Experimental Production of Brain Tumours Experimental Induction and Transplantation of Brain Tumors in Animals

  • M. G. Netsky
Conference paper
Part of the Acta Neurochirurgica / Supplementum book series (NEUROCHIRURGICA, volume 10)


Gliomas may be induced in some strains of mice by intracerebral implantation of small pellets of carcinogens such as methylcholanthrene or benzpyrene. A latent period of 4 months to 2 years may elapse before the tumors are clinically evident. This length of exposure of the brain is relatively long in the life span of the mouse (usually a little more than 2 years). Neoplasms occuring earlier than 4 months after implantation are often sarcomas. The presence of an experimentally induced glioma in the mouse is easily recognized by paralytic or ataxic motor signs. The brain tumor may then be harvested and grown in successive transplants in the subcutaneous tissue, brain, or eye of homologous animals. Transplants are generally less successful in heterologous animals, in tissue culture or in the allantoic membrane of the chick egg.


Brain Tumor Glial Cell Glioblastoma Multiforme Experimental Induction Individual Resistance 
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© Springer-Verlag/Wien 1964

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  • M. G. Netsky

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