Introduction and Historical Landmarks
The selective uptake of a photosensitizer into neoplastic tissue and its selective destruction by subsequent irradiation (principle of photodynamic therapy (PDT)) is a fascinating but not a new idea. The ability of several dyes (e.g., acridine) to sensitize microorganisms (e.g., paramecium) for their destruction by a following exposure to light was first mentioned in 1900 (Raab, 1900). At that time, the author and his co-workers also recognized that the described reaction depended on oxygen and therefore they called it “photodynamic action” or “photodynamic effect” (Fig. 1) (von Tappeiner, 1904).
KeywordsPhotodynamic Action Pityriasis Versicolor Porfimer Sodium Skin Photosensitivity Singlet Oxygen Quantum Yield
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