Mechanism of Shear Stress-Induced Coronary Microvascular Dilation
In the coronary circulation, fluid shear stress acts as an important, moment-to-moment regulator of vascular resistance. Coronary microvessels display profound vasodilation to increased shear stress, a response shown to be mediated by endothelium-dependent release of nitric oxide. However, the sensory transduction mechanism and the intracellular signaling pathway by which shear stress stimulates release of nitric oxide in endothelial cells is not completely understood. In this chapter, the involvement of cytoskeleton, integrin/focal adhesion proteins, protein kinases, membrane potassium channels and calcium mobilization in endothelial activation and vasodilation to elevated shear stress is discussed. The vasomotor regulation by shear stress in the coronary microcirculation is specially emphasized.
KeywordsNitric Oxide Fluid Shear Stress Bovine Aortic Endothelial Cell Coronary Microcirculation Myogenic Response
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