• L. J. Rubinstein
Conference paper
Part of the Acta Neurochirurgica / Supplementum book series (NEUROCHIRURGICA, volume 10)


In 1948, Dorothy Russell, Marshall and Smith 10 reported under the title of “Microgliomatosis, a form of reticulosis affecting the brain”, seven cases with a focal tumor-like proliferation of cells of predominantly microglial type. In four cases, the process was confined to the brain. In three, similar proliferations were present in other organs, including the cervical glands, spleen, kidney, parotid, bone-marrow and lungs. In the brain, the macroscopically visible infiltrates were either single or multiple, involving the cerebrum, basal ganglia, brain stem or cerebellum. The microscopic characteristics of the cerebral lesions consisted in: 1. The presence of extensive microscopic foci of cellular proliferation beyond the macroscopically defined borders of the main tumor masses. 2. An extensive infiltration, by tumor cells, of the Virchow-Robin spaces, with well-marked lymphocytic cuffings further afield, mimicking an encephalitis. 3. The cytological similarity of many of these cells to adult microglia of the brain or to histiocytes elsewhere in the body, with the presence of more primitive elements of the reticuloendothelial system, regarded as reticulum cells. 4. A positive impregnation of the more differentiated cell elements by silver techniques specific for the mature macrophage system (Weil-Davenport, or Penfield’s modification of Hortega’s silver carbonate method for microglia), with a more feeble impregnation of the less differentiated elements.


Reticuloendothelial System Reticulum Cell Silver Impregnation Perivascular Cuff Reticulum Cell Sarcoma 
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© Springer-Verlag/Wien 1964

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  • L. J. Rubinstein

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