Experimental Production of Brain Tumours Experimental Induction and Transplantation of Brain Tumors in Animals
Gliomas may be induced in some strains of mice by intracerebral implantation of small pellets of carcinogens such as methylcholanthrene or benzpyrene. A latent period of 4 months to 2 years may elapse before the tumors are clinically evident. This length of exposure of the brain is relatively long in the life span of the mouse (usually a little more than 2 years). Neoplasms occuring earlier than 4 months after implantation are often sarcomas. The presence of an experimentally induced glioma in the mouse is easily recognized by paralytic or ataxic motor signs. The brain tumor may then be harvested and grown in successive transplants in the subcutaneous tissue, brain, or eye of homologous animals. Transplants are generally less successful in heterologous animals, in tissue culture or in the allantoic membrane of the chick egg.
KeywordsBrain Tumor Glial Cell Glioblastoma Multiforme Experimental Induction Individual Resistance
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- Cohn, A., and H. M. Zimmerman, Growth behavior of chemically induced mouse brain tumors in the chick embryo. Excerpta med., sec. 8, 8 (1955), 818 (abstract).Google Scholar
- Ewing, J., Neoplastic diseases. Saunders, Philadelphia, 1940.Google Scholar
- Koenig, H., M. Bunge and R. Bunge, Personal communication. 1961.Google Scholar
- Netsky, M. G., J. Shapiro, M. Hoffman, B. Corsentino, J. R. Freid and H. M. Zimmerman, The effects of single doses of roentgen radiation on experimentally induced gliomas: with a critical review of the effects of roentgen radiation on gliomas in man. Amer. J. Roentgenol. 76 (1956), 351–366.PubMedGoogle Scholar
- Willis, R. A., Pathology of tumors. Mosby, St. Louis, 1948.Google Scholar
- Zimmerman, H. M., and H. Arnold, Chemical carcinogens and animal species as factors in experimental brain tumors. J. Neuropath., Baltimore, 2 (1943), 416 to 417.Google Scholar
- Zimmerman, H. M., and H. Arnold, Experimental brain tumors. IV. The incidence in different strains of mice. Cancer Res. 4 (1944), 98–101.Google Scholar
- Zimmerman, H. M., and N. Maier, Experimental brain tumors. Proc. N. Y. Path. Soc. (1948/49), 40–42.Google Scholar
- Ziilch, K. J., Brain tumors: their biology and pathology. Springer, New York, 1957.Google Scholar