On the extrapolation from animal models to human disease for the design of immunotherapy in autoimmune diabetes

  • Jean-François Bach


Type 1 diabetes, insulin-dependent diabetes mellitus (IDDM) is a T-cell-mediated autoimmune disease (Bach 1994). It is thus logical to attempt to stop or better prevent disease progression by immunotherapy. A multitude of immunological treatments have been shown to be successful in the most currently available model of type 1 diabetes, namely, the nonobese diabetic (NOD) mouse. This observation may be taken in a positive fashion, paving the way for testing these strategies in humans. Conversely, one may wonder whether the NOD mouse is not, in some ways, “too sensitive” to immunological intervention, rendering the extrapolation of results obtained in NOD mice to human diabetes uncertain. This is, in fact, a very complex question which shall be addressed in some detail below.


Glutamic Acid Decarboxylase Nonobese Diabetic Mouse Antilymphocyte Serum Positive Fashion Kampo Formulation 
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© Springer-Verlag Wien 2003

Authors and Affiliations

  • Jean-François Bach
    • 1
    • 2
  1. 1.Maladies Auto-immunesUnité de Institut National de la Santé et de la Recherche Médicale,Hôpital NeckerParisFrance
  2. 2.INSERM U25, Hôpital NeckerParis Cedex 15France

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