle Scholar
  22. 2.
    Asari J., Yamanobe K., Sasaki T., Yamao N., Kodama N. (1987) A case of prolactinoma associated with craniopharyngioma. No Shinkei Geka 15: 1313–1318PubMedGoogle Scholar
  23. 3.
    Brada M., Ford D., Ashley S., Bliss J.M., Crowley S., Mason M., Rajan B., Traish D. (1992) Risk of second brain tumour after conservative surgery and radiotherapy for pituitary adenoma. Br Med J 304: 1343–1346Google Scholar
  24. 4.
    Dolenc V.V. (1989) Anatomy and surgery of the cavernous sinus. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  25. 5.
    Dolenc V.V. (1997) Transcranial epidural approach to pituitary tumors extending beyond the sella. Neurosurg 41(3): 542–552Google Scholar
  26. 6.
    Fusek I. (1980) Remarks on the tactiPS and techniPS of transsphenoidal surgery for suprasellar pituitary adenomas. Zentralbl Neurochir 41: 209–214PubMedGoogle Scholar
  27. 7.
    Ghosh S, Chandy M.J. (1992) Intrasellar tuberculoma. Clin Neurol Neurosurg 94: 251–252PubMedGoogle Scholar
  28. 8.
    Grisoli F., Vincentelli F., Raybaud C., Harter M., Guibout M., Baldini M. (1983) Intrasellar meningioma. Surg Neurol 20: 36–41PubMedGoogle Scholar
  29. 9.
    Grosskopf D., Chamouard J.M., Bosquet F., Billet R., Poisson M., Buge A. (1987) Pituitary abscess: Study of a case and review of the literature. Neurochirurgie 33: 228–231PubMedGoogle Scholar
  30. 10.
    Guy J., Mancuso A., Beck R., Moster M.L., Sedwick L.A., Quisling R.G., Rhoton A.I. Jr., Protzko E.E., Schiffman J. (1991) Radiation-induced optic neuropathy: A magnetic resonance imaging study. J Neurosurg 74: 426–432PubMedGoogle Scholar
  31. 11.
    Haddad S.F., VanGilder J.C., Menezes A.H. (1991) Pediatric pituitary tumors. Neurosurgery 29: 509–514PubMedGoogle Scholar
  32. 12.
    Hermier M., Turjman F., Tournut P., Laharotte J.C., Sindou M., Froment J.C., Doquesnel J. (1994) Intracranial aneurysm associated with pituitary adenoma shown by MR angiography: Case report. Neuroradiology 36: 115–116PubMedGoogle Scholar
  33. 13.
    Jaffarin-Rea M.L., Derome P., Bataini J.P., Thomopoulos P., Bertagna X., Luton J.P. (1993) Influence of radiotherapy on longterm relapse in clinically non-secreting pituitary adenomas: a retrospective study (1970’1988). Eur J Med 2: 398–403Google Scholar
  34. 14.
    James R.L. Jr., Arsenis G., Stoler M., Neson C., Baran D. (1984) Hypophyseal metastatic renal cell carcinoma and pituitary adenoma: Case report and review of the literature. Am J Med 76: 337–340PubMedGoogle Scholar
  35. 15.
    Jaunsolo M.A., Aguirre M., Bellido D., Castro S., Ruiz-Vadlepenas M.P., Hawkins F.G. (1986) Association of acromegaly and cerebral arterial aneurysm disclosed by a subarachnoid hemorrhage [in French]. Neurochirurgie 32: 266–268PubMedGoogle Scholar
  36. 16.
    Kline L.B., Kim J.Y., Ceballos R. (1985) Radiation optic neuropathy. Ophthalmology 92: 1118–1126PubMedGoogle Scholar
  37. 17.
    Kovacic J.J., Grigsby P.W., Fineberg B.B. (1990) Recurrent pituitary adenomas after surgical resection: The role of radiation therapy. Radiology 177: 273–275Google Scholar
  38. 18.
    Krauss H.R., Siamovits T.L., Sibony P.A., Verbalis J.G., Nelson P.B. (1982) Carotid artery aneurysm simulating pituitary adenoma. J Clin Neuroophtalmol 2: 169–174Google Scholar
  39. 19.
    Nishio S., Tsukamoto H., Fukui M., Matsubara T. (1992) Hypophyseal metastatic hypernephroma mimicking a pituitary adenoma: case report. Neurosurg Rev 15: 319–322PubMedGoogle Scholar
  40. 20.
    Ooi T.C., Russell N.A. (1986) Hypopituitarism resulting from an intraselar carotid aneurysm. Can J Nurol Sci 13: 70–71Google Scholar
  41. 21.
    Pasztor E., Kemeny A.A., Piffko P. (1983) Transsphenoidal surgery for suprasellar pituitary adenomas. Acta Neurochir (Wien) 67: 11–17Google Scholar
  42. 22.
    Paulus P., Paridaens R., Mockel J., Coffernils M., Dhaens J., Baleriaux D., Rodesch G., Rutsaert J., Depierreux M., FlammentDurand J. (1990) Argyrophilic breast carcinoma, single metastasis to the pituitary gland. Bull Cancer (paris) 77: 377–384PubMedGoogle Scholar
  43. 23.
    Ross D.A., Wilson C.B. (1988) Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients. J Neurosurg 68: 854–867PubMedGoogle Scholar
  44. 24.
    Sassolas G., Trouillas J., Treluyer C., Perrin G. (1993) Management for nonfunctioning pituitary adenomas. Acta Endocrinol 1: 21–26Google Scholar
  45. 25.
    Sato K., Hayashi M., Komai T., Kubota T., Kawano H., Handa Y. (1990) Clinical and histological study of pituitary fibrosarcoma following radiotherapy for pituitary adenoma: case report. Neurol Med Chir (Tokyo) 30: 888–892Google Scholar
  46. 26.
    Saul R.F., Hilliker J.K. (1985) Third nerve palsy: The presenting sign of a pituitary adenoma in five patients and the only neurological sign in four patients. J Clin Neuroophtalmol 5: 185–193Google Scholar
  47. 27.
    Scotti G., Yu C.Y., Dillon W.P., Norman D., Colombo N., Newton T.H., De Groot J., Wilson C.B. (1988) MR imaging of cavernous sinus involvement by pituitary adenomas. AJR Am J Roentgenol 151: 799–806PubMedGoogle Scholar
  48. 28.
    Shi T., Farrell M.A., Kaufmann J.C. (1984) Fibrosarcoma complicating irradiated pituitary adenoma. Surg Neurol 22: 277–284PubMedGoogle Scholar
  49. 29.
    Steiner E., Knosp E., Herold C.J., Kramer J., Stiglbauer R., Staniszewski K., Imhof H. (1992) Pituitary adenomas: findings of postoperative MR imaging. Radiology 185: 521–527PubMedGoogle Scholar
  50. 30.
    Sullivan L.J., O’Day J., McNeill P. (1991) Visual outcomes of pituitary adenoma surgery: St Vincent’s Hospital 1968’1987. J Clin Neuroophtalmol 11: 262–267Google Scholar
  51. 31.
    Suzakawa K. (1989) Evaluation of the transcranial approach to pituitary adenomas based on quantitative analysis of pre-and postoperative visual function. Neurol Med Chir (Tokyo) 29: 1012–1019Google Scholar
  52. 32.
    Symon L., Logue V., Mohanty S. (1982) Recurrence of pituitary adenomas after transcranial operation. J Neurol Neurosurg Psychiatry 45: 780–785PubMedGoogle Scholar
  53. 33.
    Tachibana O., Yamaguchi N., Yamashima T., Yamashita J. (1990) Radiation necrosis of the optic chiasm, optic tract, hypothalamus, and upper pons after radiotherapy for pituitary adenoma, detected by gadolinium-enhanced, T1-weighted magnetic resonance imaging: case report. Neurosurgery 27: 640–643PubMedGoogle Scholar
  54. 34.
    Takahashi T., Kuwayama A., Katoh T., Ichihara K., Kageyama N., Sasaki F. (1984) Size reduction of a nonfunctioning pituitary adenoma after bromocritpine therapy: Case report. No Shinkei Geka 12: 71–80PubMedGoogle Scholar
  55. 35.
    Tsuchida T., Tanaka R., Yokoyama M., Sato H. (1983) Rupture of anterior communicating artery aneurysm during transsphenoidal surgery for pituitary adenoma. Surg Neurol 20: 67–70PubMedGoogle Scholar
  56. 36.
    Van Schaardenburg D., Roelfsema F., van Seters A.P., Vielvoye G.J. (1989) Bromocriptine therapy for non-functioning pituitary adenoma. Clin Endocrinol 30: 475–484Google Scholar
  57. 37.
    Weir B. (1992) Pituitary tumors and aneurysms: Case report and review of the literature. Neurosurgery 30: 585–591PubMedGoogle Scholar
  58. 38.
    Wilson C.B. (1990) Role of surgery in the management of pituitary tumors. Neurosurg Clin N Am 1: 139–159PubMedGoogle Scholar
  59. 1.
    Amirchanjan S.E., Lebedev A.N. (1979) The radiological diagnosis of trigeminus neurinomas of the gasserian ganglions. Radiologia Diagnostica 20: 78–85PubMedGoogle Scholar
  60. 2.
    Arena S., Hilal E.Y. (1976) Neurilemomas of the infratemporal space: report of a case and review of the literature. Arch Otolaryngol 102: 108–184Google Scholar
  61. 3.
    Asaari S. Tsuchida S., Fujiwara A., Yabuno N., Furuta T., Ohmoto T. (1992) Trigeminal neurinoma presenting with intratumoral hemorrhage: report of two cases. Clin Neurol Neurosurg 94: 219–224Google Scholar
  62. 4.
    Asari S., Katayama S., Itoh T., Tsuchida S., Ohmoto T. (1993) CT and MRI of haemorrhage into intracranial neuromas. Neuroradiology 35: 247–250PubMedGoogle Scholar
  63. 5.
    Camp R.C., Koestner A., Vinores S.A., Capen C.C. (1984) The effect of nerve growth factor and antibodies to nerve growth factor on ethylnitrosourea-induced neoplastic proliferation in rat trigeminal nerves. Vet Pathol 21: 67–73PubMedGoogle Scholar
  64. 6.
    Cantini R., Giorgetti W., Velleriani A.M., Burchianti M. (1987) Trigeminal schwannomas in adolescence. Pediatr Neurosci 13: 198–201PubMedGoogle Scholar
  65. 7.
    Chkili T., Medejel A., El Quarzazi A., Bellakhdar F. (1979) Neurinomas of the trigeminal nerve. Apropos of a case of ”hourglass” neurinoma occupying the posterior and middle fossa. Maroc Med 1: 223–228PubMedGoogle Scholar
  66. 8.
    Colin W. (1990) Trigeminal intraoral schwannomas. Compendium 11: 672, 674-677PubMedGoogle Scholar
  67. 9.
    Currie J., Lubin J.H., Lessell S. (1983) Chronic isolated abducens paresis from tumors at the base of the brain. Arch Neurol 40: 226–229PubMedGoogle Scholar
  68. 10.
    Del Priore L.V., Miller N.R. (1989) Trigeminal schwan noma as a cause of chronic, isolated sixth nerve palsy. Ophthalmologie 108: 726–729Google Scholar
  69. 11.
    Dolenc V.V. (1989) natomy and surgery of the cavernous sinus. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  70. 12.
    Dolenc V.V. (1994) Frontotemporal Epidural Approach to Trigeminal Neurinomas. Acta Neurochir (Wien) 130: 55–65Google Scholar
  71. 13.
    Embry B.M., Pritchard R. (1989) Trigeminal neurilemoma: appearance on magnetic resonance imaging. South Med J 82: 653–656PubMedGoogle Scholar
  72. 14.
    Findler G., Feinsod M., Sahar A. (1983) Trigeminal neurinoma with unusual presentation. Report of a case with trigeminal somatosensory-evoked response. Surg Neurol 19: 351–353PubMedGoogle Scholar
  73. 15.
    Fushimi S., Miura S., Suda Y., Fujii S., Kowada M. (1987) A case of trigeminal neurinoma with marked extracranial extension. No Shinkei Geka 15: 1117–1122PubMedGoogle Scholar
  74. 16.
    Genka S., Terao H., Matsutani M., Hori T., Ikeda A. (1981) A choice of two-stage operation and the microsurgical anatomy for large trigeminal neurinoma. No Shinkei Geka 9: 747–751PubMedGoogle Scholar
  75. 17.
    Hayashi K. (1983) Tissue culture of trigeminal nerves from rats administered transplacentally with ethylnitrosourea. Acta Med Okayama 37: 301–320PubMedGoogle Scholar
  76. 18.
    Hedeman L.S., Lewinsky B.S., Lochridge G.k, Trevor R. (1978) Primary malignant schwan noma of the Gasserian ganglion. Report of two cases. J Neurosurg 48: 279–283PubMedGoogle Scholar
  77. 19.
    Hitchon P., Graf C.J., McCabe B.F., Namba K. (1979) Trigeminal neurilemmoma presenting as a sphenoid sinus mass. Surg Neurol 11: 305–307PubMedGoogle Scholar
  78. 20.
    Ishiguro S., Kitabayashi M., Munemoto S., Ikeda M., Kimura A., Hayashi M. (1986) Neurinoma of the trigeminal root with recurrent intratumoral hemorrhage. Case report. Neurol Med Chir 26: 734–737Google Scholar
  79. 21.
    Katoh M., Kadoya S., Emori T., Kwak R. (1985) Trigeminal neurinoma presenting abducens nerve palsy as initial symptom: a report of two cases. No Shinkei Geka 13: 555–560PubMedGoogle Scholar
  80. 22.
    Lesoin F., Rousseaux M., Villette L., Autricque A., Dhellemmes P., Pellerin P., Vaneecloo J.M., Leys D., Jomin M. (1986) Neurinomas of the trigeminal nerve. Acta Neurochir (Wien) 82: 118–122Google Scholar
  81. 23.
    Levy W.J., Ansbacher L., Byer J., Nutkiewicz, Fratkin J. (1983) Primary malignant nerve sheath tumor of the Gasserian ganglion: a report of two cases. Neurosurgery 13: 572–576PubMedGoogle Scholar
  82. 24.
    Lunardi P., Missori P., Gagliardi F.M., Fraioli B. (1989) Trigeminal schwan noma with infratemporal extension. Case report. J Neurol Sci 33: 293–295Google Scholar
  83. 25.
    MCCormick P.C., Bello J.A., Post K.D. (1988) Trigeminal schwan noma. Surgical series of 14 cases with review of the literature. J Neurosurg 69: 850–860PubMedGoogle Scholar
  84. 26.
    Morniroli G. (1970) Das Trigeminusneurinom. Inaugural Dissertation. University of Zurich, Neurosurgical DepartmentGoogle Scholar
  85. 27.
    Nager G.T. (1984) Neurinomas of the trigeminal nerve. Am J Otolaryngol 5: 301–333PubMedGoogle Scholar
  86. 28.
    Pelissou I., Sindou M., Goutelle A., Pialat J., Duquesnel J. (1988) Neurinoma of the trigeminal nerve. Excision by combined suboccipital and pteriono-temporal approach. Neurochirurgie 34: 8–16PubMedGoogle Scholar
  87. 29.
    Pollack I.F., Sekhar L.N., Jannetta P.J., Janecka I.P. (1989) Neurilemomas of the trigeminal nerve. J Neurosurg 70: 737–745PubMedGoogle Scholar
  88. 30.
    Rigamonti D., Spetzler R.F., Shetter A., Drayer B.P. (1987) Magnetic resonance imaging and trigeminal schwan noma. Surg Neurol 28: 67–70PubMedGoogle Scholar
  89. 31.
    Ross D.L., Tew J.M. Jr., Benton C., Eisentrout C. (1984) Trigeminal schwan noma in a child. Neurosurgery 15: 108–110PubMedGoogle Scholar
  90. 32.
    Saito A., Nakazawa T., Matsuda M., Handa J. (1989) Comparison of computed tomographic scanning and magnetic resonance imaging in the diagnosis of trigeminal schwannoma. Report of four cases. Neurol Med Chir 29: 1101–1106Google Scholar
  91. 33.
    Shimabukuro H., Masuzawa T., Miyagi K., Sato F. (1983) Trigeminal neurinoma revealed by intratumoral hemorrhage following a minor head injury. Surg Neurol 19: 346–350PubMedGoogle Scholar
  92. 34.
    Tanaka A., Takaki T., Maruta Y. (1987) Neurinoma of the trigeminal root presenting as atypical trigeminal neuralgia: diagnostic values of orbicularis oculi reflex and magnetic resonance imaging. A case report. Neurosurgery 21: 733–736PubMedGoogle Scholar
  93. 35.
    Vaquero J., Cabezudo J.M., Lenuda G., Carrillo R., Bravo G. (1981) Sumultaneous posterior and middle cranial fossa neurinomas. Acta Neurochir (Wien) 55: 321–327Google Scholar
  94. 36.
    Wullenweber R., Traupe H., Schwarz G. (1976) Angiographic demonstration of a trigeminal neurinoma. Neuroradiology 10: 225–229PubMedGoogle Scholar
  95. 37.
    Yamada K., Ohta T., Miyamoto T. (1992) Bilateral trigeminal schwan noma associated with von Recklinghausen disease. AJNR Am J Neuroradiol 13: 299–300PubMedGoogle Scholar
  96. 38.
    Yamada H., Sakai N., Ando T., Nishimura Y., Kishimoto Y. (1980) Trigeminal neurinoma with massive extracranial extension: report of a case. No Shinkei Geka 8: 469–473PubMedGoogle Scholar
  97. 39.
    Yamashita J., Asato R., Handa H., Nakao S., Ogata M. (1977) Abducens nerve palsy as initial symptom of trigeminal schwan noma. J Neurol Neurosurg Psychiatry 40: 1190–1197PubMedGoogle Scholar
  98. 40.
    Yasui T., Hakuba A., Kim S.H., Nishimura S. (1989) Trigeminal neurinomas: operative approach in eight cases. J Neurosurg 71: 506–511PubMedGoogle Scholar
  99. 1.
    Adegbite A.B.O., Mcqueen J.D., Paine K.W.E., Rozdilsky B. (1985) Primary intracranial chondrosarcoma: a report of two cases. Neurosurgery 17: 490–494PubMedGoogle Scholar
  100. 2.
    Bottles K., Beckstead J.H. (1984) Enzyme histochemical characterization of chordomas. Am J Surg Pathol 8: 443–447PubMedGoogle Scholar
  101. 3.
    Bourgouin P.M., Tampieri D., Robitaille Y., Robert F., Bergeron D., del Carpio R., Melancon D., Either R. (1992) Low-grade myxoid chondrosarcoma of the base of the skull: CT, MR, and histopathology. J Comp Ass Tomograph 16: 268–273Google Scholar
  102. 4.
    Brooks J.J., LiVolsi V.A., Trojanowski J.Q. (1987) Does chondroid chordoma exist? Acta Neuropathologica 72: 229–235PubMedGoogle Scholar
  103. 5.
    Brown E., Hug E.B., Weber A.L. (1994) Chondrosarcoma of the skull base. Neuroimaging Cin North Am 4: 529–541Google Scholar
  104. 6.
    Coffin C.M., Swanson P.E., Wick M.R., Dehner L.P. (1993) Chordoma in childhood and adolescence. A clinicopathologic analysis of 12 cases. Arch Pathol Laboratory Med 117: 927–933Google Scholar
  105. 7.
    Coltrera M.D., Googe P.B., Harrist T.J., Hyams V.J, Schiller A.L., Goodman M.L. (1989) Chondrosarcoma of the temporal bone. Diagnosis and treatment of 13 cases and review of the literature. Cancer 58: 2689–2696Google Scholar
  106. 8.
    Fox J.E., Batsakis J.G., Owano L.R. (1968) Unusual manifestations of chordoma: report of two cases. J Bone Joint Surg 50A: 1618–1628Google Scholar
  107. 9.
    Heffelfinger M.J., Dahlin D.C., MacCarty C.S., Beabout J.W. (1973) Chordomas and cartilaginous tumors at the skull base. Cancer 32: 410–420PubMedGoogle Scholar
  108. 10.
    Ishida T., Dorfman H. (1994) Chondroid chordoma versus low-grade chondrosarcoma of the base of the skull: can immunohistochemistry resolve the controversy? J Neuro-Oncol 18: 199–206Google Scholar
  109. 11.
    Ishii R., Sato S., Ueki K., Oyake Y. (1974) Myxoosteochondroma in the pons. Journal of Neurosurgery 41: 240–243PubMedGoogle Scholar
  110. 12.
    Leedham P.W., Swash M. (1972) Chondrosarcoma with subarachnoid dissemination. J Pathol 107: 59–61PubMedGoogle Scholar
  111. 13.
    Meis J.M., Raymond A.K., Evans H.L., Charles R.E., Giraldo A.A. (1987) ”Dedifferentiated” chordoma. A clinicopathologic and immunohistochemical study of three cases. Am J Surg Pathol 11: 516–525PubMedGoogle Scholar
  112. 14.
    Morimoto T., Sasaki T., Tokakura K., Ishida T. (1992) Chondrosarcoma of the skull base. Report of six cases. Skull Base Surg 2: 177–185PubMedGoogle Scholar
  113. 15.
    Morris A.A., Rabinovitch R. (1947) Malignant chordoma of the lumbar region: report of a case with autopsy: comment on unusual metastasis of the brain, lungs, pancreas, sacrum and axillary and iliac lymph nodes. Arch Neurol Psychiatry 57: 547–564PubMedGoogle Scholar
  114. 16.
    O’Connell J.X., Renard L.G., Liebsch N.J., Erfird J.T., Munzenrider J.E., Rosenberg A.E. (1994) Base of skull chordoma. A correlative study of histologic and clinical features of 62 cases. Cancer 74: 2261–2267PubMedGoogle Scholar
  115. 17.
    Walker W.P., Landas S.K., Bromely C.M., Sturm M.T.M. (1991) Immunohistochemical distinction of classic and chondroid condromas. Modern Pathol 4: 661–666Google Scholar
  116. 18.
    Wang C.C., Everette J. Jr. (1968) Chordoma: brief review of the literature and report of a case with widespread metastasis.Cancer 22: 162–167PubMedGoogle Scholar
  117. 19.
    Watkins L., khudados E.S., Kaleoglu M., Revesz T., Sacares P., Crockard H.A. (1993) Skull base chordomas: a review of 38 patients, 1958-1988. Brit J Neurosurg 7: 241–248Google Scholar
  118. 20.
    Wu W.O., Lapi A. (1970) Primary non-skeletal intracranial cartilaginous neoplasms: report of a chondroma and mesenchymal chondrosarcoma. J Neurol Neurosurg Psychiatry 33: 469–470PubMedGoogle Scholar
  119. 1.
    Finkemeyer V.H., Kautzky R. (1968) Das Kavernom des sinus cavernosus. Zentabl Neurochir 29: 23–30Google Scholar
  120. 2.
    Harada T., Aoyama N., Terada H., Tsujimoto S., Hosogi Y., Iwasaki S. (1982) A case of extracerebral hemangioma of the middle fossa. Prog Comput Tomogr (Tokyo) 4: 460–465Google Scholar
  121. 3.
    Harper D.G., Buck D.R., Early D.O. (1982) Visual loss from cavernous hemangiomas of the middle cranial fossa. Arch Neurol 39: 252–254PubMedGoogle Scholar
  122. 4.
    Ichikizaki K., Shiobara R., Shizana H., Izaka Y., Toya S., Ohuchi T., Suzuki S., Shiga H., Ohtani M., Mikama K., Izumi G. (1980) The usefulness of computed tomography for the diagnosis of intracranial cavernous hemangiomas. Prog ComputTomogr (Tokyo) 2: 319–327Google Scholar
  123. 5.
    Ishijima Y., Matsumura H., Kageyma N. (1966) Intracranial cavernous hemangioma: Report of two cases. Arch Jpn Chir 35: 748–754Google Scholar
  124. 6.
    Ito J., Takahashi M., Saito A., Honda H., Yajima K., Ueki K. (1977) A case of cavernous hemangioma of the middle fossa with visualization of the feeding artery and faint tumor stain in cerebral angiography. Jpn J Clin Radiol 22: 339–344Google Scholar
  125. 7.
    Kawaguchi S., Ohsawa T. (1965) A case of cavernous hemangioma at the base of the skull. Clin Neurol (Tokyo) 5: 705–708Google Scholar
  126. 8.
    Kawai K., Fukui M., Tanaka A., Kuramoto S., Kitamura K. (1978) Extracerebral cavernous hemangioma of the middle fossa. Surg Neurol 8: 19–25Google Scholar
  127. 9.
    Kudo T., Ueki S., Kobayashi H., Torige H., Tadokoro M. (1989) Experience with the ultrasonic aspirator in a cavernous hemangioma of the cavernous sinus. Neurosurgery 23: 628–631Google Scholar
  128. 10.
    Meyer F.B., Lombardi D., Scheithauer B., Nichols D.A. (1990) Extra-axial cavernous hemangiomas involving the dural sinuses. J Neurosurg 73: 187–192PubMedGoogle Scholar
  129. 11.
    Namba S. (1983) Extracerebral cavernous hemangioma of the middle cranial fossa. Surg Neurol 19: 379–388PubMedGoogle Scholar
  130. 12.
    Odake G., Tanaka K. (1986) Cavernous hemangiomas of the middle fossa: case report and review of the literature. Neurol Med Chir (Tokyo) 26: 58–67Google Scholar
  131. 13.
    Ogasawara S., Nakazasa K., Katsura S., Oizumis (1973) Cavernoma on the intracranial base: report of a case. Brain Nerve (Tokyo) 6: 735–737Google Scholar
  132. 14.
    Rigamonti D., Pappas C.T.E., Spetzler R.F., Johnson P.C. (1990) Extracerebral cavernous angiomas of the middle fossa. Neurosurgery 27: 306–310PubMedGoogle Scholar
  133. 15.
    Rosenblum B., Rothman A.S., Ianzieri C., Song S. (1986) A cavernous sinus hemangioma. J Neurosurg 65: 716–718PubMedGoogle Scholar
  134. 16.
    Sepehrnia A., Tatagiba M., Brandis A., Samii M., Prawitz R.H. (1990) Cavernous angioma of the cavernous sinus: case report. Neurosurgery 27: 151–155PubMedGoogle Scholar
  135. 17.
    Tsuiki K., Abe S., Chiba M., Murakami H., Saiki I., Kanaya H. (1987) A case of cavernous angioma of the middle cranial fossa originating in the cavernous sinus with hyperprolactinemia. Neurol Surg (Tokyo) 15: 301–305Google Scholar
  136. 1.
    Baumann C.H.H., Bucy P.C. (1956) Paratrigeminal epidermoid tumors. J Neurosurg 13: 455–468PubMedGoogle Scholar
  137. 2.
    Hunt W.E., Meagher J.N., LeFever H.E., Yeman W. (1961) Painful ophthalmoplegia: its relation to indolent inflammation of the cavernous sinus. Neurology 11: 56–62PubMedGoogle Scholar
  138. 3.
    Tolosa E (1954) Periarteric lesions of the carotid siphon with the clinical features of a carotid infraclinoidal aneurysm. J Neurol Neurosurg Psychiatry 17: 300–302PubMedGoogle Scholar
  139. 1.
    Abrams L.S., Repka M.X. (1997) Visual outcome of craniopharyngioma in children. J Pediatr Ophthalmol Strabismus 34: 223–228PubMedGoogle Scholar
  140. 2.
    Amacher A.L. (1980) Craniopharyngioma: the controversy regarding radiotherapy. Childs Brain 6: 57–64PubMedGoogle Scholar
  141. 3.
    Baskin D.S., Wilson C.B. (1986) Surgical management of craniopharyngiomas. A review of 74 cases. J Neurosurg 65: 22–27PubMedGoogle Scholar
  142. 4.
    Bhagwati S.N., Deopujari C.E., Parulekar G.D. (1990) Lamina terminalis approach for retrochiasmal craniopharyngiomas. Childs Nerv Syst 6: 425–429PubMedGoogle Scholar
  143. 5.
    Bucci M.N., Chin L.S., Hoff J.T. (1987) Preoperative morbidity associated with operative resection of craniopharyngioma: a review of ten years experience. Neurochirurgia 30: 135–138PubMedGoogle Scholar
  144. 6.
    Cabezudo Artero J.M., Vaquero Crespo J., Bravo Zabalgoitia G. (1987) Status of vision following surgical treatment of craniopharyngiomas. Acta Neurochir (Wien) 73: 165–177Google Scholar
  145. 7.
    Cabezudo J.M., Vaquero J., Areitio E., et al (1981) Craniopharyngiomas: a critical approach to treatment. J Neurosurg 55: 371–375PubMedGoogle Scholar
  146. 8.
    Caldarelli M., di Rocco C., Papacci F., et al (1998) Management of recurrent craniopharyngioma. Acta Neurochir (Wien) 140: 447–454Google Scholar
  147. 9.
    Carmel P.W. (1985) Vegetative dysfunctions of the hypothalamus. Acta Neurochir (Wien) 75: 113–121Google Scholar
  148. 10.
    Carmel P.W., Antunes J.L., Chang C.H. (1982) Craniopharyngiomas in children. Neurosurgery 11: 382–389PubMedGoogle Scholar
  149. 11.
    Chung W.Y., Pan D.H., Shiau C.Y., et al (2000) Gamma knife radiosurgery for craniopharyngiomas. J Neurosurg 93 (Suppl3): 47–56Google Scholar
  150. 12.
    Curtis J., Daneman D., Hoffman H.J., et al (1994) The endocrine outcome after surgical removal of craniopharyngiomas. Pediatr Neurosurg 21 [Suppl]1: 24–27Google Scholar
  151. 13.
    DeVile C.J., Grant D.B., Hayward R.D., et al (1996) Growth and endocrine sequelae of craniopharyngioma. Arch Dis Child 75: 108–114PubMedGoogle Scholar
  152. 14.
    DeVile C.J., Grant D.B., Kendall B.E., et al (1996) Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted? J Neurosurg 85: 73–81Google Scholar
  153. 15.
    Fahlbusch R., Hongger J., Paulus W., et al (1999) Surgical treatment of craniopharyngiomas: experience with 168 patients. J Neurosurg 90: 237–250PubMedGoogle Scholar
  154. 16.
    Fisher E.G., Welch K., Shillito J. Jr., et al (1990) Craniopharyngiomas in children. Long-term effects of conservative surgical procedures combined with radiation therapy. J Neurosurg 73: 534–540Google Scholar
  155. 17.
    Garcia-Uria J. (1978) Surgical experience with craniopharyngioma in adults. Surg Neurol 9: 11–14PubMedGoogle Scholar
  156. 18.
    Graham P.H., Gattamaneni H.R., Birch J.M. (1992) Pediatric craniopharyngiomas: a regional review. Br J Neurosurg 6: 187–193PubMedGoogle Scholar
  157. 19.
    Habrand J.L., Ganry O., Couanet D., et al (1999) The role of rad iation therapy in the management of craniopharyngioma: a 25-year experience and review of the literature. Int J Radiat Oncol Biol Phys 44: 255–263PubMedGoogle Scholar
  158. 20.
    Hayward R. (1999) The present and future management of childhood craniopharyngioma. Childs Nerv Syst 15: 764–769PubMedGoogle Scholar
  159. 21.
    Hoff J.T., Patterson R.H. Jr. (1972) Craniopharyngiomas in children and adults. J Neurosurg 36: 299–302PubMedGoogle Scholar
  160. 22.
    Hoffman H.J., De Silva M., Humphreys R.P., et al (1992) Aggressive surgical management of craniopharyngiomas in children. J Neurosurg 76: 47–52PubMedGoogle Scholar
  161. 23.
    Honegger J., Buchfelder M., Fahlbusch R. (1999) Surgical treatment of craniopharyngiomas: endocrinological results. J Neurosurg 90: 251–257PubMedGoogle Scholar
  162. 24.
    Katz E.L. (1975) Late results of radical excision of craniopharyngiomas in children. J Neurosurg 42: 86–93PubMedGoogle Scholar
  163. 25.
    King T.T. (1979) Removal of intraventricular craniopharyngiomas through the lamina terminalis. Acta Neurochir 45: 277–286Google Scholar
  164. 26.
    Klein H.J., Rath S.A. (1989) Removal of tumors in the III ventricle using the lamina terminalis approach. Three cases of isolated growth of craniopharyngiomas in the III ventricle. Childs Nerv Syst 5: 144–147PubMedGoogle Scholar
  165. 27.
    Maira G., Anile C., Colosimo C., et al (2000) Craniopharyngiomas of the third ventricle: trans-lamina terminal is approach. Neurosurgery 47: 857–865PubMedGoogle Scholar
  166. 28.
    Mokry M. (1999) Craniopharyngiomas: a six year experience with Gamma Knife radiosurgery. Stereotact Funct Neurosurg 72 [Suppl] 1: 140–149Google Scholar
  167. 29.
    Mutlukan E., Cullen J.F. (1990) Visual outcome after craniopharyngioma. Ophthalmology 97: 539–540PubMedGoogle Scholar
  168. 30.
    Patterson R.H. Jr., Danylevich A. (1980) Surgical removal of craniopharyngiomas by a transcranial approach through the lamina terminalis and sphenoid sinus. Neurosurgery 7: 111–117PubMedGoogle Scholar
  169. 31.
    Repka M.X., Miller N.R., Miller M. (1989) Visual outcome after surgical removal of craniopharyngiomas. Ophthalmology 96: 195–199PubMedGoogle Scholar
  170. 32.
    Richmond I.L., Wara W.M., Wilson C.B. (1980) Role of radiation therapy in the management of craniopharyngiomas in children. Neurosurgery 6: 513–517PubMedGoogle Scholar
  171. 33.
    Sklar C.A. (1994): Craniopharyngioma: encodrine sequellae of treatment. Pediatr Neurosurg 21 [Suppl] 1: 120–123Google Scholar
  172. 34.
    Sorva R., Heiskanen O., Perheentupa J. (1988) Craniopharyngioma surgery in children: endocrine and visual outcome. Childs Nerv Syst 4: 97–99PubMedGoogle Scholar
  173. 35.
    Thomsett M.J., Conte F.A., Kaplan S.L., et al (1980) Endocrine and neurologic outcome in childhood craniopharyngioma: review of effect of treatment in 42 patients. J Pediatr 97: 728–735PubMedGoogle Scholar
  174. 36.
    Weiss M., Sutton L., Marcial V., et al (1989) The role of radiation therapy in the management of childhood craniopharyngioma. Int J Radiant Oncol Biol Phys 17: 1313–1321Google Scholar
  175. 37.
    Wen D.Y., Seljeskog E.L., Haines S.J. (1992) Microsurgical management of craniopharyngiomas. Br J Neurosurg 6: 467–474PubMedGoogle Scholar
  176. 38.
    Yaşargil M.G., Curcic M., Kis M., et al (1990) Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg 73: 3–11PubMedGoogle Scholar
  177. 39.
    Zuccaro G., Jamovich R., Mantese B., et al (1996) Complications in paediatric craniopharyngioma treatment. Child Nerv Syst 12: 385–391Google Scholar
  178. 1.
    Greenberg H.S., Deck M.D., Vikram B., Chu F.C.H., Posner J.B. (1981) Metastasis to the base of the skull: clinical findings in 43 patients. Neurology 31: 530–537PubMedGoogle Scholar
  179. 2.
    Jääiaskeläinen J., Servo A., Haltia M., Wahlström T., Valtonen S. (1985a) Intracranial hemangiopericytoma: radiology, surgery, radiotherapy, and outcome in 21 patients. Surg Neurol 23: 227–236Google Scholar
  180. 3.
    Lam S., Margo C.E., Beck R., Pusateri T.J., Pasucci S. (1987) Cavernous sinus syndrome as the initial manifestation of multiple myeloma. J Clin Neuroophthalmol 7: 135–138PubMedGoogle Scholar
  181. 4.
    Nakatomi H., Sasaki T., Kawamoto S., Fujimaki T., Furuya K., Kirino T. (1996) Primary cavernous sinus malignant lymphoma treated by gamma knife radiosurgery: case report and review of the literature. Surg Neurol 46: 272–279PubMedGoogle Scholar
  182. 5.
    Nogami K., Nishijima M., Endoh S., Takaku A. (1992) Malignant melanoma metastatic to cavernous sinus and skull with an unknown primary origin: report of a case. Neurol Surg 20: 1017–1020Google Scholar
  183. 6.
    Post M.J.D., Mendez D.R., Kline L.B., Acker J.D., Glaser J.S. (1985) Metastatic disease to the cavernous sinus: clinical syndrome and CT diagnosis. J Comput Assist Tomogr 9: 115–120PubMedGoogle Scholar
  184. 7.
    Reynard M., Brinkley J.R. (1983) Cavernous sinus syndrome caused by rhabdomyosarcoma. Ann Ophthalmol 15: 94–97PubMedGoogle Scholar
  185. 8.
    Sham J.S.T., Cheung Y.K., Choy D., Chan F.L., Leong L. (1991) Nasopharyngeal carcinoma: CT evaluation of patterns of tumor spread. AJNR Am J Neuroradiol 12: 265–270PubMedGoogle Scholar
  186. 9.
    Thomas H.G., Dolman C.L., Berry K. (1981) Malignant meningioma: clinical and pathological features. J Neurosurg 55: 929–934PubMedGoogle Scholar
  187. 10.
    Traserra J., Comas J., Conde C., Cuchi A., Cardesa A. (1990) Metastatic involvement of the cavernous sinus from primary pharyngolaryngeal tumors. Head Neck 12: 426–429PubMedGoogle Scholar

Copyright information

© Springer-Verlag Wien 2003

Authors and Affiliations

  • Vinko V. Dolenc
    • 1
  1. 1.Department of NeurosurgeryUniversity Medical Centre LjubljanaSlovenia

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