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Representation of Odor Information in the Olfactory System: From Biology to an Artificial Nose

  • John S. Kauer
  • Joel White

Abstract

The olfactory systems of animals as diverse as insects and primates are well-known for having extraordinary sensitivity while, at the same time, exhibiting broad discriminative abilities. These properties, often mutually exclusive in other chemical recognition systems, appear to arise from the parallel, distributed nature of the processes that underlie how odors are encoded at each level in the olfactory pathway in the brain. In this paper we describe how we have tried to characterize the physiological aspects of these processes in biological experiments, capture these processes in a computational model, and then to use these observations to design and build a biologically inspired artificial device. The Tufts Medical School Nose has achieved a degree of sensitivity and discriminability that, for certain compounds under defined conditions, approaches that of its biological parent.

Keywords

Olfactory Bulb Olfactory Epithelium Olfactory System Olfactory Function Olfactory Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ache B (1994) Towards a common strategy for transducing olfactory information. Semin Cell Biol 5: 55–63PubMedCrossRefGoogle Scholar
  2. Anholt RR (1993) Molecular neurobiology of olfaction. Critical Reviews. Neurobiology 7: 1–22CrossRefGoogle Scholar
  3. Barnard SM, Walt DR (1991) A fibre-optic chemical sensor with discrete sensing sites. Nature 353: 338–340CrossRefGoogle Scholar
  4. Buck LB (1996) Information coding in the mammalian olfactory system. Cold Spring Harbor Symp Quant Biol 61: 147–155PubMedCrossRefGoogle Scholar
  5. Christensen TA, White J (2000) Representation of olfactory information in the brain. In: Finger TE, Silver WL, Restrepo D (eds) The Neurobiology of Taste and Smell. Wiley, New York, pp 197–228 Cinelli AR, Hamilton KA, KauerGoogle Scholar
  6. JS (1995) Salamander olfactory bulb neuronal activity observed by video-rate voltage-sensitive dye imaging. III. Spatio-temporal properties of responses evoked by odorant stimulation. J Neurophysiol 73: 2053–2071Google Scholar
  7. Cinelli AR, Kauer JS (1995) Salamander olfactory bulb neuronal activity observed by video-rate voltage-sensitive dye imaging. II. Spatiotemporal properties of responses evoked by electrical stimulation. J Neurophysiol 73: 2033–2052PubMedGoogle Scholar
  8. Friedrich RW, Korsching SI (1998) Chemotopic, combinatorial, and noncombinatorial odorant representations in the olfactory bulb revealed using a voltage-sensitive transducer. J Neurosci 18: 9977–9988PubMedGoogle Scholar
  9. George V, Jenkins T, Leggett D, Cragin J, Phelan J, Oxley J, Pennington J (1999) Progress on determining the vapor signature of a buried landmine. Proc 13th Ann Int Symp Aerospace/ Defense Sensing, Sim Controls 258–269Google Scholar
  10. Graziadei PPC (1973) Cell dynamics in the olfactory mucosa. Tissue & Cell 5: 113–131Google Scholar
  11. Haberly LB (2001) Parallel-distributed processing in olfactory cortex: new insights from morphological and physiological analysis of neuronal circuitry. Chem Senses 26: 551–576PubMedCrossRefGoogle Scholar
  12. Ham CL, Jurs PC (1985) Structure-activity studies of musk odorants using pattern recognition: monocyclic nitrobenzenes. Chem Senses 10: 491–506CrossRefGoogle Scholar
  13. Hartell M, Myers L, Waggoner L, Hallowell S, Petrousky J (1998) Design and testing of a quantitative vapor delivery system. Proc 5th Int Symp on Anal Det ExplosivesGoogle Scholar
  14. Hildebrand JG, Shepherd GM (1997) Mechanisms of olfactory discrimination: converging evidence for common principles across phyla. Ann Rev Neurosci 20: 595–631PubMedCrossRefGoogle Scholar
  15. Hudson R (1999) From molecule to mind: the role of experience in shaping olfactory function. J Comp Physiol A 185: 297–304PubMedCrossRefGoogle Scholar
  16. Hudson R, Distel H (1987) Regional autonomy in the peripheral processing of odor signals in newborn rabbits. Brain Res 421: 85–94PubMedCrossRefGoogle Scholar
  17. Kauer JS (1973) Response properties of single olfactory bulb neurons using odor stimulation of small nasal areas in the salamander. University of Pennsylvania 142pGoogle Scholar
  18. Kauer JS (1980) Some spatial characteristics of central information processing in the vertebrate olfactory pathway. In: van der Starre H (ed) Olfaction and Taste VII. pp 227–236Google Scholar
  19. Kauer JS (1987) Coding in the olfactory system. In: Finger TE, Silver WL (eds) Neurobiology of Taste and Smell. Wiley, New York, pp 205–231Google Scholar
  20. Kauer JS (1991) Contributions of topography and parallel processing to odor coding in the vertebrate olfactory pathway. TINS 14: 79–85PubMedGoogle Scholar
  21. Kauer JS, Cinelli AR (1993) Are there structural and functional modules in the vertebrate olfactory bulb? Micr Res and Tech 24: 157–167CrossRefGoogle Scholar
  22. Kauer JS, Moulton DG (1974) Responses of olfactory bulb neurones to odour stimulation of small nasal areas in the salamander. J Physiol (Lond.) 243: 717–737Google Scholar
  23. Kauer JS, White J (2001) Imaging and coding in the olfactory system. Ann Rev Neurosci 24: 963–979PubMedCrossRefGoogle Scholar
  24. Mombaerts P (1999) Molecular biology of odorant receptors in vertebrates. Ann Rev Neurosci 22: 487–509PubMedCrossRefGoogle Scholar
  25. Mori K, Nagao H, Yoshihara Y (1999) The olfactory bulb: coding and processing of odor molecule information. Science 286: 711–715PubMedCrossRefGoogle Scholar
  26. Persaud K, Dodd G (1982) Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose. Nature 299: 352–355PubMedCrossRefGoogle Scholar
  27. Ressler KJ, Sullivan SL, Buck LB (1993) A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell 73: 597–609PubMedCrossRefGoogle Scholar
  28. Rubin BD, Katz LC (1999) Optical imaging of odorant representations in the mammalian olfactory bulb. Neuron 23: 499–511PubMedCrossRefGoogle Scholar
  29. Schild D, Restrepo D (1998) Transduction mechanisms in vertebrate olfactory receptor cells. Physiol Rev 78: 429–466PubMedGoogle Scholar
  30. Shepherd GM (1987) A molecular vocabulary for olfaction. Ann NY Acad Sci 510: 98–103PubMedCrossRefGoogle Scholar
  31. Shepherd GM (1994) Discrimination of molecular signals by the olfactory receptor neuron. Neuron 13: 771–790PubMedCrossRefGoogle Scholar
  32. Simmons PA, Getchell TV (1981) Neurogenesis in olfactory epithelium: loss and recovery of trans-epithelial voltage transients following olfactory nerve section. J Neurophysiol 45: 516–528PubMedGoogle Scholar
  33. Slotnick BM, Bell GA, Panhuber H, Laing DG (1997) Detection and discrimination of propionic acid after removal of its 2-DG identified major focus in the olfactory bulb: a psychophysical analysis. Brain Res 762: 89–96PubMedCrossRefGoogle Scholar
  34. Uchida N, Takahashi YK, Tanifuji M, Mori K (2000) Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features. Nature Neurosci 3: 1035–1043PubMedCrossRefGoogle Scholar
  35. Vassar R, Chao KC, Sitcheran R, Nunez JM, Vosshall LB, Axel R (1994) Topographic organization of sensory projections to the olfactory bulb. Cell 79: 981–991PubMedCrossRefGoogle Scholar
  36. White J, Hamilton KA, Neff SR, Kauer JS (1992) Emergent properties of odor information coding in a representational model of the salamander olfactory bulb. J Neurosci 12: 1772–1780PubMedGoogle Scholar
  37. White J, Kauer JS, Dickinson TA, Walt DR (1996) Rapid analyte recognition in a device based on optical sensors and the olfactory system. Anal Chem 68: 2191–2202PubMedCrossRefGoogle Scholar
  38. Wilson DA (1998) Habituation of odor responses in the rat anterior piriform cortex. J Neurophysiol 79: 1425–1440PubMedGoogle Scholar
  39. Wilson DA (2000) Odor specificity of habituation in the rat anterior piriform cortex. J Neurophysiol 83: 139–145PubMedGoogle Scholar
  40. Yang J-S, Swager TM (1998) Fluorescent porous polymer films as TNT chemosensors: electronic and structural effects. J Am Chem Soc 120: 11864–11873CrossRefGoogle Scholar
  41. Young TA, Wilson DA (1999) Frequency-dependent modulation of inhibition in the rat olfactory bulb. Neurosci Lett 276: 65–67PubMedCrossRefGoogle Scholar
  42. Zou Z, Horowitz LF, Montmayeur J-P, Snapper S, Buck LB (2001) Genetic tracing reveals a steroeotyped sensory map in the olfactory cortex. Nature 414: 173–179PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2003

Authors and Affiliations

  • John S. Kauer
  • Joel White

There are no affiliations available

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