Introduction and Historical Landmarks

  • Clemens Fritsch
  • Thomas Ruzicka


The selective uptake of a photosensitizer into neoplastic tissue and its selective destruction by subsequent irradiation (principle of photodynamic therapy (PDT)) is a fascinating but not a new idea. The ability of several dyes (e.g., acridine) to sensitize microorganisms (e.g., paramecium) for their destruction by a following exposure to light was first mentioned in 1900 (Raab, 1900). At that time, the author and his co-workers also recognized that the described reaction depended on oxygen and therefore they called it “photodynamic action” or “photodynamic effect” (Fig. 1) (von Tappeiner, 1904).


Photodynamic Action Pityriasis Versicolor Porfimer Sodium Skin Photosensitivity Singlet Oxygen Quantum Yield 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag/Wien 2003

Authors and Affiliations

  • Clemens Fritsch
    • 1
  • Thomas Ruzicka
    • 2
  1. 1.Privatpraxis für Dermatologie, Allergologie and VenerologieDüsseldorfGermany
  2. 2.HautklinikUniversität DüsseldorfGermany

Personalised recommendations